GB938322A - A process for the production of 5-guanylic acid - Google Patents

A process for the production of 5-guanylic acid

Info

Publication number
GB938322A
GB938322A GB1176562A GB1176562A GB938322A GB 938322 A GB938322 A GB 938322A GB 1176562 A GB1176562 A GB 1176562A GB 1176562 A GB1176562 A GB 1176562A GB 938322 A GB938322 A GB 938322A
Authority
GB
United Kingdom
Prior art keywords
guanylic acid
nucleotides
guanosine
phosphate
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1176562A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of GB938322A publication Critical patent/GB938322A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

51-Guanylic acid is prepared by adding to a solution containing guanosine and a phosphate donor comprising one or more aromatic phosphates and/or one or more nucleotides other than 51-guanylic acid an enzyme source comprising or obtained from cells of a species of microorganism selected from the genera Flavobacterium, Serratia, Staphylococcus and Pseudomonas, allowing biochemical phosphorylation of the guanosine to take place while maintaining the pH from 3,5 to 4,0 and thereafter recovering the accumulated 51-guanylic acid. Suitable aromatic phosphates include nitrophenyl phosphates, phenyl phosphate, benzyl phosphate and their salts. Copper and/or zinc ions are preferably present. The product may be recovered by separating the cells, extracting liberated phenol with an organic solvent, absorbing the guanylic acid on an ion-exchange resin, eluting with a mixture of HCl and NaCl, concentrating the eluate and adding ethanol to precipitate sodium 51-guanylate. The guanosine starting material may be derived from a fermentation process and may contain other nucleotides which are converted to their nucleotides such as 51-inosinic and 51-adenylic acids as byproducts.
GB1176562A 1961-03-27 1962-03-27 A process for the production of 5-guanylic acid Expired GB938322A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1003061 1961-03-27
JP97862 1962-01-18

Publications (1)

Publication Number Publication Date
GB938322A true GB938322A (en) 1963-10-02

Family

ID=26334108

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1176562A Expired GB938322A (en) 1961-03-27 1962-03-27 A process for the production of 5-guanylic acid

Country Status (2)

Country Link
CH (1) CH411905A (en)
GB (1) GB938322A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1570022B1 (en) * 1964-03-09 1972-02-03 Kyowa Hakko Kogyo Kk Process for the production of 5'-purine nucleotides by fermentation of microorganisms in an aqueous nutrient medium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1570022B1 (en) * 1964-03-09 1972-02-03 Kyowa Hakko Kogyo Kk Process for the production of 5'-purine nucleotides by fermentation of microorganisms in an aqueous nutrient medium

Also Published As

Publication number Publication date
CH411905A (en) 1966-04-30

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