Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1063547A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation LtdfiledCriticalWellcome Foundation Ltd
Priority to GB1063547ApriorityCriticalpatent/GB623255A/en
Publication of GB623255ApublicationCriticalpatent/GB623255A/en
Micro-Organisms Or Cultivation Processes Thereof
(AREA)
Abstract
In the recovery of an antibiotic from the metabolism fluid of the bacillus known as B. aerosporus Greer or B. polymyoca (Praymowski) Migula, by the process of Specification 619,572, the first treatment with charcoal is preceded by heating under acid conditions, preferably in the presence of hydrochloric acid (e.g. 2 per cent by weight of the mixture of 40 per cent hydrochloric acid), or sulphuric acid. The time and temperature of heating (e.g. 30 minutes at 80 DEG C.) and the acidity (pH below 6, preferably about 2.5) should be such that at least 90 per cent of the gummy impurity present is converted into a non-gummy form while leaving at least 90 per cent of the antibiotic activity unimpaired. If the metabolism fluid already has a pH below 6, the addition of further acid, though desirable, is not essential.
GB1063547A1947-04-211947-04-21Improvements in and relating to the production of an antibiotic
ExpiredGB623255A
(en)