GB936894A - Novel steroid compounds and processes for the preparation thereof - Google Patents

Novel steroid compounds and processes for the preparation thereof

Info

Publication number
GB936894A
GB936894A GB12180/63A GB1218063A GB936894A GB 936894 A GB936894 A GB 936894A GB 12180/63 A GB12180/63 A GB 12180/63A GB 1218063 A GB1218063 A GB 1218063A GB 936894 A GB936894 A GB 936894A
Authority
GB
United Kingdom
Prior art keywords
preparation
acyloxy
processes
epoxy
steroid compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12180/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR828241A external-priority patent/FR1269641A/en
Priority claimed from FR828240A external-priority patent/FR1363863A/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB936894A publication Critical patent/GB936894A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises the 17-acyloxy-9a , 10a -epoxy-19-nor-androst-4-en-3-ones of the formula: <FORM:0936894/IV(a)/1> wherein OAc represents an acyloxy radical, and a process for the preparation thereof in which a 3b -methyl-7-keto-8b -(g -keto-butyl)-8a ,9a -epoxy-3a , 4b - [31-acyloxy-(21,11) -cyclopentano]-decahydronaphthalene compound of the formula: <FORM:0936894/IV(a)/2> is cyclised by reaction with an alkali metal acylate, in the presence of the hydroxide of the same metal, so as to yield the corresponding 17b -acyloxy derivative of 9a ,10a -epoxy-19-nor-androst-4-en-3-one. Specification 914,734 also is referred to.
GB12180/63A 1960-05-25 1961-05-17 Novel steroid compounds and processes for the preparation thereof Expired GB936894A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR828241A FR1269641A (en) 1960-05-25 1960-05-25 New process for the preparation of aminosteroids
FR828240A FR1363863A (en) 1960-05-25 1960-05-25 Process for the preparation of aminosteroids

Publications (1)

Publication Number Publication Date
GB936894A true GB936894A (en) 1963-09-18

Family

ID=26186167

Family Applications (2)

Application Number Title Priority Date Filing Date
GB12180/63A Expired GB936894A (en) 1960-05-25 1961-05-17 Novel steroid compounds and processes for the preparation thereof
GB18012/61A Expired GB936893A (en) 1960-05-25 1961-05-17 New steroid compounds and processes for the preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB18012/61A Expired GB936893A (en) 1960-05-25 1961-05-17 New steroid compounds and processes for the preparation thereof

Country Status (5)

Country Link
BE (1) BE604204A (en)
CH (2) CH490354A (en)
GB (2) GB936894A (en)
NL (1) NL110320C (en)
SE (1) SE305651B (en)

Also Published As

Publication number Publication date
CH490354A (en) 1970-05-15
SE305651B (en) 1968-11-04
BE604204A (en) 1961-11-27
NL110320C (en) 1964-07-15
CH404655A (en) 1965-12-31
GB936893A (en) 1963-09-18

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