Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5447/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SAfiledCriticalLaboratoires Francais de Chimiotherapie SA
Publication of GB822953ApublicationCriticalpatent/GB822953A/en
C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
Landscapes
Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Health & Medical Sciences
(AREA)
General Health & Medical Sciences
(AREA)
Steroid Compounds
(AREA)
Abstract
The invention comprises 3a -hemi-succinoyl-oxy - 11 - hydroxy - 12 - keto - D 9,11 - cholenic acid and physiologically acceptable salts thereof, and the preparation thereof by treating 3a -11-dihydroxy - 12 - keto - D 9,11 - cholenic acid dissolved in a solvent with a succinic anhydride in the presence of a condensation agent which may be a tertiary organic base such as pyridine. The salts may be derived from organic or mineral bases, the disodium salt being particularly referred to. 3a ,11 - Dihydroxy - 12 - keto - D 9,11 - cholenic acid is prepared by the hydrolysis of any suitable functional derivative thereof, e.g. methyl 3a - acetoxy - 11,12 - diketo - cholonate, 3a - formyloxy - 11,12 - diketo - cholanic acid or 3a - hemi - succinyloxy - 11,12 - diketo-cholonic acid. Specification 810,009 is referred to.ALSO:A therapeutic composition in the form of a capsule, granule, pastille or lozenge contains as the active ingredient a physiologically acceptable salt of 3a -hemi-succinyloxy-11-hydroxy - 12 - keto - D 9,11 - cholenic acid. The salt may be derived from an organic or inorganic base, the disodium salt being particularly referred to.
GB5447/57A1956-02-291957-02-18New derivative of dihydroxyketocholenic acid and process for its production
ExpiredGB822953A
(en)
Organic acid addition salts of alkamine esters of unsubstituted aminosalicylic acids and of alkamine esters of aminosalicylic acids substituted at the nitrogen atom and a process for their production
Procedure for the preparation of n (dietillaminoetil) - 2 - metoxi - 5 - metilsulfonil - benzamida. (Machine-translation by Google Translate, not legally binding)