GB762702A - Improvements in or relating to the production of erythromycin - Google Patents

Improvements in or relating to the production of erythromycin

Info

Publication number
GB762702A
GB762702A GB16257/54A GB1625754A GB762702A GB 762702 A GB762702 A GB 762702A GB 16257/54 A GB16257/54 A GB 16257/54A GB 1625754 A GB1625754 A GB 1625754A GB 762702 A GB762702 A GB 762702A
Authority
GB
United Kingdom
Prior art keywords
oil
ester
erythromycin
culture medium
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16257/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB762702A publication Critical patent/GB762702A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Erythromycin is produced in increased yield by growing an erythromycin-producing-microorganism especially a suitable strain of Streptomyces erythreus in a culture medium containing an ester of a long-chain fatty acid having at least 12 carbon atoms in an amount of at least 0.25 per cent by volume of the nutrient medium. The ester may be added prior to inoculation with the micro-organism or intermittently during the fermentation. The ester may be a triglyceride, e.g. glyceryl trioleate, or a naturally occurring animal or vegetable fat or oil, e.g. lard oil, corn oil, soybean oil, cottonseed oil, sesame oil, olive oil, coconut oil and margarine oil. It is preferred to add 0.25 to 6.0 per cent ester based on the volume of the culture medium. The methods of cultivation and the composition of the culture medium are according to those disclosed in Specification 708,159.
GB16257/54A 1953-06-02 1954-06-01 Improvements in or relating to the production of erythromycin Expired GB762702A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US762702XA 1953-06-02 1953-06-02

Publications (1)

Publication Number Publication Date
GB762702A true GB762702A (en) 1956-12-05

Family

ID=22130932

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16257/54A Expired GB762702A (en) 1953-06-02 1954-06-01 Improvements in or relating to the production of erythromycin

Country Status (1)

Country Link
GB (1) GB762702A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013947A (en) * 1960-06-14 1961-12-19 Glaxo Lab Ltd Antibiotic production
CN107653285A (en) * 2017-11-22 2018-02-02 宁夏启元药业有限公司 A kind of culture medium and its fermentation process using streptomyces erythreus fermenting and producing erythromycin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013947A (en) * 1960-06-14 1961-12-19 Glaxo Lab Ltd Antibiotic production
CN107653285A (en) * 2017-11-22 2018-02-02 宁夏启元药业有限公司 A kind of culture medium and its fermentation process using streptomyces erythreus fermenting and producing erythromycin

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