GB924257A - Cyclopentane derivatives and a process for the manufacture thereof - Google Patents

Cyclopentane derivatives and a process for the manufacture thereof

Info

Publication number
GB924257A
GB924257A GB25737/62A GB2573762A GB924257A GB 924257 A GB924257 A GB 924257A GB 25737/62 A GB25737/62 A GB 25737/62A GB 2573762 A GB2573762 A GB 2573762A GB 924257 A GB924257 A GB 924257A
Authority
GB
United Kingdom
Prior art keywords
cyclopentane
trimethyl
hydroxy
acid
camphonanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25737/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Priority to GB25737/62A priority Critical patent/GB924257A/en
Publication of GB924257A publication Critical patent/GB924257A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises 1-acetyl-1.2.2-trimethyl-cyclopentane and the corresponding compounds having in the 3- or 4-position a hydroxyl group. These compounds may be obtained by reacting 1-carboxy-1.2.2-trimethyl-cyclopentane or a 3- or 4-(hydroxy or oxo)-derivative thereof with methyl-lithium (after reduction of a ring-keto group to a hydroxyl group in cases where it is desired to prepare a hydroxy compound using a ketonic starting material). In an example, camphonanic acid in ether is added dropwise to an ethereal solution of methyl lithium and the mixture is maintained under reflux for several hours and cooled. Isolation of the neutral product gives 1-acetyl-1.2.2-trimethyl-cyclopentane. In another example, 3-keto-camphonanic acid is treated with potassium borohydride, caustic soda, and water, heated and then cooled and treated with sulphuric acid to give 3-hydroxy-camphonanic acid. This hydroxy compound is treated with methyl lithium and refluxed to give 1-acetyl- 3-hydroxy- 1.2.2.-trimethyl cyclopentane. Specification 924,256 also is referred to.
GB25737/62A 1959-11-25 1959-11-25 Cyclopentane derivatives and a process for the manufacture thereof Expired GB924257A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB25737/62A GB924257A (en) 1959-11-25 1959-11-25 Cyclopentane derivatives and a process for the manufacture thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB25737/62A GB924257A (en) 1959-11-25 1959-11-25 Cyclopentane derivatives and a process for the manufacture thereof

Publications (1)

Publication Number Publication Date
GB924257A true GB924257A (en) 1963-04-24

Family

ID=10232463

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25737/62A Expired GB924257A (en) 1959-11-25 1959-11-25 Cyclopentane derivatives and a process for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB924257A (en)

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