GB985482A - 2-methylene testosterone derivatives and methods for producing the same - Google Patents
2-methylene testosterone derivatives and methods for producing the sameInfo
- Publication number
- GB985482A GB985482A GB161761A GB161761A GB985482A GB 985482 A GB985482 A GB 985482A GB 161761 A GB161761 A GB 161761A GB 161761 A GB161761 A GB 161761A GB 985482 A GB985482 A GB 985482A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- general formula
- hydroxymethylene
- above significance
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises steroids of the general formula <FORM:0985482/C2/1> wherein Y represents hydrogen or the methyl group and Z represents a hydroxymethylene, alkanoyloxymethylene, alkyl substituted hydroxymethylene (C(a -alkyl)OH), carbonyl or ethynyl substituted hydroxymethylene (C(a -CCH)OH) group, and a process for the preparation of steroids of the general formula <FORM:0985482/C2/2> wherein Y and R have the above significance, by treating 2-alkoxyoxalyl-steroids of the general formula <FORM:0985482/C2/3> wherein Y and R have the above significance, with formaldehyde in the presence of a basic catalyst, a process for the production of steroids of the general formula <FORM:0985482/C2/4> wherein Y has the above significance, by acylating the corresponding 17b -hydroxy-steroid, and a process for the preparation of steroids of the general formula <FORM:0985482/C2/5> wherein Y has the above significance, by oxidizing the corresponding 17b -hydroxy compound. The alkyl groups contain 1 to 3 carbon atoms and the alkanoyloxy groups contain not more than 4 carbon atoms. Therapeutic compositions suitable for oral or parenteral administration having anabolic activity contain as the active ingredient a steroid of the first general formula above. 2-Alkoxyoxalyl-steroids of the third general formula above are prepared by treating the corresponding steroids unsubstituted at the 2-position with an excess of dialkyl oxalate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB161761A GB985482A (en) | 1961-01-13 | 1961-01-13 | 2-methylene testosterone derivatives and methods for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB161761A GB985482A (en) | 1961-01-13 | 1961-01-13 | 2-methylene testosterone derivatives and methods for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB985482A true GB985482A (en) | 1965-03-10 |
Family
ID=9725044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB161761A Expired GB985482A (en) | 1961-01-13 | 1961-01-13 | 2-methylene testosterone derivatives and methods for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB985482A (en) |
-
1961
- 1961-01-13 GB GB161761A patent/GB985482A/en not_active Expired
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