GB806950A - Production of pharmaceutical preparations - Google Patents
Production of pharmaceutical preparationsInfo
- Publication number
- GB806950A GB806950A GB359756A GB359756A GB806950A GB 806950 A GB806950 A GB 806950A GB 359756 A GB359756 A GB 359756A GB 359756 A GB359756 A GB 359756A GB 806950 A GB806950 A GB 806950A
- Authority
- GB
- United Kingdom
- Prior art keywords
- micro
- agent
- per cent
- propiolactone
- organism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36161—Methods of inactivation or attenuation
- C12N2770/36163—Methods of inactivation or attenuation by chemical treatment
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A process for the manufacture of material containing antigens, obtained by the use of carcinogenic inactivating agents defined as to mean b -propiolactone or compounds of the formula <FORM:0806950/VI/1> where R is methyl, ethyl and normal or isopropyl, which includes the step of freeze drying in order to reverse excess of the carcinogenic agent. The material containing antigens is prepared by subjecting infectious micro-organisms to the action of the above inactivating agents, e.g. by subjecting a 20 per cent w/v. suspension of the micro-organism and animal tissue in sterile saline, to b -propiolactone or N-acetylethyleneimine in the form of an aqueous solution in which the concentration of said agent is between 0.005 per cent v/v. and 1 per cent v/v. based on the combined volumes of the, e.g. suspension of micro-organism and the solution of said agent. Sugars, e.g. sucrose may preferably be added to the material prior to freeze drying, which step is carried out at a low pressure, for example between 0.01 mm. and 0.0001 mm., during a period of several hours, e.g. 24 hours. The freeze-drying is conveniently carried out in ampoules. Specification 806,949 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB359756A GB806950A (en) | 1956-02-06 | 1956-02-06 | Production of pharmaceutical preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB359756A GB806950A (en) | 1956-02-06 | 1956-02-06 | Production of pharmaceutical preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB806950A true GB806950A (en) | 1959-01-07 |
Family
ID=9761333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB359756A Expired GB806950A (en) | 1956-02-06 | 1956-02-06 | Production of pharmaceutical preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB806950A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0203909A1 (en) * | 1985-04-26 | 1986-12-03 | IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte | Early-summer meningo-encephalitis virus (FSME-virus) vaccine, and method of producing the same |
-
1956
- 1956-02-06 GB GB359756A patent/GB806950A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0203909A1 (en) * | 1985-04-26 | 1986-12-03 | IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte | Early-summer meningo-encephalitis virus (FSME-virus) vaccine, and method of producing the same |
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