GB957542A - Cycloalkenyl ethers of 17ª‰-hydroxy androstanes - Google Patents
Cycloalkenyl ethers of 17ª‰-hydroxy androstanesInfo
- Publication number
- GB957542A GB957542A GB1407862A GB1407862A GB957542A GB 957542 A GB957542 A GB 957542A GB 1407862 A GB1407862 A GB 1407862A GB 1407862 A GB1407862 A GB 1407862A GB 957542 A GB957542 A GB 957542A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- hydroxy
- analogues
- grouping
- dehydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 17-11-cycloalkenyl ethers of 17b -hydroxy-androstanes of the general formula: <FORM:0957542/C2/1> wherein n is 1 or 2 and S represents one of the following groups: <FORM:0957542/C2/2> <FORM:0957542/C2/3> <FORM:0957542/C2/4> <FORM:0957542/C2/5> <FORM:0957542/C2/6> <FORM:0957542/C2/7> <FORM:0957542/C2/8> <FORM:0957542/C2/9> and the D 1-, D 1,4-and D 4,6-dehydro analogues of the compounds having grouping (a); the D 4-dehydro analogues of the compounds having grouping (a) and the corresponding 9a -fluoro-11b -hydroxy, 11b -hydroxy and 11-keto D 4-compounds; the D 4- and D 5(10)-dehydro analogues of the compounds having the grouping (b); the D 1-, D 4-, D 1,4- and D 5(6)- analogues of the compounds having the formula (c) and the lower alkyl ethers and lower alkanoyl esters of the compounds having the grouping (c) as well as of the various dehydro analogues thereof; and the 19-nor-D 4-dehydro analogues of the compounds having the formula (d); and the preparation thereof by reacting a corresponding 17b -hydroxy-steroid having any 3-hydroxy group protected as a lower alkyl ether or a lower alkanoyl ester and an acetal, hemiacetal or enol ether of cyclopentanone or of cyclohexanone derived from an aliphatic alcohol at a temperature higher than 80 DEG C. and thereafter, if desired, hydrolysing a 3-ester group in an alkaline medium. By "lower alkyl" is meant a saturated hydrocarbon radical containing 1 to 5 carbon atoms, and by "lower alkanoyl" is meant the acyl residue of an alkanoic acid containing 1 to 3 carbon atoms. The above process may be extended in the case of a product containing a 3-keto group by reducing the said keto group to a 3-hydroxy group by means of a conventional reduction method, for example by reducing with lithium aluminium hydride or sodium borohydride.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1220561 | 1961-04-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB957542A true GB957542A (en) | 1964-05-06 |
Family
ID=11139567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1407862A Expired GB957542A (en) | 1961-04-12 | 1962-04-11 | Cycloalkenyl ethers of 17ª‰-hydroxy androstanes |
Country Status (4)
Country | Link |
---|---|
AT (1) | AT248623B (en) |
BR (1) | BR6237940D0 (en) |
ES (1) | ES276601A1 (en) |
GB (1) | GB957542A (en) |
-
1962
- 1962-03-30 AT AT261362A patent/AT248623B/en active
- 1962-04-11 GB GB1407862A patent/GB957542A/en not_active Expired
- 1962-04-11 BR BR13794062A patent/BR6237940D0/en unknown
- 1962-04-11 ES ES276601A patent/ES276601A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES276601A1 (en) | 1962-10-01 |
AT248623B (en) | 1966-08-10 |
BR6237940D0 (en) | 1973-05-24 |
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