GB718437A - Improvements in or relating to isocytosine derivatives - Google Patents

Improvements in or relating to isocytosine derivatives

Info

Publication number
GB718437A
GB718437A GB25218/51A GB2521851A GB718437A GB 718437 A GB718437 A GB 718437A GB 25218/51 A GB25218/51 A GB 25218/51A GB 2521851 A GB2521851 A GB 2521851A GB 718437 A GB718437 A GB 718437A
Authority
GB
United Kingdom
Prior art keywords
derivatives
isobutylaminoethoxy
amylaminoethoxy
isopropylaminoethoxy
butylaminoethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25218/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of GB718437A publication Critical patent/GB718437A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises isocytosine derivatives of the formula <FORM:0718437/IV (b)/1> where R and R1 are alkyl radicals of 3-8 carbon atoms, R11 is hydrogen or methyl and n is 2 or 3. These are made from the corresponding 4-halo-pyrimidines and the alkali metal derivatives of HO-(CH2)n-NRR1. The reaction is preferably carried out by heating the reactants to 80 DEG C. or less in an inert organic solvent, cooling, adding aqueous alkali to hydrolyse any unreacted alcoholate, separating the organic solvent solution and recovering the product from the latter. Suitable organic solvents are benzene and xylene. Examples describe the preparation of the 4-di-n-butylaminoethoxy, 4 - di - n - propylaminopropoxy and 4 - di - isobutylaminoethoxy - 2 - amino-pyrimidines and of the 4-di-isobutylaminoethoxy and 4 - di - n - butylaminoethoxy - 2-amino - 6 - methylpyrimidines. Hydrochloride and succinate salts are described. Other compounds mentioned are (R11=H) 4-di-isopropylaminoethoxy, 4 - di - n - amylaminopropoxy, 4 - di - n - butylaminopropoxy, 4 - di - n - amylaminoethoxy, 4 - di - isoamylaminoethoxy and 4-di-iso-octylaminoethoxy, and (R11 = methyl) 4 - di - n - propylaminoethoxy, 4 - di - isopropylaminoethoxy and 4 - di - n - amylaminoethoxy. Other salts mentioned are the maleates, tartrates, lactates and fumarates. The products are uterine stimulants or depressants and graphs are given showing their action.
GB25218/51A 1950-11-07 1951-10-29 Improvements in or relating to isocytosine derivatives Expired GB718437A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US718437XA 1950-11-07 1950-11-07

Publications (1)

Publication Number Publication Date
GB718437A true GB718437A (en) 1954-11-17

Family

ID=22103943

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25218/51A Expired GB718437A (en) 1950-11-07 1951-10-29 Improvements in or relating to isocytosine derivatives

Country Status (1)

Country Link
GB (1) GB718437A (en)

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