GB879441A - Improved injectable iron preparations - Google Patents
Improved injectable iron preparationsInfo
- Publication number
- GB879441A GB879441A GB1769559A GB1769559A GB879441A GB 879441 A GB879441 A GB 879441A GB 1769559 A GB1769559 A GB 1769559A GB 1769559 A GB1769559 A GB 1769559A GB 879441 A GB879441 A GB 879441A
- Authority
- GB
- United Kingdom
- Prior art keywords
- iron
- polysaccharide
- added
- dialysed
- ferric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0036—Galactans; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An injectable iron preparation is obtained by the reaction of an iron salt such as ferric chloride or ferric nitrate or of ferric oxychloride or of dialysed iron with a synthetic polysaccharide such as polyglucose or polygalactose in an alkaline medium. The ratio of the weight of the polysaccharde to the weight of iron is preferably from 10-20 : 1. The polysaccharide may be obtained by heating glucose or galactose with an acid catalyst until the resulting polysaccharide possesses only 5% and 1% respectively of the reducing value of the original sugar. It is then dissolved in water and the iron salt or dialysed iron added and then sufficient caustic soda solution added to produce a pH of about 11, and then the mixture heated to 100 DEG C. for about two hours. It is then cooled and methanol, ethanol, or acetone added and the precipitate removed. The injectable solution may contain 5- 1/4 % of iron.ALSO:An injectable iron preparation is obtained by the reaction of an iron salt such as ferric chloride or ferric nitrate or of ferric oxychloride or of dialysed iron with a synthetic polysaccharide such as polyglucose or polygalactose in an alkaline medium. The ratio of the weight of the polysaccharide to the weight of iron is preferably from 10 to 20 : 1. The polysaccharide may be obtained by heating glucose or galactose with an acid catalyst until the resulting polysaccharide possesses only 5% and 1% respectively of the reducing value of the original sugar. It is then dissolved in water and the iron salt or dialysed iron added and then sufficient caustic soda solution added to produce a pH of about 11, and then the mixture heated to 100 DEG C. for about two hours. It is then cooled and methanol ethanol or acetone added and the precipitate removed. The injectable solution may contain 5-7 1/4 % of iron.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1769559A GB879441A (en) | 1959-05-25 | 1959-05-25 | Improved injectable iron preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1769559A GB879441A (en) | 1959-05-25 | 1959-05-25 | Improved injectable iron preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB879441A true GB879441A (en) | 1961-10-11 |
Family
ID=10099601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1769559A Expired GB879441A (en) | 1959-05-25 | 1959-05-25 | Improved injectable iron preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB879441A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693211B2 (en) | 2002-05-15 | 2004-02-17 | Geneva Pharmaceuticals, Inc. | Chemical process |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| CN103864950A (en) * | 2014-03-21 | 2014-06-18 | 张忠山 | Preparation method and application of low-molecular porphyra haitanensis polyferose compound |
| CN105344313A (en) * | 2015-11-27 | 2016-02-24 | 内蒙古民族大学 | Dissolved acetylene purifying agent |
| US9376505B2 (en) | 2002-10-23 | 2016-06-28 | Vifor (International) Ag. | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
-
1959
- 1959-05-25 GB GB1769559A patent/GB879441A/en not_active Expired
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693211B2 (en) | 2002-05-15 | 2004-02-17 | Geneva Pharmaceuticals, Inc. | Chemical process |
| US10519252B2 (en) | 2002-10-23 | 2019-12-31 | Vifor (International) Ag. | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11590097B2 (en) | 2002-10-23 | 2023-02-28 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US9376505B2 (en) | 2002-10-23 | 2016-06-28 | Vifor (International) Ag. | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11291645B2 (en) | 2002-10-23 | 2022-04-05 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US8691776B2 (en) | 2003-05-30 | 2014-04-08 | Chromaceutical Advanced Technologies,Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US11364260B2 (en) | 2006-01-06 | 2022-06-21 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11406656B2 (en) | 2006-01-06 | 2022-08-09 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11433091B2 (en) | 2006-01-06 | 2022-09-06 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11478502B2 (en) | 2006-01-06 | 2022-10-25 | American Regent, Inc. | Methods and compositions for administration of iron |
| CN103864950B (en) * | 2014-03-21 | 2016-08-17 | 湖州师范学院 | A kind of preparation method and applications of low molecule Porphyra haitanensis polysaccharide iron complexes |
| CN103864950A (en) * | 2014-03-21 | 2014-06-18 | 张忠山 | Preparation method and application of low-molecular porphyra haitanensis polyferose compound |
| CN105344313B (en) * | 2015-11-27 | 2018-01-16 | 内蒙古民族大学 | A kind of dissolved acetylene scarvenger |
| CN105344313A (en) * | 2015-11-27 | 2016-02-24 | 内蒙古民族大学 | Dissolved acetylene purifying agent |
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