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Expired
Application number
GB20719/57A
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Laboratoires Francais de Chimiotherapie SA
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Laboratoires Francais de Chimiotherapie SA
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Publication of GB834692ApublicationCriticalpatent/GB834692A/en
C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Health & Medical Sciences
(AREA)
General Health & Medical Sciences
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
The 17-acetate of cis-testosterone is prepared by reacting an alkali metal acetate with the 17-tosylate of trans-testosterone in the presence of a N-alkyl-disubstituted aliphatic carboxylic acid amide containing a total of up to 8 carbon atoms. The above process may be modified in that the 17-acetate of cis-testosterone is saponified to form cis-testosterone. Suitable amides are dimethylformamide and dimethylacetamide. The reaction may be carried out at elevated temperatures, e.g. at the boiling point of the reaction mixture. Potassium or sodium acetate may be used as the alkali metal acetate. One detailed example is given. 17-Tosylate of trans-testosterone is prepared by reacting testosterone and tosyl chloride in the presence of pyridine. Specification 822,205 is referred to.
GB20719/57A1956-07-181957-07-01Process for the preparation of bis-testosterone and the 17-acetate thereof
ExpiredGB834692A
(en)
A procedure for the preparation of antiparasitaries based on N-alkyl-amidos of the acids or, O-dialquilditiofosforilacºticos (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of new esters 1-alkyl-4-piperidilic O-substitute benzoic acids (Machine-translation by Google Translate, not legally binding)