GB822953A - New derivative of dihydroxyketocholenic acid and process for its production - Google Patents
New derivative of dihydroxyketocholenic acid and process for its productionInfo
- Publication number
- GB822953A GB822953A GB5447/57A GB544757A GB822953A GB 822953 A GB822953 A GB 822953A GB 5447/57 A GB5447/57 A GB 5447/57A GB 544757 A GB544757 A GB 544757A GB 822953 A GB822953 A GB 822953A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- keto
- diketo
- hemi
- cholenic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 3a -hemi-succinoyl-oxy - 11 - hydroxy - 12 - keto - D 9,11 - cholenic acid and physiologically acceptable salts thereof, and the preparation thereof by treating 3a -11-dihydroxy - 12 - keto - D 9,11 - cholenic acid dissolved in a solvent with a succinic anhydride in the presence of a condensation agent which may be a tertiary organic base such as pyridine. The salts may be derived from organic or mineral bases, the disodium salt being particularly referred to. 3a ,11 - Dihydroxy - 12 - keto - D 9,11 - cholenic acid is prepared by the hydrolysis of any suitable functional derivative thereof, e.g. methyl 3a - acetoxy - 11,12 - diketo - cholonate, 3a - formyloxy - 11,12 - diketo - cholanic acid or 3a - hemi - succinyloxy - 11,12 - diketo-cholonic acid. Specification 810,009 is referred to.ALSO:A therapeutic composition in the form of a capsule, granule, pastille or lozenge contains as the active ingredient a physiologically acceptable salt of 3a -hemi-succinyloxy-11-hydroxy - 12 - keto - D 9,11 - cholenic acid. The salt may be derived from an organic or inorganic base, the disodium salt being particularly referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR822953X | 1956-02-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB822953A true GB822953A (en) | 1959-11-04 |
Family
ID=9281149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5447/57A Expired GB822953A (en) | 1956-02-29 | 1957-02-18 | New derivative of dihydroxyketocholenic acid and process for its production |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB822953A (en) |
-
1957
- 1957-02-18 GB GB5447/57A patent/GB822953A/en not_active Expired
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