GB911428A - Steroids - Google Patents
SteroidsInfo
- Publication number
- GB911428A GB911428A GB1556860A GB1556860A GB911428A GB 911428 A GB911428 A GB 911428A GB 1556860 A GB1556860 A GB 1556860A GB 1556860 A GB1556860 A GB 1556860A GB 911428 A GB911428 A GB 911428A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- aliphatic
- enol
- above formula
- nortestosterones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 3-enol ethers of 19-nortestosterones having the general formula <FORM:0911428/IV (b)/1> wherein R represents a hydrocarbon radical containing from 1 to 12 carbon atoms, R1 represents hydrogen or the acyl radical derived from an alkanoic acid containing up to 3 carbon atoms, and R2 represents an alkyl or alkynyl radical containing up to 4 carbon atoms, and the preparation of the 3-aliphatic enol ethers of the above formula in which the aliphatic group contains up to 5 carbon atoms by reacting the corresponding D 4-3-ketone with the required aliphatic orthoformate, and the preparation of 3-aliphatic, cycloaliphatic and arylaliphatic enol ethers of the above formula (other than the 3-enol ethyl ether) by reacting the 3-enol ethyl ether of the above formula with an excess of the required alcohol in solution in an organic solvent in the presence of a catalytic amount of an acid catalyst. Pharmaceutical compositions suitable for the treatment of dysmenorrhea, amenorrhea, endometriosis, abortion and similar disturbances comprise 19-nortestosterones of the above general formula in an oily solution.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV16478A DE1119264B (en) | 1959-05-04 | 1959-05-04 | Process for the preparation of enola ethers of í¸-3-ketosteroids of the androstane and pregnane series |
| IT381360 | 1960-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB911428A true GB911428A (en) | 1962-11-28 |
Family
ID=26001360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1556860A Expired GB911428A (en) | 1959-05-04 | 1960-05-03 | Steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB911428A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272445A (en) * | 1977-05-25 | 1981-06-09 | Beecham Group Limited | Process for preparing active compounds |
-
1960
- 1960-05-03 GB GB1556860A patent/GB911428A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272445A (en) * | 1977-05-25 | 1981-06-09 | Beecham Group Limited | Process for preparing active compounds |
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