GEP20043267B - Adenosine Receptor Antagonists, Methods of Making and Using the Same - Google Patents

Adenosine Receptor Antagonists, Methods of Making and Using the Same

Info

Publication number
GEP20043267B
GEP20043267B GEAP20006495A GEAP2000006495A GEP20043267B GE P20043267 B GEP20043267 B GE P20043267B GE AP20006495 A GEAP20006495 A GE AP20006495A GE AP2000006495 A GEAP2000006495 A GE AP2000006495A GE P20043267 B GEP20043267 B GE P20043267B
Authority
GE
Georgia
Prior art keywords
making
methods
same
receptor antagonists
adenosine receptor
Prior art date
Application number
GEAP20006495A
Inventor
Gnanasambandam Kumaravel
James E Dowling
Russell C Petter
Carol Ensinger
Original Assignee
Biogen Inc Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc Us filed Critical Biogen Inc Us
Publication of GEP20043267B publication Critical patent/GEP20043267B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Abstract

1. Technical Result Increase in treatment efficiency. 2. Essence A compounds of Formula (I), wherein R1, R2, R5 , X1, X2, Z have the values indicated in the description. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, etc. 3. Field of Application Medicine.
GEAP20006495A 1999-11-12 2000-11-13 Adenosine Receptor Antagonists, Methods of Making and Using the Same GEP20043267B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16528399P 1999-11-12 1999-11-12

Publications (1)

Publication Number Publication Date
GEP20043267B true GEP20043267B (en) 2004-06-25

Family

ID=22598257

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20006495A GEP20043267B (en) 1999-11-12 2000-11-13 Adenosine Receptor Antagonists, Methods of Making and Using the Same

Country Status (33)

Country Link
US (4) US6605600B1 (en)
EP (2) EP1775297A3 (en)
JP (1) JP2003513976A (en)
KR (1) KR100845488B1 (en)
CN (1) CN1187354C (en)
AT (1) ATE353328T1 (en)
AU (1) AU784528B2 (en)
BG (1) BG106693A (en)
BR (1) BR0015540A (en)
CA (1) CA2390590C (en)
CY (1) CY1106560T1 (en)
CZ (1) CZ20021615A3 (en)
DE (1) DE60033310T2 (en)
DK (1) DK1230241T3 (en)
EA (1) EA010260B1 (en)
EE (1) EE200200248A (en)
ES (1) ES2281367T3 (en)
GE (1) GEP20043267B (en)
HK (1) HK1049153B (en)
HU (1) HUP0203371A3 (en)
IL (1) IL149486A0 (en)
IS (1) IS6380A (en)
MX (1) MXPA02004795A (en)
NO (1) NO20022237L (en)
NZ (2) NZ519427A (en)
PL (1) PL198156B1 (en)
PT (1) PT1230241E (en)
SK (1) SK6622002A3 (en)
TR (1) TR200301062T2 (en)
UA (1) UA77937C2 (en)
WO (1) WO2001034604A2 (en)
YU (1) YU33702A (en)
ZA (1) ZA200203702B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
WO2001034604A2 (en) * 1999-11-12 2001-05-17 Biogen, Inc. Adenosine receptor antagonists and methods of making and using the same
MEP42208A (en) * 1999-11-12 2011-02-10 Biogen Idec Inc Polycycloalkylpurines as adenosine receptor antagonists
UA84404C2 (en) * 2002-06-12 2008-10-27 Байоджен Айдек Ма Инк. Method of treating ischemia reperfusion injury using adenosine receptor antagonists
US20040106797A1 (en) * 2002-07-19 2004-06-03 Pascal Druzgala Novel xanthines having adenosine A1-receptor antagonist properties
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
BRPI0409307A (en) * 2003-04-14 2006-04-25 Pfizer Prod Inc 3-azabicyclo [3.2.1] octane derivatives
NZ543109A (en) * 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
US7247639B2 (en) * 2003-06-06 2007-07-24 Endacea, Inc. A1 adenosine receptor antagonists
JP2009528389A (en) * 2006-03-02 2009-08-06 シーブイ・セラピューティクス・インコーポレイテッド A2A adenosine receptor antagonist
WO2007117549A2 (en) * 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine a1 receptor antagonists and anticonvulsants
ES2525076T3 (en) 2006-05-19 2014-12-17 Abbvie Bahamas Ltd. Derivatives of azabicyclic alkanes substituted with condensed bicycloheterocycles active in the CNS
EP2035009A1 (en) * 2006-06-16 2009-03-18 Novacardia, Inc. Prolonged improvement of renal function comprising infrequent administration of an aa1ra
US20090197900A1 (en) * 2007-03-29 2009-08-06 Howard Dittrich Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20080242684A1 (en) * 2007-03-29 2008-10-02 Howard Dittrich Methods of administration of adenosine a1 receptor antagonists
US20090228097A1 (en) * 2008-03-07 2009-09-10 Abbott Cardiovascular Systems Inc. A1 Adenosine Receptor Antagonist-Coated Implantable Medical Device
CN114790164B (en) 2021-08-13 2022-12-27 苏州璞正医药有限公司 Substituted isoindoline-1,3-diketone PDE4 inhibitor and pharmaceutical application thereof

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DE4019892A1 (en) 1990-06-22 1992-01-02 Boehringer Ingelheim Kg New xanthine derivs. are selective A1 adenosine antagonists - useful for treating CNS disorders (e.g. senile dementia) and heart and circulation disorders
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US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
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DE19816857A1 (en) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Novel adenosine antagonists useful in treatment of e.g. neurodegenerative, pulmonary, renal and cardiovascular disorders
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Also Published As

Publication number Publication date
SK6622002A3 (en) 2003-02-04
WO2001034604A2 (en) 2001-05-17
UA77937C2 (en) 2007-02-15
CN1187354C (en) 2005-02-02
NZ519427A (en) 2003-08-29
CY1106560T1 (en) 2012-01-25
EE200200248A (en) 2003-06-16
EA200200562A1 (en) 2002-10-31
EA010260B1 (en) 2008-06-30
NO20022237D0 (en) 2002-05-10
TR200301062T2 (en) 2003-09-22
PL356044A1 (en) 2004-06-14
DK1230241T3 (en) 2007-06-04
DE60033310D1 (en) 2007-03-22
BR0015540A (en) 2002-07-23
IS6380A (en) 2002-05-10
US20050222179A1 (en) 2005-10-06
CZ20021615A3 (en) 2002-08-14
CN1399636A (en) 2003-02-26
US6605600B1 (en) 2003-08-12
EP1230241A2 (en) 2002-08-14
HUP0203371A2 (en) 2003-02-28
BG106693A (en) 2003-01-31
CA2390590A1 (en) 2001-05-17
HK1049153A1 (en) 2003-05-02
KR20020049043A (en) 2002-06-24
HK1049153B (en) 2007-09-28
IL149486A0 (en) 2002-11-10
DE60033310T2 (en) 2007-11-22
KR100845488B1 (en) 2008-07-10
NZ527918A (en) 2005-05-27
EP1775297A3 (en) 2008-12-03
CA2390590C (en) 2010-03-16
PL198156B1 (en) 2008-05-30
EP1775297A2 (en) 2007-04-18
NO20022237L (en) 2002-07-12
US20030225038A1 (en) 2003-12-04
ES2281367T3 (en) 2007-10-01
US20080004293A1 (en) 2008-01-03
HUP0203371A3 (en) 2005-02-28
ZA200203702B (en) 2003-10-29
AU784528B2 (en) 2006-04-27
MXPA02004795A (en) 2005-07-01
YU33702A (en) 2005-03-15
EP1230241B1 (en) 2007-02-07
ATE353328T1 (en) 2007-02-15
AU2042101A (en) 2001-06-06
WO2001034604A3 (en) 2002-01-10
JP2003513976A (en) 2003-04-15
PT1230241E (en) 2007-05-31

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