GB818724A - Hydantoin derivatives - Google Patents
Hydantoin derivativesInfo
- Publication number
- GB818724A GB818724A GB3172756A GB3172756A GB818724A GB 818724 A GB818724 A GB 818724A GB 3172756 A GB3172756 A GB 3172756A GB 3172756 A GB3172756 A GB 3172756A GB 818724 A GB818724 A GB 818724A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydantoin
- produce
- general formula
- represents hydrogen
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises hydantoin compounds of the general formula <FORM:0818724/IV (b)/1> (wherein R represents hydrogen or an alkyl group of not more than 4 carbon atoms), and the preparation thereof by subjecting the corresponding hydrindone-(1) of the formula <FORM:0818724/IV (b)/2> to the Bucherer hydantoin synthesis to produce the compound in which R is hydrogen, and alkylating this if desired. The products possess anticonvulsant properties. In examples: (1) 4-chlorohydrindone-(1) is warmed with ammonium carbonate and potassium cyanide in aqueous methanol to produce 4-chlorospirohydrindenyl - [1 : 51] - hydantoin: (2) the product of (1) is converted to its 31-methyl derivative by reaction with dimethyl sulphate in aqueous caustic soda. The Provisional Specification comprises compounds (analogously prepared) of the general formula <FORM:0818724/IV (b)/3> wherein R represents hydrogen or a lower alkyl radical and ring A bears at least one substituent, e.g. an alkyl (e.g. methyl or ethyl) or alkoxy (e.g. methoxy or ethoxy) radical or a halogen atom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3172756A GB818724A (en) | 1956-10-18 | 1956-10-18 | Hydantoin derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3172756A GB818724A (en) | 1956-10-18 | 1956-10-18 | Hydantoin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB818724A true GB818724A (en) | 1959-08-19 |
Family
ID=10327480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3172756A Expired GB818724A (en) | 1956-10-18 | 1956-10-18 | Hydantoin derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB818724A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2367754A1 (en) * | 1976-10-18 | 1978-05-12 | Pfizer | NEW HYDANTOIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
| US4181728A (en) * | 1978-11-16 | 1980-01-01 | Pfizer Inc. | Spiro-polycyclicimidazolidinedione derivatives |
| EP0115133A1 (en) * | 1982-12-06 | 1984-08-08 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
-
1956
- 1956-10-18 GB GB3172756A patent/GB818724A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2367754A1 (en) * | 1976-10-18 | 1978-05-12 | Pfizer | NEW HYDANTOIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
| US4181728A (en) * | 1978-11-16 | 1980-01-01 | Pfizer Inc. | Spiro-polycyclicimidazolidinedione derivatives |
| EP0115133A1 (en) * | 1982-12-06 | 1984-08-08 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
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