GB823242A - Therapeutic compositions containing choline salts of dialkyl xanthines - Google Patents
Therapeutic compositions containing choline salts of dialkyl xanthinesInfo
- Publication number
- GB823242A GB823242A GB1688256A GB1688256A GB823242A GB 823242 A GB823242 A GB 823242A GB 1688256 A GB1688256 A GB 1688256A GB 1688256 A GB1688256 A GB 1688256A GB 823242 A GB823242 A GB 823242A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dialkylxanthine
- preparations
- compositions containing
- therapeutic compositions
- choline salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pharmaceutical preparations comprise one or more chloline salts of the general formula <FORM:0823242/VI/1> where X is the residue of a dialkylxanthine or a dialkylxanthine substituted in the 8 position by chlorine, bromine or a nitro-group or other non-acidic substituent, the alkyl groups of said dialkylxanthines containing one or two carbon atoms, together with a non-toxic pharmaceutical carrier, the preparation being stabilized against the decomposing action of water and/or carbon dioxide. The preferred choline salt is choline theophyllinate and other medicinal agents such as ephedrine, neohetramine hydrochloride, pentobarbital, racephedrine and reserpine may be included in the preparations. Solid preparations such as tablets are conveniently stabilized by reducing the water content to not more than 1.5% and preferably less than 1% by weight. In the case of suppositories, stabilization may be secured by incorporating polyvinyl pyrrolidone and/or a buffer such as tricalcium phosphate. Liquid forms for oral or parenteral administration are preferably buffered to pH 8-9.5, advantageously 8.5-9, by buffers such as citric acid and/or sodium citrate and may contain preservatives such as the methyl, ethyl, propyl or isopropyl esters of p-hydroxybenzoic acid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1688256A GB823242A (en) | 1956-05-31 | 1956-05-31 | Therapeutic compositions containing choline salts of dialkyl xanthines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1688256A GB823242A (en) | 1956-05-31 | 1956-05-31 | Therapeutic compositions containing choline salts of dialkyl xanthines |
Publications (1)
Publication Number | Publication Date |
---|---|
GB823242A true GB823242A (en) | 1959-11-11 |
Family
ID=10085375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1688256A Expired GB823242A (en) | 1956-05-31 | 1956-05-31 | Therapeutic compositions containing choline salts of dialkyl xanthines |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB823242A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0173240A2 (en) * | 1984-08-29 | 1986-03-05 | Asche Aktiengesellschaft | Injectable solution |
EP2522682A1 (en) | 2005-03-15 | 2012-11-14 | Polyplastics Co., Ltd. | Unstable terminal group decomposer, and stabilized polyacetal resin, manufacturing method, composition and molded article using the same |
-
1956
- 1956-05-31 GB GB1688256A patent/GB823242A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0173240A2 (en) * | 1984-08-29 | 1986-03-05 | Asche Aktiengesellschaft | Injectable solution |
EP0173240A3 (en) * | 1984-08-29 | 1987-06-24 | Asche Aktiengesellschaft | Injectable solution |
EP2522682A1 (en) | 2005-03-15 | 2012-11-14 | Polyplastics Co., Ltd. | Unstable terminal group decomposer, and stabilized polyacetal resin, manufacturing method, composition and molded article using the same |
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