GB718437A - Improvements in or relating to isocytosine derivatives - Google Patents
Improvements in or relating to isocytosine derivativesInfo
- Publication number
- GB718437A GB718437A GB25218/51A GB2521851A GB718437A GB 718437 A GB718437 A GB 718437A GB 25218/51 A GB25218/51 A GB 25218/51A GB 2521851 A GB2521851 A GB 2521851A GB 718437 A GB718437 A GB 718437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- derivatives
- isobutylaminoethoxy
- amylaminoethoxy
- isopropylaminoethoxy
- butylaminoethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises isocytosine derivatives of the formula <FORM:0718437/IV (b)/1> where R and R1 are alkyl radicals of 3-8 carbon atoms, R11 is hydrogen or methyl and n is 2 or 3. These are made from the corresponding 4-halo-pyrimidines and the alkali metal derivatives of HO-(CH2)n-NRR1. The reaction is preferably carried out by heating the reactants to 80 DEG C. or less in an inert organic solvent, cooling, adding aqueous alkali to hydrolyse any unreacted alcoholate, separating the organic solvent solution and recovering the product from the latter. Suitable organic solvents are benzene and xylene. Examples describe the preparation of the 4-di-n-butylaminoethoxy, 4 - di - n - propylaminopropoxy and 4 - di - isobutylaminoethoxy - 2 - amino-pyrimidines and of the 4-di-isobutylaminoethoxy and 4 - di - n - butylaminoethoxy - 2-amino - 6 - methylpyrimidines. Hydrochloride and succinate salts are described. Other compounds mentioned are (R11=H) 4-di-isopropylaminoethoxy, 4 - di - n - amylaminopropoxy, 4 - di - n - butylaminopropoxy, 4 - di - n - amylaminoethoxy, 4 - di - isoamylaminoethoxy and 4-di-iso-octylaminoethoxy, and (R11 = methyl) 4 - di - n - propylaminoethoxy, 4 - di - isopropylaminoethoxy and 4 - di - n - amylaminoethoxy. Other salts mentioned are the maleates, tartrates, lactates and fumarates. The products are uterine stimulants or depressants and graphs are given showing their action.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US718437XA | 1950-11-07 | 1950-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB718437A true GB718437A (en) | 1954-11-17 |
Family
ID=22103943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB25218/51A Expired GB718437A (en) | 1950-11-07 | 1951-10-29 | Improvements in or relating to isocytosine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB718437A (en) |
-
1951
- 1951-10-29 GB GB25218/51A patent/GB718437A/en not_active Expired
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