GB814570A - d-ª‡-methylphenethylamides and pharmaceutical preparations containing such amides - Google Patents
d-ª‡-methylphenethylamides and pharmaceutical preparations containing such amidesInfo
- Publication number
- GB814570A GB814570A GB7900/57A GB790057A GB814570A GB 814570 A GB814570 A GB 814570A GB 7900/57 A GB7900/57 A GB 7900/57A GB 790057 A GB790057 A GB 790057A GB 814570 A GB814570 A GB 814570A
- Authority
- GB
- United Kingdom
- Prior art keywords
- starch
- formic
- lactic
- gum
- methylphenethylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises N-d-a -methyl-phenethylamides of the formula C6H5.CH2.CH(CH3).NH.CO.R in which R is hydrogen, HOCH2-, or CH3.CHOH-, and their preparation by reacting d-a -methylphenethylamine with formic, glycolic or lactic acid, or an ester thereof, refluxing the mixture and separating the product. The products are used therapeutically. In examples, d-a -methylphenethylamine is heated with (1) ethyl lactate; (2) lactide; (3) ethyl formate or ethylene diformate; and (4) ethyl glycollate, to form the corresponding lactic, formic or glycollic amides.ALSO:Nervous stimulant pharmaceutical compositions comprise a N-d-a -methylphenylethylamide of formic, lactic or glycolic acid of the formula C6H5.CH2.CH(CH3).NH.CO.R, wherein R is H, -CH2OH or -CH(OH).CH2, and an excipient. The compounds can be administered parenterally, but are more preferably administered orally in combination with a non-toxic edible excipient. Suitable excipients include lactose, sugar, starch, pre-gelatinized starch, gum arabic, gum tragacanth, gum acacia, magnesium stearate, talc and corn starch. An example describes a preparation suitable for tablets or capsules containing N-d-a -methylphenylethyl, lactamide, sugar, starch, gum acacia, talc, magnesium stearate and stearic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US814570XA | 1956-03-22 | 1956-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB814570A true GB814570A (en) | 1959-06-10 |
Family
ID=22164284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7900/57A Expired GB814570A (en) | 1956-03-22 | 1957-03-11 | d-ª‡-methylphenethylamides and pharmaceutical preparations containing such amides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB814570A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3045043A (en) * | 1958-08-30 | 1962-07-17 | Hoechst Ag | New gamma-hydroxy-carboxylic acid amides and process for their manufacture |
| WO2006046853A1 (en) * | 2004-10-29 | 2006-05-04 | Quest International Services B.V. | Flavour modulating substances |
| US7897190B2 (en) | 2004-10-29 | 2011-03-01 | Quest International Services B.V. | Flavour modulating substances |
-
1957
- 1957-03-11 GB GB7900/57A patent/GB814570A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3045043A (en) * | 1958-08-30 | 1962-07-17 | Hoechst Ag | New gamma-hydroxy-carboxylic acid amides and process for their manufacture |
| WO2006046853A1 (en) * | 2004-10-29 | 2006-05-04 | Quest International Services B.V. | Flavour modulating substances |
| US7897190B2 (en) | 2004-10-29 | 2011-03-01 | Quest International Services B.V. | Flavour modulating substances |
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