GB859609A - Improvements in or relating to lyophilized protein hydrolysates - Google Patents

Improvements in or relating to lyophilized protein hydrolysates

Info

Publication number
GB859609A
GB859609A GB2073458A GB2073458A GB859609A GB 859609 A GB859609 A GB 859609A GB 2073458 A GB2073458 A GB 2073458A GB 2073458 A GB2073458 A GB 2073458A GB 859609 A GB859609 A GB 859609A
Authority
GB
United Kingdom
Prior art keywords
gelatin
hydrolysate
aqueous solution
lyophiliser
protein hydrolysate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2073458A
Inventor
Charles William Frank Damaskus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour and Co
Original Assignee
Armour and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour and Co filed Critical Armour and Co
Priority to GB2073458A priority Critical patent/GB859609A/en
Publication of GB859609A publication Critical patent/GB859609A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Non-gelatinous protein hydrolysate suitable for parenteral use is lyophilized in aqueous solution containing, in addition to the protein hydrolysate, a gelatin hydrolysate having a gel point of 15 to 20 DEG C. in 26 to 35% aqueous solution and being present in a ratio of 1 to 2 parts of gelatin hydrolysate to 9 parts of the non-gelatinous protein hydrolysate; it is stated that the foaming problem normally encountered does not become apparent to any appreciable extent when the partially hydrolysed gelatin is included. The gelatin hydrolysate may be made by hydrolysing an aqueous solution of gelatin for three hours at approximately 250 DEG F. and 15 lbs. per sq. inch pressure. According to an example, to 1,470 ml. of 23% casein hydrolysate in which 69% of the total nitrogen was in the form of a -amino nitrogen, there was added 188 ml. of hydrolysed gelatin prepared as described above and containing 32% solids. Vitamins &c., dextrose and sodium ethyl mercurithiosalicylate were added and the total volume of the solution was brought up to 3,08 litres with warm pyrogenfree distilled water. After filtering, 77 ml. portions of the solution filled into 250 ml. brown-glass bottles were frozen at -60 DEG F. and then placed in a lyophiliser, the pressure being decreased to 50-150 microms. The bottles were finally removed from the lyophiliser and aseptically stoppered. The product, which contained less than 5% of moisture, reconstituted readily with pyrogen-free distilled water. Other examples are concerned with lyophilising bovine plasma and fibrin hydrolysates.
GB2073458A 1958-06-27 1958-06-27 Improvements in or relating to lyophilized protein hydrolysates Expired GB859609A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2073458A GB859609A (en) 1958-06-27 1958-06-27 Improvements in or relating to lyophilized protein hydrolysates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2073458A GB859609A (en) 1958-06-27 1958-06-27 Improvements in or relating to lyophilized protein hydrolysates

Publications (1)

Publication Number Publication Date
GB859609A true GB859609A (en) 1961-01-25

Family

ID=10150764

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2073458A Expired GB859609A (en) 1958-06-27 1958-06-27 Improvements in or relating to lyophilized protein hydrolysates

Country Status (1)

Country Link
GB (1) GB859609A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017180648A1 (en) * 2016-04-11 2017-10-19 Cook Biotech Incorporated Fibrin and/or dialdehyde starch hydrolysate materials, and preparation and use thereof
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017180648A1 (en) * 2016-04-11 2017-10-19 Cook Biotech Incorporated Fibrin and/or dialdehyde starch hydrolysate materials, and preparation and use thereof
US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11609042B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
US11609043B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use
US11740019B2 (en) 2019-03-14 2023-08-29 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11747082B2 (en) 2019-03-14 2023-09-05 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
US11815311B2 (en) 2019-03-14 2023-11-14 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use
US11994343B2 (en) 2019-03-14 2024-05-28 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use

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