GB725683A - Improvements in or relating to storage-stable pteroyl solutions - Google Patents
Improvements in or relating to storage-stable pteroyl solutionsInfo
- Publication number
- GB725683A GB725683A GB3396/53A GB339653A GB725683A GB 725683 A GB725683 A GB 725683A GB 3396/53 A GB3396/53 A GB 3396/53A GB 339653 A GB339653 A GB 339653A GB 725683 A GB725683 A GB 725683A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- solution
- pteroyl
- methylaminopteroylglutamic
- dimethylaminopteroylglutamic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A storage-stable aqueous pteroyl solution especially for parenteral injection comprises one or more pteroyl compounds and 0.01-0.5 per cent alkali metal salt of ethylene diamine tetraacetic acid, the pH of the solution being 7-10. Mono-, di-, tri- and tetra-sodium, potassium or lithium salts may be used, and may be formed by neutralization of the acid in the solution. The term "pteroyl compounds" means folic acid and folic acid-containing materials such as liver extracts and their equivalents, e.g. pteroylglutamyl-glutamyl glutamate, 4-amino-10-methylpteroylglutamic acid, 4-aminopteroyl-glutamic acid, 4-aminopteroylaspartic acid, 9-methylpteroylglutamic acid, 4-amino-9,10-dimethylglutamic acid, N5 - formyltetrahydropteroylglutamic acid, 2,4-dihydroxy-pteroylglutamic acid, 2 methylaminopteroylglutamic acid, 2 - dimethylaminopteroylglutamic acid, 4 - methylaminopteroylglutamic acid, 4 - dimethylaminopteroylglutamic acid. An example discloses the use also of crystalline Vitamin B12 in the preparation of a solution.ALSO:A storage-stable aqueous pteroyl solution especially for parenteral injection comprises one or more pteroyl compounds and 0.01-0.5 per cent alkali metal salt of ethylene diamine tetraacetic acid, the pH of the solution being 7-10. Mono-, di-, tri- and tetra-sodium, potassium or lithium salts may be used, and may be formed by neutralization of the acid in the solution. The term "pteroyl compounds" means folic acid and folic acid-containing materials such as liver extracts and their equivalents e.g. pteroylglutamyl-glutamyl glutamate, 4-amino-10-methylpteroylglutamic acid, 4-aminopteroylglutamic acid, 4-aminopteroylaspartic acid, 9-methylpteroylglutamic acid, 4-amino-9, 10-dimethylglutamic acid, N5 formyltetrahydropteroylglutamic acid, 2, 4-dihydroxypteroylglutamic acid, 2-methylaminopteroylglutamic acid, 2-dimethylaminopteroylglutamic acid, 4-methylaminopteroylglutamic acid, 4-dimethylaminopteroylglutamic acid. An example discloses the use also of crystalline vitamin B12 in the preparation of a solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US725683XA | 1952-04-29 | 1952-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB725683A true GB725683A (en) | 1955-03-09 |
Family
ID=22108448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3396/53A Expired GB725683A (en) | 1952-04-29 | 1953-02-06 | Improvements in or relating to storage-stable pteroyl solutions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB725683A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0319598A1 (en) * | 1987-12-07 | 1989-06-14 | Holger Blum | Stabilized aqueous preparation of folic acid |
| FR2816944A1 (en) * | 2000-11-17 | 2002-05-24 | Dospharma | Lithium salts of folic, folinic and glutamic acids useful for the treatment of depression, giving more consistent effects between individuals |
-
1953
- 1953-02-06 GB GB3396/53A patent/GB725683A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0319598A1 (en) * | 1987-12-07 | 1989-06-14 | Holger Blum | Stabilized aqueous preparation of folic acid |
| FR2816944A1 (en) * | 2000-11-17 | 2002-05-24 | Dospharma | Lithium salts of folic, folinic and glutamic acids useful for the treatment of depression, giving more consistent effects between individuals |
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