GB682823A - Manufacture of 3:3-carbalkoxy-methylene-bis-(4-hydroxy-coumarins) - Google Patents
Manufacture of 3:3-carbalkoxy-methylene-bis-(4-hydroxy-coumarins)Info
- Publication number
- GB682823A GB682823A GB25816/50A GB2581650A GB682823A GB 682823 A GB682823 A GB 682823A GB 25816/50 A GB25816/50 A GB 25816/50A GB 2581650 A GB2581650 A GB 2581650A GB 682823 A GB682823 A GB 682823A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- methylene
- hydroxy
- manufacture
- carbalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
- C07D311/48—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring with two such benzopyran radicals linked together by a carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for the manufacture of 3 : 31-carbalkoxymethylene - bis - (4 - hydroxycoumarins) which are known to be blood anti-coagulants comprises the reaction of an alkali metal compound of a 4-hydroxy-coumarin with a dihalogen acetic acid alkyl ester in an alcoholic medium. Esters with alkyl groups containing up to 6 carbon atoms are referred to. In an example carbethoxy-methylene-bis-(4-hydroxycoumarin) is obtained by reacting the potassium compound of 4-hydroxycoumarin and ethyl dichloroacetate in absolute alcohol with a sodium iodide catalyst.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL296479X | 1949-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB682823A true GB682823A (en) | 1952-11-19 |
Family
ID=19782999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB25816/50A Expired GB682823A (en) | 1949-10-24 | 1950-10-23 | Manufacture of 3:3-carbalkoxy-methylene-bis-(4-hydroxy-coumarins) |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE498518A (en) |
CH (1) | CH296479A (en) |
FR (1) | FR1035566A (en) |
GB (1) | GB682823A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE952813C (en) * | 1954-03-06 | 1956-11-22 | Asal Fabrik Biolog Und Pharmaz | Process for the preparation of bis (4-oxycoumarin) sulfide |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2872457A (en) * | 1956-04-19 | 1959-02-03 | Wisconsin Alumni Res Found | Process for the preparation of 4-hydroxycoumarin derivatives |
-
0
- BE BE498518D patent/BE498518A/xx unknown
-
1950
- 1950-10-17 CH CH296479D patent/CH296479A/en unknown
- 1950-10-18 FR FR1035566D patent/FR1035566A/en not_active Expired
- 1950-10-23 GB GB25816/50A patent/GB682823A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE952813C (en) * | 1954-03-06 | 1956-11-22 | Asal Fabrik Biolog Und Pharmaz | Process for the preparation of bis (4-oxycoumarin) sulfide |
Also Published As
Publication number | Publication date |
---|---|
BE498518A (en) | |
CH296479A (en) | 1954-02-15 |
FR1035566A (en) | 1953-08-26 |
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