GB861784A - Improved aerobic fermentation process - Google Patents

Improved aerobic fermentation process

Info

Publication number
GB861784A
GB861784A GB1061/58A GB106158A GB861784A GB 861784 A GB861784 A GB 861784A GB 1061/58 A GB1061/58 A GB 1061/58A GB 106158 A GB106158 A GB 106158A GB 861784 A GB861784 A GB 861784A
Authority
GB
United Kingdom
Prior art keywords
added
hydrogen peroxide
fermentation
nutrient medium
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1061/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour and Co
Original Assignee
Armour and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour and Co filed Critical Armour and Co
Publication of GB861784A publication Critical patent/GB861784A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/48—Tricarboxylic acids, e.g. citric acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/54—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being bound directly to a nitrogen atom of two or more radicals, e.g. streptomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

In an aerobic fermentation process in which a culture of a micro-organism is added to a nutrient medium, the nutrient medium is first sterilized by the addition of hydrogen peroxide, catalase is then added to the medium and finally a culture of the micro-organism and the fermentation proceeds under conditions suitable for the growth of the micro-organism, additional hydrogen peroxide being added continuously throughout the fermentation to provide oxygen for the micro-organism. Further nutrient medium sterilized with hydrogen peroxide may be added to the broth as fermentation proceeds. The process may be employed in the production of (a) vitamins such as B12 and riboflavin; (b) antibiotics such as penicillin, streptomycin, tetracyclines e.g. chlortetracycline and oxytetracycline, and bacitracin; (c) citric acid; and (d) oxygenation of steroids, particularly p 11-dehydrocorticosterone to cortisone and progesterone to 11-hydroxyprogesterone.ALSO:In an aerobic fermentation process in which a culture of a microorganism is added to a nutrient medium, the nutrient medium is first sterilized by the addition of hydrogen peroxide, catalose is then added to the medium and finally a culture of the microorganism and the fermentation proceeds under conditions suitable for the growth of the microorganism, additional hydrogen peroxide being added continuously throughout the fermentation to provide oxygen for the microorganism. Further nutrient medium sterilized with hydrogen peroxide may be added to the broth as fermentation proceeds. The process may be employed for the fermentation of organisms for the production of yeast, vitamins such as B12 and riboflavin, citric acid and antibiotics such as penicillin, streptomycin, tetracyclines, e.g. chlortetracyclic and oxytetracycline and bacitracins, and for the oxygenation of steroids. In the production of yeast, using Saccharomyces cereviscal or Torula utilis hydrogen peroxide is added initially in the amount of 0.2 to 1% and thereafter at the rate of 0.66 grams. per litre per hour.
GB1061/58A 1957-01-11 1958-01-10 Improved aerobic fermentation process Expired GB861784A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US861784XA 1957-01-11 1957-01-11

Publications (1)

Publication Number Publication Date
GB861784A true GB861784A (en) 1961-02-22

Family

ID=22196803

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1061/58A Expired GB861784A (en) 1957-01-11 1958-01-10 Improved aerobic fermentation process

Country Status (1)

Country Link
GB (1) GB861784A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2800917A1 (en) * 1977-01-10 1978-07-13 Interox METHOD OF BREEDING MICRO-ORGANISMS
WO2023166156A1 (en) * 2022-03-04 2023-09-07 Chr. Hansen A/S Method for preparing cultures of lactic acid bacteria, products and culture media therefore

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2800917A1 (en) * 1977-01-10 1978-07-13 Interox METHOD OF BREEDING MICRO-ORGANISMS
FR2376897A1 (en) * 1977-01-10 1978-08-04 Interox MICROORGANISMS CULTURE PROCESS
US4326035A (en) 1977-01-10 1982-04-20 Interox Process for the culture of aerobic microorganisms
WO2023166156A1 (en) * 2022-03-04 2023-09-07 Chr. Hansen A/S Method for preparing cultures of lactic acid bacteria, products and culture media therefore

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