GR1006941B - Πεπτιδικη συνθεση (peptide synthesis) - Google Patents

Πεπτιδικη συνθεση (peptide synthesis)

Info

Publication number
GR1006941B
GR1006941B GR20090100310A GR20090100310A GR1006941B GR 1006941 B GR1006941 B GR 1006941B GR 20090100310 A GR20090100310 A GR 20090100310A GR 20090100310 A GR20090100310 A GR 20090100310A GR 1006941 B GR1006941 B GR 1006941B
Authority
GR
Greece
Prior art keywords
chain
cysteine residues
relaxin
peptide synthesis
peptide
Prior art date
Application number
GR20090100310A
Other languages
English (en)
Inventor
Κλεομενης Μπαρλος
Δημητριος Γατος
Κωνσταντινος Μπαρλος
Original Assignee
Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), filed Critical Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),
Priority to GR20090100310A priority Critical patent/GR1006941B/el
Priority to EP10732429.5A priority patent/EP2437776B1/en
Priority to PCT/IB2010/001477 priority patent/WO2010140060A2/en
Priority to CN201080034142XA priority patent/CN102647996A/zh
Priority to DK10732429.5T priority patent/DK2437776T3/en
Priority to ES10732429.5T priority patent/ES2616871T3/es
Priority to US12/783,223 priority patent/US8785384B2/en
Publication of GR1006941B publication Critical patent/GR1006941B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Μία μέθοδος για την παραγωγή ινσουλινοειδών πεπτιδίων, παραδείγματος χάριν μία ρηλαξίνη, που περιλαμβάνει οξείδωση μίας μεθειονίνης της Β αλυσίδας που περιέχει κατάλοιπα κυστεΐνης και συνδυασμένες την Β αλυσίδα με την Α και διαθέτει κυστεϊνες για να σχηματίσει ένα πεπτίδιο που περιέχει διαμοριακούς δισουλφιδικούς δεσμούς και βιολογική δραστικότητα. Αποκαλύπτονται επίσης η συνθετική ρηλαξίνη 1 και στην μεθειονίνη οξειδωμένες ρηλαξίνες και Met(O) Β αλυσίδες που εμφανίζουν μεγαλύτερη διαλυτότητα.
GR20090100310A 2009-06-01 2009-06-01 Πεπτιδικη συνθεση (peptide synthesis) GR1006941B (el)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GR20090100310A GR1006941B (el) 2009-06-01 2009-06-01 Πεπτιδικη συνθεση (peptide synthesis)
EP10732429.5A EP2437776B1 (en) 2009-06-01 2010-05-19 Relaxin peptide synthesis
PCT/IB2010/001477 WO2010140060A2 (en) 2009-06-01 2010-05-19 Peptide synthesis
CN201080034142XA CN102647996A (zh) 2009-06-01 2010-05-19 松弛素肽合成
DK10732429.5T DK2437776T3 (en) 2009-06-01 2010-05-19 Relaxin peptide synthesis
ES10732429.5T ES2616871T3 (es) 2009-06-01 2010-05-19 Síntesis de péptido relaxina
US12/783,223 US8785384B2 (en) 2009-06-01 2010-05-19 Peptide synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20090100310A GR1006941B (el) 2009-06-01 2009-06-01 Πεπτιδικη συνθεση (peptide synthesis)

Publications (1)

Publication Number Publication Date
GR1006941B true GR1006941B (el) 2010-08-27

Family

ID=42732157

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20090100310A GR1006941B (el) 2009-06-01 2009-06-01 Πεπτιδικη συνθεση (peptide synthesis)

Country Status (7)

Country Link
US (1) US8785384B2 (el)
EP (1) EP2437776B1 (el)
CN (1) CN102647996A (el)
DK (1) DK2437776T3 (el)
ES (1) ES2616871T3 (el)
GR (1) GR1006941B (el)
WO (1) WO2010140060A2 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1007010B (el) * 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
GB201110833D0 (en) 2011-06-24 2011-08-10 Bold Venture Llc Compositions
CN103764674A (zh) * 2011-08-04 2014-04-30 法瑞斯生物技术有限公司 制备人松弛素-2的方法
EP2630964A1 (en) * 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
CN104892748B (zh) * 2014-03-04 2018-12-21 深圳翰宇药业股份有限公司 人类松弛素-2衍生物以及由其制备人类松弛素-2的方法
CN104922661B (zh) * 2014-03-20 2018-08-24 深圳翰宇药业股份有限公司 一种含有serelaxin的药物组合物及其制备方法
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
CA3004530A1 (en) 2015-11-07 2017-05-11 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
BR112019004314A2 (pt) * 2016-09-06 2019-05-28 Chemical & Biopharmaceutical Laboratories Of Patras S A derivados pró-insulina
EP3551226A1 (en) 2016-12-12 2019-10-16 MultiVir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
KR20200135986A (ko) 2018-03-19 2020-12-04 멀티비르 인코포레이티드 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053488A (en) * 1982-08-12 1991-10-01 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a gene sequence coding for human relaxin
US5023321A (en) 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
NZ206534A (en) 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
CA2051375C (en) 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
DE69432704T2 (de) * 1993-06-21 2004-02-26 Genentech, Inc., South San Francisco Verfahren zur Herstellung von humanen Relaxin
US20050032683A1 (en) * 2000-10-04 2005-02-10 Amento Edward P. Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US7893197B2 (en) * 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
GR1006759B (el) * 2008-12-22 2010-04-20 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras) Εξελιγμενη χημικη μεθοδος συνθεσης της ανθρωπινης ρηλαξινης

Also Published As

Publication number Publication date
DK2437776T3 (en) 2017-03-06
CN102647996A (zh) 2012-08-22
WO2010140060A3 (en) 2011-05-19
US20110039778A1 (en) 2011-02-17
EP2437776B1 (en) 2016-12-07
EP2437776A2 (en) 2012-04-11
US8785384B2 (en) 2014-07-22
ES2616871T3 (es) 2017-06-14
WO2010140060A2 (en) 2010-12-09

Similar Documents

Publication Publication Date Title
GR1006941B (el) Πεπτιδικη συνθεση (peptide synthesis)
BRPI0413276B8 (pt) derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
EP1888728A4 (en) Fatty acid analogues, D.H. DHA DERIVATIVES FOR USE AS A MEDICAMENT
GEP20135944B (en) Glucagon/glp-1 receptor co-agonists
TW200740453A (en) I-type collagen production promoting composition
CY1116917T1 (el) Αναλογα οξυντομοντουλινης
WO2011064782A3 (en) Multi-component stent-graft system for implantation in a blood vessel with multiple branches
DOP2006000048A (es) Production of ferronickel (producción de ferroniquel)
CL2012000184A1 (es) Metodo para reducir la produccion gastrointestinal de metano en un rumiante, que comprende administrar una combiancion de un compuesto nitrato y un de sulfato; uso de una composicion que comprende un compuesto nitrato y uno sulfato; alimento compuesto para animales; y suplemento alimenticio para animales.
MY165879A (en) Gemstone and method for cutting the same
RS54744B1 (sr) Rastvorljivi funkcionalni heterodimeri mhc klase ii stabilizovani disulfidnom vezom
CL2020000763A1 (es) Proceso para la lixiviación ácida de metales preciosos y calcófilos.
AR112946A1 (es) Recuperación de metales preciosos y calcófilos
MX2009001548A (es) Metodo para generar azufre micronizado.
EP2110039A3 (en) Charm for a chain, chain and chain element provided with such a charm
HK1114101A1 (el)
CL2009001069A1 (es) Metodo para recuperar cobre de un concentrado de sulfuro de cobre que comprende enargita, dicho metodo comprende las etapas de añadir el concentrado y la pirita en una solucion de lixiviacion de sulfato acido, estando el concentrado y la pirita en forma particulada, y lixiviar el cobre del concentrado en la solucion de lixiviacion en presencia de un gas que contiene oxigeno.
ATE523360T1 (de) Gelenk- und/oder lagereinheit
CL2008002739A1 (es) Metodo que alimenta material en pasta cuya fase solida contiene sulfuro refractario y que comprende metal precioso, sulfuros, hg y halogeno, oxida a alta temperatura y presion, convierte sulfuros en sulfato y obtiene material con metal precioso oxidado, inhibiendo la disolucion de hg del material y recupera metal precioso.
EA200601576A1 (ru) Способ приготовления серы из сульфида водорода, содержащегося в природном газе или в попутном газе, и возможное захоронение полученной таким образом серы
HK1154032A1 (en) A process for the ultrapurification of alginates
NZ601616A (en) Method for producing interferon alpha 5
CN202043673U (zh) 皮带
HK1136755A1 (en) Watch bracelet
GR1005502B (el) Μηχανισμος παραγωγης ετοιμου οπλισμου μικρων διαστασεων καταλληλου για την ενισχυση της τοιχοποιιας(σεναζ)

Legal Events

Date Code Title Description
PG Patent granted