GB962025A - Process for preparing penicillins - Google Patents
Process for preparing penicillinsInfo
- Publication number
- GB962025A GB962025A GB1943762A GB1943762A GB962025A GB 962025 A GB962025 A GB 962025A GB 1943762 A GB1943762 A GB 1943762A GB 1943762 A GB1943762 A GB 1943762A GB 962025 A GB962025 A GB 962025A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- hydroxy
- prepared
- reacting
- penicillins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Penicillins of the formula: <FORM:0962025/C1/1> and non-toxic salts thereof, wherein R is a phenyl, substituted phenyl or alkyl group, are prepared by a process which comprises reacting 6-aminopenicillanic acid with an acid azide of the formula: <FORM:0962025/C1/2> Examples describe the production of a -hydroxy-, a -hydroxy-o-methoxy-, p-chloro-a -hydroxy- and a , p-dihydroxy-benzyl penicillins from the corresponding mandelic acid azides. The azides of mandelic, o-methoxymandelic, p-chloromandelic and p-hydroxymandelic acids are prepared by reacting the corresponding acid hydrazides with sodium nitrite in dilute acid solution. The acid hydrazides are prepared by reacting the methyl esters of the acids with hydrazine hydrate. Specification 880,042 is referred to.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1943762A GB962025A (en) | 1962-05-21 | 1962-05-21 | Process for preparing penicillins |
SE550463A SE327403B (en) | 1962-05-21 | 1963-05-17 | |
CH632763A CH431533A (en) | 1962-05-21 | 1963-05-20 | Process for the production of penicillins |
FR935350A FR1393245A (en) | 1962-05-21 | 1963-05-20 | Process for the preparation of penicillins |
DK242763A DK118244B (en) | 1962-05-21 | 1963-05-21 | Process for the preparation of α-hydroxypenicillins or salts thereof. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1943762A GB962025A (en) | 1962-05-21 | 1962-05-21 | Process for preparing penicillins |
Publications (1)
Publication Number | Publication Date |
---|---|
GB962025A true GB962025A (en) | 1964-06-24 |
Family
ID=10129371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1943762A Expired GB962025A (en) | 1962-05-21 | 1962-05-21 | Process for preparing penicillins |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH431533A (en) |
DK (1) | DK118244B (en) |
GB (1) | GB962025A (en) |
SE (1) | SE327403B (en) |
-
1962
- 1962-05-21 GB GB1943762A patent/GB962025A/en not_active Expired
-
1963
- 1963-05-17 SE SE550463A patent/SE327403B/xx unknown
- 1963-05-20 CH CH632763A patent/CH431533A/en unknown
- 1963-05-21 DK DK242763A patent/DK118244B/en unknown
Also Published As
Publication number | Publication date |
---|---|
SE327403B (en) | 1970-08-24 |
DK118244B (en) | 1970-07-27 |
CH431533A (en) | 1967-03-15 |
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