GB859245A - N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of same - Google Patents
N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of sameInfo
- Publication number
- GB859245A GB859245A GB10167/59A GB1016759A GB859245A GB 859245 A GB859245 A GB 859245A GB 10167/59 A GB10167/59 A GB 10167/59A GB 1016759 A GB1016759 A GB 1016759A GB 859245 A GB859245 A GB 859245A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glycosides
- fluoro
- salts
- cytosine
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
The invention comprises N1-glycosides of 5-fluorocytosine and medicinally acceptable acid addition salts thereof; and the preparation thereof by reacting an O-acyl ester of an N1-glycoside of 5-fluoro-uracil with a thiating agent in a basic medium, treating the O-acyl ester of an N1-glycaside of 4-thio-5-fluoruracil so formed with excess ammonia and, if desired, converting the product into an acid addition salt. Specification 824,614 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US859245XA | 1958-04-17 | 1958-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB859245A true GB859245A (en) | 1961-01-18 |
Family
ID=22194883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB10167/59A Expired GB859245A (en) | 1958-04-17 | 1959-03-24 | N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of same |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB859245A (en) |
-
1959
- 1959-03-24 GB GB10167/59A patent/GB859245A/en not_active Expired
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