GB952091A - Process for the production of hypoxanthine derivatives - Google Patents

Process for the production of hypoxanthine derivatives

Info

Publication number
GB952091A
GB952091A GB3977160A GB3977160A GB952091A GB 952091 A GB952091 A GB 952091A GB 3977160 A GB3977160 A GB 3977160A GB 3977160 A GB3977160 A GB 3977160A GB 952091 A GB952091 A GB 952091A
Authority
GB
United Kingdom
Prior art keywords
adenine
auxotroph
inosine
growth
bacillus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3977160A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Publication of GB952091A publication Critical patent/GB952091A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Abstract

Hypoxanthine, inosine and/or inosine-51-monophosphate are produced by cultivating an adenine-requiring auxotroph of a microorganism in a medium containing a growth-limiting amount of adenine and substantially large amounts of other nutrient sources than are required for propagation of said auxotroph, and continuing cultivation after growth has substantially ceased in order to accumulate the desired products. In a modification, the auxotroph is grown in a complete medium and the resulting cells cultivated in a medium containing substantially no adenine as a non-proliferating cell suspension. The products may be recovered from the cells or the culture medium. Examples describe the use of auxotrophs of Bacillus subtilis, Saccharomyces cereviciae, Escherichia coli. Bacillus megatherium, Bacillus cereus, Torula utilis, Streptomyces fradiae, Penicillium citrinum and Aspergillus oryzae obtained by radiation induced mutation of the parent strains.
GB3977160A 1959-11-24 1960-11-18 Process for the production of hypoxanthine derivatives Expired GB952091A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3639259 1959-11-24

Publications (1)

Publication Number Publication Date
GB952091A true GB952091A (en) 1964-03-11

Family

ID=12468566

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3977160A Expired GB952091A (en) 1959-11-24 1960-11-18 Process for the production of hypoxanthine derivatives

Country Status (2)

Country Link
CH (1) CH402871A (en)
GB (1) GB952091A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734843A1 (en) * 1995-06-02 1996-12-06 Centre Nat Rech Scient Bio-conversion of substrate with microbe auxotrophic for cpd. in medium deficient in this cpd.
EP1186664A2 (en) * 2000-08-08 2002-03-13 Roche Vitamins AG Process for producing a fermentation product
US20150004670A1 (en) * 2013-06-27 2015-01-01 The Board Of Regents For Oklahoma State University Methods for continuous enzyme production using a filamentous fungus with inhibited growth

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734843A1 (en) * 1995-06-02 1996-12-06 Centre Nat Rech Scient Bio-conversion of substrate with microbe auxotrophic for cpd. in medium deficient in this cpd.
EP1186664A2 (en) * 2000-08-08 2002-03-13 Roche Vitamins AG Process for producing a fermentation product
EP1186664A3 (en) * 2000-08-08 2002-03-20 Roche Vitamins AG Process for producing a fermentation product
US6656721B1 (en) 2000-08-08 2003-12-02 Roche Vitamins, Inc. Polynucleotide portions of the biotin operon from B. subtilis for use in enhanced fermentation
KR100841890B1 (en) * 2000-08-08 2008-06-27 디에스엠 아이피 어셋츠 비.브이. Process for producing a target fermentation product
US7695949B2 (en) 2000-08-08 2010-04-13 Dsm Ip Assets B.V. Process for producing a target fermentation product
US20150004670A1 (en) * 2013-06-27 2015-01-01 The Board Of Regents For Oklahoma State University Methods for continuous enzyme production using a filamentous fungus with inhibited growth

Also Published As

Publication number Publication date
CH402871A (en) 1965-11-30

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