GB953131A - Leptospira vaccines - Google Patents

Leptospira vaccines

Info

Publication number
GB953131A
GB953131A GB2396561A GB2396561A GB953131A GB 953131 A GB953131 A GB 953131A GB 2396561 A GB2396561 A GB 2396561A GB 2396561 A GB2396561 A GB 2396561A GB 953131 A GB953131 A GB 953131A
Authority
GB
United Kingdom
Prior art keywords
leptospira
saline solution
cells
buffered aqueous
aqueous saline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2396561A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB953131A publication Critical patent/GB953131A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention comprises a leptospira vaccine consisting essentially of killed leptospira cells suspended in a buffered aqueous saline solution having a pH of about 7.1 to 7.3 in a concentration providing a bacterial count of approximately 200 billion 1,000 billion per mil said vaccine being substantially free of rabbit or other animal serum. The vaccine is prepared from a leptospira culture by physically separating a major portion of the animal serum from the leptospira cells e.g. by centrifugation, and re-suspending the separated leptospira cells in a buffered aqueous saline solution especially one having a pH of 7.1 to 7.3. Preferably, the separated leptospira cells are washed with a first buffered aqueous saline solution prior to resuspension in a second buffered aqueous saline solution. The preferred aqueous solution of saline contains sodium chloride, disodium monohydrogen phosphate and monosodium dihydrogen phosphate in such proportions as to provide a pH of 7.1 to 7.3. The term "leptospira" includes any pathogenic organism of the genus Leptospira and includes Leptospira pomona, Leptospira canicola, Leptospira icterohaemorrhagiae and Leptospira grippotyphosa. The vaccines are free from anaphylactoid reactions after injection into cattle.
GB2396561A 1960-07-14 1961-07-03 Leptospira vaccines Expired GB953131A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4277960A 1960-07-14 1960-07-14

Publications (1)

Publication Number Publication Date
GB953131A true GB953131A (en) 1964-03-25

Family

ID=21923710

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2396561A Expired GB953131A (en) 1960-07-14 1961-07-03 Leptospira vaccines

Country Status (1)

Country Link
GB (1) GB953131A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188936A1 (en) * 2011-08-08 2013-12-27 Bio-Pronto-Industria E Comercio De Produtos Biologicos Ltda - Epp Leptospirosis laboratory diagnostic medium and vaccine against animal leptospirosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188936A1 (en) * 2011-08-08 2013-12-27 Bio-Pronto-Industria E Comercio De Produtos Biologicos Ltda - Epp Leptospirosis laboratory diagnostic medium and vaccine against animal leptospirosis

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