GB831124A - Purification of collagen - Google Patents
Purification of collagenInfo
- Publication number
- GB831124A GB831124A GB13406/56A GB1340656A GB831124A GB 831124 A GB831124 A GB 831124A GB 13406/56 A GB13406/56 A GB 13406/56A GB 1340656 A GB1340656 A GB 1340656A GB 831124 A GB831124 A GB 831124A
- Authority
- GB
- United Kingdom
- Prior art keywords
- collagen
- dispersion
- collagenous
- acid
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09H—PREPARATION OF GLUE OR GELATINE
- C09H3/00—Isolation of glue or gelatine from raw materials, e.g. by extracting, by heating
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
A dispersion of collagen in a suitable dispersion medium is prepared by a process in which as an initial step, finely divided collagen is purified by removal of non-collagenous material by p enzymatic digestion. Extraneous matter may be physically removed from mammalian collagenous tissue, e.g. fresh tendons, hides, and the tissue then treated with a solution of an enzyme capable of acting on and dissolving non-collagenous substances, for a period of at least 10 hours at between 5 DEG and 45 DEG C. and pH 5 to 9, prior to dispersing the separated material in a dispersive medium, e.g. aqueous acid such as acetic or malonic acid. Collagen may be obtained by precipitation from the dispersion by addition thereto of an acid neutralizing agent, e.g. ammonia, or collagen strands may be formed by extrusion of the dispersion into an acid neutralizing bath, e.g. acetone containing ammonia. Specified enzymes are malt diastase, pancreatin, and microorganisms of the B. subtilis group.ALSO:Strands of collagen are formed by extrusion of a dispersion of collagen into an acid-neutralizing bath, e.g. acetone containing ammonia, the dispersion having been formed by a process in which, as an initial step, finely divided collagen is purified by removal of non-collagenous material by enzymatic digestion. The dispersion may be formed by physically removing extraneous matter, e.g. muscle and fat, from mammalian collagenous tissue, e.g. fresh tendons or hide, and treating the tissue with a solution of an enzyme capable of acting on and dissolving non-collagenous substances for a period of at least 10 hours at between 5 DEG and 45 DEG C. and pH 5 to 9, prior to dispersing the separated material in a dispersive medium, e.g. an aqueous acid such as acetic or malonic acid. Specified enzymes are malt diastase, pancreatin, and micro-organisms of the B. subtilis group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US831124XA | 1955-05-18 | 1955-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB831124A true GB831124A (en) | 1960-03-23 |
Family
ID=22176255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13406/56A Expired GB831124A (en) | 1955-05-18 | 1956-05-01 | Purification of collagen |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB831124A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138030A (en) * | 1989-10-10 | 1992-08-11 | Pachence James M | Process for extracting type I collagen form an avian source, and applications therefor |
| WO1995025550A1 (en) * | 1994-03-22 | 1995-09-28 | Organogenesis Inc. | Biocompatible prosthetic devices |
| US6361551B1 (en) | 1998-12-11 | 2002-03-26 | C. R. Bard, Inc. | Collagen hemostatic fibers |
| US6454787B1 (en) | 1998-12-11 | 2002-09-24 | C. R. Bard, Inc. | Collagen hemostatic foam |
| CN101921547A (en) * | 2010-08-20 | 2010-12-22 | 蚌埠丰原明胶有限公司 | Method for pretreating gelatin by liming |
| WO2011022794A1 (en) * | 2009-08-24 | 2011-03-03 | Novaprom Food Ingredients Ltda | Process to extract the collagen protein from bovine hide |
-
1956
- 1956-05-01 GB GB13406/56A patent/GB831124A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138030A (en) * | 1989-10-10 | 1992-08-11 | Pachence James M | Process for extracting type I collagen form an avian source, and applications therefor |
| WO1995025550A1 (en) * | 1994-03-22 | 1995-09-28 | Organogenesis Inc. | Biocompatible prosthetic devices |
| US6361551B1 (en) | 1998-12-11 | 2002-03-26 | C. R. Bard, Inc. | Collagen hemostatic fibers |
| US6454787B1 (en) | 1998-12-11 | 2002-09-24 | C. R. Bard, Inc. | Collagen hemostatic foam |
| WO2011022794A1 (en) * | 2009-08-24 | 2011-03-03 | Novaprom Food Ingredients Ltda | Process to extract the collagen protein from bovine hide |
| CN101921547A (en) * | 2010-08-20 | 2010-12-22 | 蚌埠丰原明胶有限公司 | Method for pretreating gelatin by liming |
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