GB979007A - Benzenesulphonyl-semicarbazides and process for their manufacture - Google Patents
Benzenesulphonyl-semicarbazides and process for their manufactureInfo
- Publication number
- GB979007A GB979007A GB37347/62A GB3734762A GB979007A GB 979007 A GB979007 A GB 979007A GB 37347/62 A GB37347/62 A GB 37347/62A GB 3734762 A GB3734762 A GB 3734762A GB 979007 A GB979007 A GB 979007A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzenesulphonyl
- reacting
- benzenesulphonamide
- conversely
- carbamic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0979007/C1/1> and physiologically acceptable salts thereof with bases or acids, wherein X and Y are halogen atoms or C1- 6 alkyl or alkoxy groups and -Z-Z1- is an alkylene chain having 3-7 carbon atoms, optionally bearing C1- 4 alkyl substituents, and their preparation by (a) reacting a benzenesulphonyl isocyanate with an N,N-alkylenehydrazine or, conversely, reacting a benzenesulphonamide with an alkyleneiminoisocyanate, (b) reacting an N,N-alkylene hydrazine with a compound which reacts as a benzenesulphonylisocyanate, such as a benzenesulphonyl carbamic ester, monothiocarbamic ester or carbamic halide, or conversely, reacting the corresponding alkyleneimino carbamic derivatives with a benzenesulphonamide, (c) reacting a benzenesulphonyl urea which may be N1-substituted by alkyl, aryl or acyl radicals, or a bis-(benzenesulphonyl)-urea, with an N,N-alkylenehydrazine, or conversely, reacting an N1,N1-alkylene-semicarbazide, optionally substituted on the N4-atom, with a benzenesulphonamide, (d) hydrolyzing the corresponding 1-benzenesulphonyl-3-alkyleneimine-parabanic acid or (e) desulphurizing the corresponding benzenesulphonyl-thiosemicarbazide compound e.g. by reaction with oxides, heavy metal salts or oxidizing agents such as hydrogen peroxide, sodium peroxide or nitrous acid. Pharmaceutical preparations for the oral treatment of diabetes mellitus comprise the above compounds of the invention in admixture or conjunction with a carrier, preferably in the form of tablets.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0035040 | 1961-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB979007A true GB979007A (en) | 1965-01-01 |
Family
ID=7095831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37347/62A Expired GB979007A (en) | 1961-10-03 | 1962-10-02 | Benzenesulphonyl-semicarbazides and process for their manufacture |
Country Status (4)
| Country | Link |
|---|---|
| CH (3) | CH466281A (en) |
| DK (2) | DK101978C (en) |
| FR (1) | FR2837M (en) |
| GB (1) | GB979007A (en) |
-
1962
- 1962-10-01 CH CH972166A patent/CH466281A/en unknown
- 1962-10-01 CH CH1151862A patent/CH418327A/en unknown
- 1962-10-01 CH CH972066A patent/CH466280A/en unknown
- 1962-10-02 DK DK330363AA patent/DK101978C/en active
- 1962-10-02 DK DK330163AA patent/DK102801C/en active
- 1962-10-02 GB GB37347/62A patent/GB979007A/en not_active Expired
-
1963
- 1963-10-12 FR FR920243A patent/FR2837M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK102801C (en) | 1965-10-11 |
| CH466280A (en) | 1968-12-15 |
| CH466281A (en) | 1968-12-15 |
| DK101978C (en) | 1965-06-21 |
| CH418327A (en) | 1966-08-15 |
| FR2837M (en) | 1964-10-12 |
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