GB642971A - Improvements in therapeutic preparations - Google Patents

Improvements in therapeutic preparations

Info

Publication number
GB642971A
GB642971A GB3402347A GB3402347A GB642971A GB 642971 A GB642971 A GB 642971A GB 3402347 A GB3402347 A GB 3402347A GB 3402347 A GB3402347 A GB 3402347A GB 642971 A GB642971 A GB 642971A
Authority
GB
United Kingdom
Prior art keywords
acid
ammonium
toxic
parts
salicylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3402347A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOLCIN Ltd
Original Assignee
DOLCIN Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOLCIN Ltd filed Critical DOLCIN Ltd
Priority to GB3402347A priority Critical patent/GB642971A/en
Publication of GB642971A publication Critical patent/GB642971A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Therapeutic substances such as salicylate drugs, cincophen, amidopyrine and the sulphonamides, which ordinarily have a toxic or depressant effect on tissue metabolism or tissue respiration when adminisstered in frequent and extended dosages, are rendered non-toxic at such dosages by admixture with at least one non-toxic aliphatic, polycarboxylic acid substance of general formula R1(COOR)x where x=2 or 3; R=hydrogen, ammonium, alkali metal or alkaline earth metal; and R1 is succinic, fumaric, malic, oxalacetic, cisaconitic, isocitric or -ketoglutaric acids stripped of their carboxyl groups. The dibasic acids and in particular succinic acid, are preferred. Succinic acid and its ammonium, sodium or calcium salts are particularly effective. In one example, tablets are prepared from 3 parts of calcium succinate and 4 parts of acetylsalicylic acid. Effective compositions have 1/3 to 10 parts of calcium succinate to 1 part of acetylsalicylic acid, although a ratio of 1:1 to 3:1 is preferred. By a salicylate drug is intended salicylic acid, its esters such as ethyl salicylate, its acyl derivatives such as acetylsalicylic acid and methylene citryl salicylic acid and the ammonium, alkali and alkaline earth metal salts of such acids. Sulphathiazole and "Atebria" (R.T.M.) are other specified therapeutic substances.
GB3402347A 1947-12-23 1947-12-23 Improvements in therapeutic preparations Expired GB642971A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3402347A GB642971A (en) 1947-12-23 1947-12-23 Improvements in therapeutic preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3402347A GB642971A (en) 1947-12-23 1947-12-23 Improvements in therapeutic preparations

Publications (1)

Publication Number Publication Date
GB642971A true GB642971A (en) 1950-09-13

Family

ID=10360402

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3402347A Expired GB642971A (en) 1947-12-23 1947-12-23 Improvements in therapeutic preparations

Country Status (1)

Country Link
GB (1) GB642971A (en)

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