GB773292A - 2-aryl-3-amino-butan-2-ols and process for preparing same - Google Patents

2-aryl-3-amino-butan-2-ols and process for preparing same

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Publication number
GB773292A
GB773292A GB25572/55A GB2557255A GB773292A GB 773292 A GB773292 A GB 773292A GB 25572/55 A GB25572/55 A GB 25572/55A GB 2557255 A GB2557255 A GB 2557255A GB 773292 A GB773292 A GB 773292A
Authority
GB
United Kingdom
Prior art keywords
methoxy
methoxyphenyl
butan
product
methyl magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25572/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Canada Inc
Original Assignee
Ayerst Mckenna and Harrison Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayerst Mckenna and Harrison Inc filed Critical Ayerst Mckenna and Harrison Inc
Publication of GB773292A publication Critical patent/GB773292A/en
Expired legal-status Critical Current

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Abstract

The invention comprises compounds of the formula <FORM:0773292/IV(b)/1> and acid addition salts thereof, wherein R is an alkyl group of up to 4 carbon atoms or a benzyl radical, and their preparation by reacting the corresponding o-methoxyphenyl a -aminoethyl ketone with a methyl magnesium halide Grignard reagent and hydrolysing the product with dilute acid. The compounds are used for the treatment of bronchitis, asthma and other pulmonary conditions. In examples: (1) o-methoxy - a - benzylaminopropiophenone is treated with methyl magnesium iodide in ether and the product is hydrolysed to give 3-benzylamino - 2 - (o - methoxyphenyl - butan - 2 - ol and its hydrochloride; and (2) o-methoxy-a -isopropylaminopropiophenone is treated with methyl magnesium iodide and the product is hydrolysed to give 3-isopropylamino-2-(o-methoxyphenyl)-butan-2-o and its hydrochloride. Starting materials. The o-methoxyphenyl-a -aminoethyl ketones used as starting materials such as o-methoxy-a -benzylaminopropiophenone and o - methoxy - a - isopropylaminopropiophenone are made by reacting o-methoxy-a -bromopropiophenone with an alkyl or aralkyl amine.
GB25572/55A 1954-10-06 1955-09-06 2-aryl-3-amino-butan-2-ols and process for preparing same Expired GB773292A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US773292XA 1954-10-06 1954-10-06

Publications (1)

Publication Number Publication Date
GB773292A true GB773292A (en) 1957-04-24

Family

ID=22137428

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25572/55A Expired GB773292A (en) 1954-10-06 1955-09-06 2-aryl-3-amino-butan-2-ols and process for preparing same

Country Status (1)

Country Link
GB (1) GB773292A (en)

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