GB927218A - A method and apparatus for making pharmaceutical beads - Google Patents

A method and apparatus for making pharmaceutical beads

Info

Publication number
GB927218A
GB927218A GB256560A GB256560A GB927218A GB 927218 A GB927218 A GB 927218A GB 256560 A GB256560 A GB 256560A GB 256560 A GB256560 A GB 256560A GB 927218 A GB927218 A GB 927218A
Authority
GB
United Kingdom
Prior art keywords
sol
beads
immiscible liquid
pharmaceutical
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB256560A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARL ERNST FISHER
CHARLES HERBERT WILSON
Original Assignee
CARL ERNST FISHER
CHARLES HERBERT WILSON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARL ERNST FISHER, CHARLES HERBERT WILSON filed Critical CARL ERNST FISHER
Publication of GB927218A publication Critical patent/GB927218A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

927,218. Pharmaceutical beads and apparatus and methods for preparing the same. C. E. FISHER, and C. H. WILSON. Jan. 25, 1960 [Jan. 30, 1959], No. 2565/60. Class 81 (1). [Also in Group V] Substantially dry spherical pharmaceutical beads are made by directing preferably under pressure and through an orifice, a fine continuous stream of a composition comprising a sol of a congealable material e.g. gelatin, zein or carbowax and a pharmaceutical material, the temperature of said composition being above the congealing temperature of the sol, into a body of an immiscible liquid for said composition at a temperature below the congealing temperature of the sol, the body of the immiscible liquid moving transversely relative to the direction of movement of the stream of the composition and the depth and spread of the body of immiscible liquid being such that successive spherical beads are formed of substantially uniform diameter without interference of one bead with the other. An apparatus for making said beads comprises a reservoir 10 of congealable material containing said pharmaceutical material connected to a chamber 12. A plurality of orifices 14 are provided in chamber 12. Air under pressure in chamber 12 forces the sol through the orifices 14 into the immiscible liquid provided by a pump 16 from a supply 17 said liquid being directed over a trough 18 in a layer below the orifices, said layer being of a sufficient depth to prevent the beads formed from striking the trough. Heating coil 19 maintains the sol above its congealing temperature in reservoir 12. Cooling means 20 maintains the immiscible liquid below the congealing temperature of the sol. The beads formed range in size from 10-80 mesh U.S. standard and after formation are washed in a solvent e.g. naphtha or carbon tetrachloride and dried. The sol may also contain plasticizing agents e.g. sorbitol and substances reducing solubility e.g. for a gelatin sol, aldehydes such as formaldehyde, vanellin benzaldehyde or phenol. The beads may also be tanned. Specified pharmaceutical materials are D-amphetamine sulphate, Vitamin B12, Riboflavin, Thiamine hydrochloride, sulphaguanadine, D - amphetamine. Other constituents of the sol include isopropyl alcohol and flavouring agents. The spherical beads formed may be mixed with excipients e.g. lactose and magnesium stearate and compressed into tablets. The beads may also be coated with carbowax, shellac starch paste, glucose or acacia dried and compressed or may be enteric coated.
GB256560A 1959-01-30 1960-01-25 A method and apparatus for making pharmaceutical beads Expired GB927218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79015559A 1959-01-30 1959-01-30

Publications (1)

Publication Number Publication Date
GB927218A true GB927218A (en) 1963-05-29

Family

ID=25149796

Family Applications (2)

Application Number Title Priority Date Filing Date
GB256560A Expired GB927218A (en) 1959-01-30 1960-01-25 A method and apparatus for making pharmaceutical beads
GB1764562A Expired GB966274A (en) 1959-01-30 1962-05-08 A method and apparatus for making pharmaceutical beads

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1764562A Expired GB966274A (en) 1959-01-30 1962-05-08 A method and apparatus for making pharmaceutical beads

Country Status (2)

Country Link
DE (1) DE1248863B (en)
GB (2) GB927218A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081913A1 (en) * 1981-12-11 1983-06-22 JOHN WYETH & BROTHER LIMITED Process and apparatus for freezing a liquid medium
US4609542A (en) * 1978-12-22 1986-09-02 Elan Corporation, P.L.C. New pharmaceutical forms for administration of medicaments by oral route, with programmed release
WO1993013757A1 (en) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609542A (en) * 1978-12-22 1986-09-02 Elan Corporation, P.L.C. New pharmaceutical forms for administration of medicaments by oral route, with programmed release
EP0081913A1 (en) * 1981-12-11 1983-06-22 JOHN WYETH & BROTHER LIMITED Process and apparatus for freezing a liquid medium
US4470202A (en) * 1981-12-11 1984-09-11 John Weyeth & Brother Limited Process and apparatus for freezing a liquid medium
WO1993013757A1 (en) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies

Also Published As

Publication number Publication date
DE1248863B (en)
GB966274A (en) 1964-08-06

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