GB994275A - Improvements in or relating to endoprostheses - Google Patents
Improvements in or relating to endoprosthesesInfo
- Publication number
- GB994275A GB994275A GB2108362A GB2108362A GB994275A GB 994275 A GB994275 A GB 994275A GB 2108362 A GB2108362 A GB 2108362A GB 2108362 A GB2108362 A GB 2108362A GB 994275 A GB994275 A GB 994275A
- Authority
- GB
- United Kingdom
- Prior art keywords
- proteins
- treated
- moulded
- plasticizer
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
Abstract
A protein composition is moulded under pressure to form surgical endoprosthesis absorbable in the body, the composition comprising a mixture of human or animal proteins and a plasticizer, the proteins being albumin, actomyosin, myosin, actin, collagen, elastin or fibrin. The protein, which is isolated by conventional methods, is treated with a dehydrating agent, e.g. acetone or ethanol, dried and ground. Different proteins are mixed in desired proportions to provide materials of desired properties. The powdered proteins are then mixed with a plasticizer and moulded. Plasticizers used are dihydric and trihydric alcohols, ethylene glycol, propylene glycol or glycerol. The moulded material may be treated to increase its resistance to attack by tissue enzymes or to improve its elastic properties.ALSO:Absorbable endoprostheses e.g. pins, nails, screws, plugs, tubes for substitute trachea, sleeves, cups, buttons, rings, bars, are made by moulding under pressure a mixture of powdered human or animal protein and a plasticizer, the proteins being selected from albumin, actomyosin, myosin, actin, collagen, elastin or fibrin. The proteins are isolated from blood, bone or tissue by conventional methods, treated with a dehydrating agent, e.g. acetone or ethanol, dried and ground. Different proteins are mixed in desired proportions to provide materials of different properties. The powdered proteins are then mixed with a plasticizer and moulded to the desired shape. Plasticizers used are dihydric and trihydric alcohols, ethylene glycol, propylene glycol or glycerol. The moulded prostheses are treated in a bath with aluminium or chromium salts, formaldehyde, acetaldehyde, ethylene chloride or epoxides to increase their resistance to attach by tissue enzymes. They may also be treated with ethylene glycol or glycerol to improve their elastic properties.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUGE000368 | 1961-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB994275A true GB994275A (en) | 1965-06-02 |
Family
ID=10996514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2108362A Expired GB994275A (en) | 1961-05-31 | 1962-05-31 | Improvements in or relating to endoprostheses |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1745676B1 (en) |
DK (1) | DK107887C (en) |
GB (1) | GB994275A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0069156A1 (en) * | 1981-07-02 | 1983-01-12 | Intermedicat GmbH | Method for the preparation of transplants with higher biological stability |
EP0169259A1 (en) * | 1984-07-25 | 1986-01-29 | Surgical Patent Products Inc. Ltd. | Vascular prostheses for dry preservation, method of conditioning and their use in surgery |
WO1998040112A1 (en) * | 1997-03-10 | 1998-09-17 | Meadox Medicals, Inc. | Self-aggregating protein compositions and use as sealants |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE358540C (en) * | 1915-08-01 | 1922-09-12 | Gottfried Diesser | Process for the production of water-insoluble bodies from glycerine and albumins |
US2385803A (en) * | 1942-02-09 | 1945-10-02 | Research Corp | Process for the manufacture of plastic compositions |
DE849165C (en) * | 1951-03-01 | 1952-09-11 | Nordmark Werke Gmbh | Process for the production of threads, films and foams from fibrin |
-
1962
- 1962-03-08 DK DK108762A patent/DK107887C/en active
- 1962-05-28 DE DE19621745676 patent/DE1745676B1/en active Pending
- 1962-05-31 GB GB2108362A patent/GB994275A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0069156A1 (en) * | 1981-07-02 | 1983-01-12 | Intermedicat GmbH | Method for the preparation of transplants with higher biological stability |
EP0169259A1 (en) * | 1984-07-25 | 1986-01-29 | Surgical Patent Products Inc. Ltd. | Vascular prostheses for dry preservation, method of conditioning and their use in surgery |
WO1998040112A1 (en) * | 1997-03-10 | 1998-09-17 | Meadox Medicals, Inc. | Self-aggregating protein compositions and use as sealants |
Also Published As
Publication number | Publication date |
---|---|
DK107887C (en) | 1967-07-17 |
DE1745676B1 (en) | 1970-07-02 |
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