GEP20053660B - Novel Tyrosine Kinase Inhibitors - Google Patents
Novel Tyrosine Kinase InhibitorsInfo
- Publication number
- GEP20053660B GEP20053660B GE5363A GEAP2002005363A GEP20053660B GE P20053660 B GEP20053660 B GE P20053660B GE 5363 A GE5363 A GE 5363A GE AP2002005363 A GEAP2002005363 A GE AP2002005363A GE P20053660 B GEP20053660 B GE P20053660B
- Authority
- GE
- Georgia
- Prior art keywords
- tyrosine kinase
- kinase inhibitors
- novel tyrosine
- compounds
- kinase enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
1. Technical Result Increase in efficiency of treatment of diseases, which can be treated by inhibiting tyrosine kinase enzymes. 2. Essence Compounds of formula wherein X, Y, R1-R9 have the values indicated in the description; said compounds are capable of inhibiting tyrosine kinase enzymes thereby making them useful as anti-cancer agents. 3. Field of Application Medicine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27932701P | 2001-03-28 | 2001-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GEP20053660B true GEP20053660B (en) | 2005-11-10 |
Family
ID=23068491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GE5363A GEP20053660B (en) | 2001-03-28 | 2002-03-26 | Novel Tyrosine Kinase Inhibitors |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1381598A4 (en) |
JP (1) | JP2004534010A (en) |
KR (1) | KR20030083016A (en) |
CN (1) | CN1514833A (en) |
AR (1) | AR035804A1 (en) |
BG (1) | BG108206A (en) |
BR (1) | BR0208373A (en) |
CA (1) | CA2442428A1 (en) |
CZ (1) | CZ20032615A3 (en) |
EE (1) | EE200300475A (en) |
GE (1) | GEP20053660B (en) |
HR (1) | HRP20030844A2 (en) |
HU (1) | HUP0400323A2 (en) |
IL (1) | IL158041A0 (en) |
IS (1) | IS6968A (en) |
MX (1) | MXPA03008690A (en) |
NO (1) | NO20034308L (en) |
PE (1) | PE20021015A1 (en) |
PL (1) | PL373300A1 (en) |
RU (1) | RU2003131693A (en) |
SK (1) | SK12002003A3 (en) |
UY (1) | UY27234A1 (en) |
WO (1) | WO2002079192A1 (en) |
YU (1) | YU84603A (en) |
ZA (1) | ZA200307466B (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7081454B2 (en) * | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
JP2005518800A (en) | 2002-03-01 | 2005-06-30 | ブリストル−マイヤーズ スクイブ カンパニー | Transgenic non-human mammal expressing a constitutively activated tyrosine kinase receptor |
US6921821B2 (en) * | 2002-06-12 | 2005-07-26 | Abbott Laboratories | Antagonists of melanin concentrating hormone receptor |
WO2004050033A2 (en) * | 2002-12-02 | 2004-06-17 | Arqule, Inc. | Method of treating cancers |
US7189716B2 (en) | 2003-01-03 | 2007-03-13 | Bristol-Myers Squibb Company | Tyrosine kinase inhibitors |
WO2004069160A2 (en) * | 2003-01-28 | 2004-08-19 | Smithkline Beecham Corporation | Chemical compounds |
US7312215B2 (en) | 2003-07-29 | 2007-12-25 | Bristol-Myers Squibb Company | Benzimidazole C-2 heterocycles as kinase inhibitors |
AU2004268621C1 (en) * | 2003-08-29 | 2011-08-18 | Exelixis, Inc. | c-Kit modulators and methods of use |
US20050075358A1 (en) * | 2003-10-06 | 2005-04-07 | Carboni Joan M. | Methods for treating IGF1R-inhibitor induced hyperglycemia |
DE102004010207A1 (en) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | New 4-benzimidazolyl-3(2H)-pyridazinone derivatives are kinase inhibitors, especially useful for treatment of cancer |
ATE433979T1 (en) | 2004-04-02 | 2009-07-15 | Osi Pharm Inc | HETEROBICYCLIC PROTEIN KINASE INHIBITORS SUBSTITUTED WITH A 6,6-BICYCLIC RING |
MX2007007330A (en) * | 2004-12-16 | 2007-10-04 | Vertex Pharma | Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases. |
WO2006130657A2 (en) | 2005-05-31 | 2006-12-07 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7345178B2 (en) | 2005-08-04 | 2008-03-18 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
EP1919891B1 (en) * | 2005-08-29 | 2012-03-07 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
US7786130B2 (en) | 2005-08-29 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
US7786120B2 (en) | 2005-08-29 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
WO2007026720A1 (en) * | 2005-08-31 | 2007-03-08 | Taisho Pharmaceutical Co., Ltd. | Ring-fused pyrazole derivative |
US8575164B2 (en) | 2005-12-19 | 2013-11-05 | OSI Pharmaceuticals, LLC | Combination cancer therapy |
WO2007145203A1 (en) * | 2006-06-13 | 2007-12-21 | Daiichi Fine Chemical Co., Ltd. | Optically active 2-amino-1-(4-fluorophenyl)ethanol |
US8063225B2 (en) | 2006-08-14 | 2011-11-22 | Chembridge Corporation | Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
WO2008022747A1 (en) * | 2006-08-21 | 2008-02-28 | F. Hoffmann-La Roche Ag | Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents |
WO2008025526A1 (en) * | 2006-08-31 | 2008-03-06 | F. Hoffmann-La Roche Ag | Indole derivatives, their manufacture and use as pharmaceutical agents |
EP2145021A2 (en) | 2007-05-17 | 2010-01-20 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
CL2008001822A1 (en) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compounds derived from thiazolo [5,4-b] pyridine; pharmaceutical composition comprising said compounds; and use of the compound in the treatment of insulin resistance, metabolic syndrome, diabetes, among others. |
WO2009000489A1 (en) * | 2007-06-25 | 2008-12-31 | F. Hoffmann-La Roche Ag | Benzimidazole amido derivatives as kinase inhibitors |
EP2065380A1 (en) * | 2007-08-22 | 2009-06-03 | F.Hoffmann-La Roche Ag | Pyridoneamide derivatives as focal adhesion kinase (FAK) inhibitors and their use for the treatment of cancer |
US7816540B2 (en) * | 2007-12-21 | 2010-10-19 | Hoffmann-La Roche Inc. | Carboxyl- or hydroxyl-substituted benzimidazole derivatives |
MX2010007525A (en) * | 2008-01-22 | 2010-08-18 | Vernalis R&D Ltd | Indolyl- pyridone derivatives having checkpoint kinase 1 inhibitory activity. |
EP2283020B8 (en) | 2008-05-19 | 2012-12-12 | OSI Pharmaceuticals, LLC | Substituted imidazopyr-and imidazotri-azines |
US8343997B2 (en) | 2008-12-19 | 2013-01-01 | Sirtris Pharmaceuticals, Inc. | Thiazolopyridine sirtuin modulating compounds |
DE102010001064A1 (en) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and their use |
WO2010123792A1 (en) | 2009-04-20 | 2010-10-28 | Osi Pharmaceuticals, Inc. | Preparation of c-pyrazine-methylamines |
US8536180B2 (en) * | 2009-05-27 | 2013-09-17 | Abbvie Inc. | Pyrimidine inhibitors of kinase activity |
EP2494070A2 (en) | 2009-10-30 | 2012-09-05 | Bristol-Myers Squibb Company | Methods for treating cancer in patients having igf-1r inhibitor resistance |
MX337662B (en) * | 2010-10-06 | 2016-03-14 | Glaxosmithkline Llc | Benzimidazole derivatives as pi3 kinase inhibitors. |
WO2012061169A1 (en) * | 2010-11-01 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
EP2766497A1 (en) | 2011-10-13 | 2014-08-20 | Bristol-Myers Squibb Company | Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors |
SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
EP3010917B1 (en) | 2013-06-21 | 2018-01-31 | Zenith Epigenetics Ltd. | Novel substituted bicyclic compounds as bromodomain inhibitors |
JP6542212B2 (en) | 2013-07-31 | 2019-07-10 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
CN103936719A (en) * | 2014-05-14 | 2014-07-23 | 中国药科大学 | Preparation method and application of benzimidazoles derivatives |
CN108064274A (en) | 2014-07-30 | 2018-05-22 | 耶达研究及发展有限公司 | For cultivating the culture medium of multipotential stem cell |
CA2966298A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
JP2017538721A (en) | 2014-12-17 | 2017-12-28 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | Bromodomain inhibitors |
WO2016165808A1 (en) * | 2015-04-16 | 2016-10-20 | Merck Patent Gmbh | 3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one derivatives |
WO2020152686A1 (en) | 2019-01-23 | 2020-07-30 | Yeda Research And Development Co. Ltd. | Culture media for pluripotent stem cells |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
RS50340B (en) * | 1999-06-23 | 2009-11-10 | Sanofi-Aventis Deutschland Gmbh., | Substituted benzimidazole |
US7081454B2 (en) * | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
-
2002
- 2002-03-26 RU RU2003131693/04A patent/RU2003131693A/en not_active Application Discontinuation
- 2002-03-26 SK SK12002003A patent/SK12002003A3/en not_active Application Discontinuation
- 2002-03-26 KR KR10-2003-7012594A patent/KR20030083016A/en not_active Application Discontinuation
- 2002-03-26 IL IL15804102A patent/IL158041A0/en unknown
- 2002-03-26 MX MXPA03008690A patent/MXPA03008690A/en unknown
- 2002-03-26 CZ CZ20032615A patent/CZ20032615A3/en unknown
- 2002-03-26 JP JP2002577817A patent/JP2004534010A/en not_active Withdrawn
- 2002-03-26 HU HU0400323A patent/HUP0400323A2/en unknown
- 2002-03-26 CA CA002442428A patent/CA2442428A1/en not_active Abandoned
- 2002-03-26 GE GE5363A patent/GEP20053660B/en unknown
- 2002-03-26 EE EEP200300475A patent/EE200300475A/en unknown
- 2002-03-26 YU YU84603A patent/YU84603A/en unknown
- 2002-03-26 BR BR0208373-6A patent/BR0208373A/en not_active IP Right Cessation
- 2002-03-26 CN CNA028105168A patent/CN1514833A/en active Pending
- 2002-03-26 PL PL02373300A patent/PL373300A1/en not_active Application Discontinuation
- 2002-03-26 WO PCT/US2002/009402 patent/WO2002079192A1/en active Application Filing
- 2002-03-26 EP EP02723631A patent/EP1381598A4/en not_active Withdrawn
- 2002-03-27 PE PE2002000244A patent/PE20021015A1/en not_active Application Discontinuation
- 2002-03-27 UY UY27234A patent/UY27234A1/en not_active Application Discontinuation
- 2002-03-27 AR ARP020101167A patent/AR035804A1/en not_active Application Discontinuation
-
2003
- 2003-09-25 ZA ZA200307466A patent/ZA200307466B/en unknown
- 2003-09-26 BG BG108206A patent/BG108206A/en unknown
- 2003-09-26 NO NO20034308A patent/NO20034308L/en not_active Application Discontinuation
- 2003-09-26 IS IS6968A patent/IS6968A/en unknown
- 2003-10-17 HR HR20030844A patent/HRP20030844A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
YU84603A (en) | 2006-03-03 |
PE20021015A1 (en) | 2002-11-10 |
HUP0400323A2 (en) | 2005-11-28 |
IL158041A0 (en) | 2004-03-28 |
SK12002003A3 (en) | 2004-10-05 |
EE200300475A (en) | 2004-02-16 |
BG108206A (en) | 2004-11-30 |
UY27234A1 (en) | 2002-10-31 |
AR035804A1 (en) | 2004-07-14 |
CN1514833A (en) | 2004-07-21 |
JP2004534010A (en) | 2004-11-11 |
KR20030083016A (en) | 2003-10-23 |
EP1381598A4 (en) | 2008-03-19 |
CA2442428A1 (en) | 2002-10-10 |
RU2003131693A (en) | 2005-05-10 |
CZ20032615A3 (en) | 2004-03-17 |
BR0208373A (en) | 2005-02-22 |
ZA200307466B (en) | 2005-01-13 |
PL373300A1 (en) | 2005-08-22 |
EP1381598A1 (en) | 2004-01-21 |
IS6968A (en) | 2003-09-26 |
MXPA03008690A (en) | 2003-12-12 |
HRP20030844A2 (en) | 2005-08-31 |
WO2002079192A1 (en) | 2002-10-10 |
NO20034308L (en) | 2003-11-26 |
NO20034308D0 (en) | 2003-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GEP20053660B (en) | Novel Tyrosine Kinase Inhibitors | |
MXPA04000622A (en) | Pyrazolylcarboxanilides as fungicides. | |
GEP20022678B (en) | Bicyclic Heteroaromatic Compounds As Protein Tyrosine Kinase Inhibitors, their Pharmaceutical compositions and methods for Treatment | |
AP1649A (en) | Triamide-substituted heterobicyclic compounds. | |
AU2003226572A1 (en) | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | |
BR0307432B1 (en) | difluoromethylthiazolylcarboxanilides | |
WO2004030620A3 (en) | Novel tyrosine kinase inhibitors | |
MA27933A1 (en) | INHIBITORS OF AKT ACTIVITY | |
NZ539841A (en) | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | |
BG108181A (en) | Novel spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | |
ATE451376T1 (en) | COMPOSITIONS SUITABLE AS INHIBITORS OF PROTEIN KINASES | |
NO20030895L (en) | New use of dipeptidyl peptidase IV inhibitors | |
MY140031A (en) | Carbonyl compounds | |
MXPA05011643A (en) | 5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension. | |
DE60214703D1 (en) | THIAZOL COMPOUNDS SUITABLE AS INHIBITORS OF PROTEIN KINASES | |
TW200514776A (en) | Aminotriazole compounds useful as inhibitors of protein kinases | |
DK1480961T3 (en) | Glutaminyl-based DPIV inhibitors | |
MXPA05005223A (en) | Diaminotriazoles useful as inhibitors of protein kinases. | |
HK1079519A1 (en) | Furyl compounds | |
TW200613306A (en) | Imidazotriazines as protein kinase inhibitors | |
GEP20063805B (en) | Alkyne-Arylnaphthyridin-4-one as Phosphodiesterase-4 Inhibitors | |
TW200510325A (en) | 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof | |
WO2003106450A8 (en) | Phenylaminopyrimidines and their use as rho-kinase inhibitors | |
BRPI0416030A (en) | hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | |
RS19504A (en) | Novel compounds and compositions as cathepsin inhibitors |