GB867166A - A process for the manufacture of alpha tocopherol and its acetate - Google Patents

A process for the manufacture of alpha tocopherol and its acetate

Info

Publication number
GB867166A
GB867166A GB35278/59A GB3527859A GB867166A GB 867166 A GB867166 A GB 867166A GB 35278/59 A GB35278/59 A GB 35278/59A GB 3527859 A GB3527859 A GB 3527859A GB 867166 A GB867166 A GB 867166A
Authority
GB
United Kingdom
Prior art keywords
acetate
manufacture
alpha tocopherol
tocopherol
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35278/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB867166A publication Critical patent/GB867166A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Alpha-tocopherol is synthesised by condensing trimethylhydroquinone with isophytol in presence of a BF3 condensing agent (which may be a BF3 di-lower alkyl, e.g. Et, etherate); optionally the product is converted to the acetate using acetic anhydride. An example is given.
GB35278/59A 1958-10-24 1959-10-19 A process for the manufacture of alpha tocopherol and its acetate Expired GB867166A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US867166XA 1958-10-24 1958-10-24

Publications (1)

Publication Number Publication Date
GB867166A true GB867166A (en) 1961-05-03

Family

ID=22200406

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35278/59A Expired GB867166A (en) 1958-10-24 1959-10-19 A process for the manufacture of alpha tocopherol and its acetate

Country Status (1)

Country Link
GB (1) GB867166A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858813B2 (en) 2004-08-19 2010-12-28 Dsm Ip Assets B.V. Process for the rectification of mixtures of high-boiling air-and/or temperature-sensitive useful products
US8183396B2 (en) * 2004-08-19 2012-05-22 Dsm Ip Assets B.V. Process for the working-up of a vitamin E- and vitamin E-acetate- containing mixture or products stream

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858813B2 (en) 2004-08-19 2010-12-28 Dsm Ip Assets B.V. Process for the rectification of mixtures of high-boiling air-and/or temperature-sensitive useful products
US8183396B2 (en) * 2004-08-19 2012-05-22 Dsm Ip Assets B.V. Process for the working-up of a vitamin E- and vitamin E-acetate- containing mixture or products stream
US8414850B2 (en) 2004-08-19 2013-04-09 Dsm Ip Assets B.V. Process for the working-up of a vitamin E- and vitamin E-acetate-containing mixture or product stream
US8420838B2 (en) 2004-08-19 2013-04-16 Dsm Ip Assets B.V. Process for the rectification of mixtures of high-boiling air- and/or temperature-sensitive useful products
US8747621B2 (en) 2004-08-19 2014-06-10 Dsm Ip Assets B.V. Process for the rectification of mixtures of high-boiling air- and/or temperature-sensitive useful products

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