GB793558A - Improvements in or relating to tetracycline preparations - Google Patents

Improvements in or relating to tetracycline preparations

Info

Publication number
GB793558A
GB793558A GB19657/55A GB1965755A GB793558A GB 793558 A GB793558 A GB 793558A GB 19657/55 A GB19657/55 A GB 19657/55A GB 1965755 A GB1965755 A GB 1965755A GB 793558 A GB793558 A GB 793558A
Authority
GB
United Kingdom
Prior art keywords
acid
water
tetracycline
chlortetracycline
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19657/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Pfizer Inc
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Publication of GB793558A publication Critical patent/GB793558A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mineral and strong organic acid addition salts of tetracycline or chlortetracycline are prepared by dissolving the amphoteric antibiotic in methyl "Cellosolve" (Registered Trade Mark), and adding one equivalent of the acid dissolved in water. Specified are salts with hydrochloric, hydrobromic, hydriodic, sulphuric and nitric acids.ALSO:A therapeutically effective composition useful for the preparation of intramuscularly injectable liquid preparations comprises a mixture of an acid addition salt of tetracycline or chlortetracycline (see Group IV (b)) and magnesium chloride. It is preferred to use two molecules of magnesium chloride to one molecule of the antibiotic. Specified acid addition salts are the hydrochloride, hydrobromide, hydroiodide, sulphate and nitrate. The injectable vehicle may be water, propylene glycol or oils such as sesame and peanut oils. Optional ingredients for aqueous injections are (a) a non-toxic, water-soluble organic acid, e.g. citric, gluconic, lactic, ascorbic, maleic, malic, malonic and nicotinic acids, an hydroxy acid, or a compound which on addition of water forms such an acid, e.g. glucurono-lactone; and (b) a water-soluble local anaesthetic, e.g. procaine hydrochloride and other dialkylamino alkanol esters of p-aminobenzoic acid.
GB19657/55A 1954-07-07 1955-07-07 Improvements in or relating to tetracycline preparations Expired GB793558A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US793558XA 1954-07-07 1954-07-07

Publications (1)

Publication Number Publication Date
GB793558A true GB793558A (en) 1958-04-16

Family

ID=22150009

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19657/55A Expired GB793558A (en) 1954-07-07 1955-07-07 Improvements in or relating to tetracycline preparations

Country Status (1)

Country Link
GB (1) GB793558A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004894A (en) * 1959-04-07 1961-10-17 Upjohn Co Therapeutic composition comprising tetracycline and a dioxolane
US9084802B2 (en) 2010-05-12 2015-07-21 Rempex Pharmaceuticals, Inc. Tetracycline compositions

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004894A (en) * 1959-04-07 1961-10-17 Upjohn Co Therapeutic composition comprising tetracycline and a dioxolane
US9084802B2 (en) 2010-05-12 2015-07-21 Rempex Pharmaceuticals, Inc. Tetracycline compositions
US9278105B2 (en) 2010-05-12 2016-03-08 Rempex Pharmaceuticals, Inc. Tetracycline compositions
US9744179B2 (en) 2010-05-12 2017-08-29 Rempex Pharmaceuticals, Inc. Tetracycline compositions
US11944634B2 (en) 2010-05-12 2024-04-02 Melinta Subsidiary Corp. Tetracycline compositions

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