GB981701A - New 2-phenylamino-4h-5,6-dihydro-1,3-thiazine derivatives - Google Patents
New 2-phenylamino-4h-5,6-dihydro-1,3-thiazine derivativesInfo
- Publication number
- GB981701A GB981701A GB2639663A GB2639663A GB981701A GB 981701 A GB981701 A GB 981701A GB 2639663 A GB2639663 A GB 2639663A GB 2639663 A GB2639663 A GB 2639663A GB 981701 A GB981701 A GB 981701A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- reacting
- amino
- dihydro
- isothiocyanate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of general formula <FORM:0981701/C2/1> wherein R is a substituted phenyl radical; and their acid addition salts; and their preparation by (1) reacting a phenyl isothiocyanate with 4-amino-butan-2-ol to give the corresponding thiourea which is then treated with an acid, (2) reacting a phenyl isothiocyanate with a 4-amino - 2 - halo - butane, (3) reacting an N-phenyl-thiourea with a 1,3-dihalobutane or with a 4-amino-2-halobutane salt, (4) reacting a phenyl amine with a 3-halobutyl isothiocyanate, and (5) reacting a phenyl amine with a 2-amino-, 2 - mercapto -, or 2 - alkylmercapto - 6-methyl - 4H - 5,6 - dihydro - 1,3 - thiazine, optionally in the presence of an acid. 2 - Phenylamino - 6 - methyl - 4H - 5,6 - dihydro - 1,3 - thiazin may be prepared from 3-chlorobutylamine and phenyl isothiocyanate. 3-Chlorobutyl isothiocyanate is prepared from the amine and thiophosgene. 2 - Amino - 6 - methyl - 4H - 5,6 - dihydro-1,3 - thiazine, and thence the hydrobromide, are obtained from 3-thiocyano-butylamine hydrobromide with aqueous alkali.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF37233A DE1191820B (en) | 1962-07-05 | 1962-07-05 | Process for the preparation of derivatives of 2-phenylamino-4 H-5, 6-dihydro-1, 3-thiazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB981701A true GB981701A (en) | 1965-01-27 |
Family
ID=7096793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2639663A Expired GB981701A (en) | 1962-07-05 | 1963-07-03 | New 2-phenylamino-4h-5,6-dihydro-1,3-thiazine derivatives |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT244969B (en) |
| BE (1) | BE634553A (en) |
| CH (2) | CH443304A (en) |
| DE (1) | DE1191820B (en) |
| DK (1) | DK109776C (en) |
| GB (1) | GB981701A (en) |
| SE (1) | SE311904B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816414A (en) * | 1972-11-03 | 1974-06-11 | Squibb & Sons Inc | Omikron-acylamino-n-(2-thiazolin-2-yl and 2-thiazin-2-yl)anilines and derivatives thereof |
-
0
- BE BE634553D patent/BE634553A/xx unknown
-
1962
- 1962-07-05 DE DEF37233A patent/DE1191820B/en active Pending
-
1963
- 1963-05-31 CH CH689963A patent/CH443304A/en unknown
- 1963-06-06 CH CH710263A patent/CH433318A/en unknown
- 1963-06-26 DK DK305663A patent/DK109776C/en active
- 1963-07-03 GB GB2639663A patent/GB981701A/en not_active Expired
- 1963-07-04 SE SE743963A patent/SE311904B/xx unknown
- 1963-07-05 AT AT536863A patent/AT244969B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| BE634553A (en) | |
| SE311904B (en) | 1969-06-30 |
| CH443304A (en) | 1967-09-15 |
| DK109776C (en) | 1968-07-01 |
| CH433318A (en) | 1967-04-15 |
| AT244969B (en) | 1966-02-10 |
| DE1191820B (en) | 1965-04-29 |
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