GB738629A - Improvements relating to new 11-keto compounds of the androstene series and the preparation thereof - Google Patents
Improvements relating to new 11-keto compounds of the androstene series and the preparation thereofInfo
- Publication number
- GB738629A GB738629A GB32087/53A GB3208753A GB738629A GB 738629 A GB738629 A GB 738629A GB 32087/53 A GB32087/53 A GB 32087/53A GB 3208753 A GB3208753 A GB 3208753A GB 738629 A GB738629 A GB 738629A
- Authority
- GB
- United Kingdom
- Prior art keywords
- keto
- androstene
- preparation
- new
- improvements relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 11-keto-testosterones and esters thereof of the general formula <FORM:0738629/IV (b)/1> wherein R represents hydrogen or the acyl residue of a fatty acid having 1 to 4 carbon atoms or benzoic acid, and the preparation thereof by oxidizing a D 4-androstene-3-one-11b ,17b -diol-17-ester in acidic chromic acid solution and, if desired, hydrolysing the 11-keto-testosterone ester thus formed with aqueous alkali to yield 11-keto-testosterone. The oxidation may be carried out in the presence of glacial acetic acid, a suitable temperature for the oxidation being 10 DEG to 100 DEG C. The aqueous alkali may be an aqueous solution of an alkali metal or alkaline earth metal hydroxide, carbonate or bicarbonate. In the examples: D 4 - androstene - 17b - ol - 3,11 - dione and the 17b - ol - acetate thereof are prepared. Specification 737,773 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US738629XA | 1952-12-06 | 1952-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB738629A true GB738629A (en) | 1955-10-19 |
Family
ID=22116253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB32087/53A Expired GB738629A (en) | 1952-12-06 | 1953-11-19 | Improvements relating to new 11-keto compounds of the androstene series and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB738629A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1587574A2 (en) * | 2001-12-21 | 2005-10-26 | Rhode Island Hospital | SELECTIVE 11b-HSD INHIBITORS AND METHODS FOR USE THEREOF |
-
1953
- 1953-11-19 GB GB32087/53A patent/GB738629A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1587574A2 (en) * | 2001-12-21 | 2005-10-26 | Rhode Island Hospital | SELECTIVE 11b-HSD INHIBITORS AND METHODS FOR USE THEREOF |
EP1587574A4 (en) * | 2001-12-21 | 2009-03-18 | Rhode Island Hospital | SELECTIVE 11b-HSD INHIBITORS AND METHODS FOR USE THEREOF |
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