GB774991A - Improvements in or relating to novel chemical compounds useful in the synthesis of lysergic acid and its homologues and process for preparing such compounds - Google Patents
Improvements in or relating to novel chemical compounds useful in the synthesis of lysergic acid and its homologues and process for preparing such compoundsInfo
- Publication number
- GB774991A GB774991A GB20247/55A GB2024755A GB774991A GB 774991 A GB774991 A GB 774991A GB 20247/55 A GB20247/55 A GB 20247/55A GB 2024755 A GB2024755 A GB 2024755A GB 774991 A GB774991 A GB 774991A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- homologues
- acid
- relating
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises octahydro-indolo-quinolines (ergolenes) of the formula <FORM:0774991/IV(b)/1> where R1 and R2 are C1-C8 alkyl, an acid addition salts thereof. These are made from 4 - acyl - 7 - alkyl - 9 - cyano - ergolenes of the formula <FORM:0774991/IV(b)/2> by treatment with the appropriate alkanol in the presence of an acid; R is C1-C8 alkyl, monocyclic aryl or monocyclic aralkyl having 1-8 carbon atoms in the side chain (see Specification 774,990). An example is given of the preparation of 9-carbomethoxy-7-methyl-10-ergolene from 4 - acetyl - 9 - cyano - 7 - methyl - 10 - ergolene with methanol and sulphuric acid. Other starting materials may be used in which R is methyl or phenyl, R1 is methyl, ethyl, propyl or n-heptyl and R2 is methyl or isopropyl. The products may be converted into lysergic acid and its homologues as described in Specifications 774,984 and 774,992.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US774991XA | 1954-09-27 | 1954-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB774991A true GB774991A (en) | 1957-05-15 |
Family
ID=22138435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB20247/55A Expired GB774991A (en) | 1954-09-27 | 1954-10-25 | Improvements in or relating to novel chemical compounds useful in the synthesis of lysergic acid and its homologues and process for preparing such compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB774991A (en) |
-
1954
- 1954-10-25 GB GB20247/55A patent/GB774991A/en not_active Expired
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