GB852735A - Manufacture of 1-aminoindanes - Google Patents

Manufacture of 1-aminoindanes

Info

Publication number
GB852735A
GB852735A GB10798/57A GB1079857A GB852735A GB 852735 A GB852735 A GB 852735A GB 10798/57 A GB10798/57 A GB 10798/57A GB 1079857 A GB1079857 A GB 1079857A GB 852735 A GB852735 A GB 852735A
Authority
GB
United Kingdom
Prior art keywords
prepared
oxime
alkoxyindanone
substituted
indanone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10798/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB852735A publication Critical patent/GB852735A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises 1-aminoindanes not further substituted in the 5-membered ring but containing in the benzene ring (preferably in the 5-position) an alkoxy group of more than 2 carbon atoms, and their acid addition salts, and the preparation thereof by catalytic hydrogenation of the oxime or an oxime ether of a correspondingly substituted indanone-1, in an organic solvent. The products have a dilatation effect on the coronary blood vessels. 5-Alkoxyindanone-1 oximes are prepared by the action of hydroxylamine hydrochloride on 5-alkoxyindanones-1. 5-Alkoxyindanone-1-oxime ethers are prepared by dialkylation of 5-hydroxyindanone-1-oxime. 5-Hydroxy-, 5-butoxy- and 5-hexyloxy-indanone-1 are prepared by cyclizing the corresponding m-substituted hydrocinnamic acids, e.g. by means of polyphosphoric acid. The 5-alkoxy compounds may also be prepared by etherifying the 5- hydroxy compound.
GB10798/57A 1956-04-13 1957-04-02 Manufacture of 1-aminoindanes Expired GB852735A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE852735X 1956-04-13

Publications (1)

Publication Number Publication Date
GB852735A true GB852735A (en) 1960-11-02

Family

ID=6785608

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10798/57A Expired GB852735A (en) 1956-04-13 1957-04-02 Manufacture of 1-aminoindanes

Country Status (1)

Country Link
GB (1) GB852735A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0738149A1 (en) * 1994-01-10 1996-10-23 Teva Pharmaceutical Industries, Ltd. 1-aminoindan derivatives and compositions thereof
US5639913A (en) * 1994-01-10 1997-06-17 Teva Pharmaceutical Industries, Ltd. Method for preparing optically active 1-aminoindan derivatives
US6462222B1 (en) 1996-12-18 2002-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Aminoindan derivatives
US6492426B1 (en) 1999-10-27 2002-12-10 Teva Pharmaceutical Industries, Ltd. Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
US7625946B2 (en) 2006-02-24 2009-12-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Propargylated aminoindans, processes for preparation, and uses thereof
US8420696B2 (en) 2005-12-09 2013-04-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of low-dose ladostigil for neuroprotection

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528685B2 (en) 1994-01-10 2003-03-04 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5639913A (en) * 1994-01-10 1997-06-17 Teva Pharmaceutical Industries, Ltd. Method for preparing optically active 1-aminoindan derivatives
EP0738149A4 (en) * 1994-01-10 1999-10-27 Teva Pharma 1-aminoindan derivatives and compositions thereof
US6271263B1 (en) 1994-01-10 2001-08-07 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
EP0738149A1 (en) * 1994-01-10 1996-10-23 Teva Pharmaceutical Industries, Ltd. 1-aminoindan derivatives and compositions thereof
US6462222B1 (en) 1996-12-18 2002-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Aminoindan derivatives
US6538025B2 (en) 1996-12-18 2003-03-25 Teva Pharmaceutical Industries, Ltd. Aminoindan derivatives
USRE39616E1 (en) 1996-12-18 2007-05-08 Teva Pharmaceutical Industries, Ltd. Aminoindan derivatives
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
US6492426B1 (en) 1999-10-27 2002-12-10 Teva Pharmaceutical Industries, Ltd. Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder
US8420696B2 (en) 2005-12-09 2013-04-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of low-dose ladostigil for neuroprotection
US7625946B2 (en) 2006-02-24 2009-12-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Propargylated aminoindans, processes for preparation, and uses thereof
US8609719B2 (en) 2006-02-24 2013-12-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Propargylated aminoindans, processes for preparation, and uses thereof

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