GB562349A - Improvements relating to the manufacture of sulphanilamide derivatives - Google Patents

Improvements relating to the manufacture of sulphanilamide derivatives

Info

Publication number
GB562349A
GB562349A GB237543A GB237543A GB562349A GB 562349 A GB562349 A GB 562349A GB 237543 A GB237543 A GB 237543A GB 237543 A GB237543 A GB 237543A GB 562349 A GB562349 A GB 562349A
Authority
GB
United Kingdom
Prior art keywords
ethyl
sulphanilamidosalicylate
sulphanilamidobenzoate
aralkyl
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB237543A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB237543A priority Critical patent/GB562349A/en
Publication of GB562349A publication Critical patent/GB562349A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Abstract

Sulphanilamido acylamides of the general formula H2N.C6H4.SO2NH.X.CONH2 are prepared by the action of concentrated aqueous ammonia on compounds of the formula R1HN.C6H4.SO2.NR1.X.CO.OR, where X may be an alkyl, aryl, aralkyl or heterocyclic residue, R1 may be hydrogen or acyl and R may be alkyl, aryl, or aralkyl. The reaction is preferably carried out by heating in an autoclave for about two hours at about 150 DEG C. Examples are given of the treatment with ammonia of (1) ethyl 4-sulphanilamidobenzoate; (2) ethyl N1N4-diacetyl-4-sulphanilamidobenzoate; (3) ethyl 3-sulphanilamidocinnamate; (4) ethyl sulphanilamidoacetate; (5) ethyl 5-sulphanilamidosalicylate; (6) ethyl 3-sulphanilamidosalicylate; (7) ethyl 3-aminopicolinate. In each case the corresponding amide is formed with simultaneous regeneration of the free amino groups. Specification 486,421 is referred to.
GB237543A 1943-02-12 1943-02-12 Improvements relating to the manufacture of sulphanilamide derivatives Expired GB562349A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB237543A GB562349A (en) 1943-02-12 1943-02-12 Improvements relating to the manufacture of sulphanilamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB237543A GB562349A (en) 1943-02-12 1943-02-12 Improvements relating to the manufacture of sulphanilamide derivatives

Publications (1)

Publication Number Publication Date
GB562349A true GB562349A (en) 1944-06-28

Family

ID=9738438

Family Applications (1)

Application Number Title Priority Date Filing Date
GB237543A Expired GB562349A (en) 1943-02-12 1943-02-12 Improvements relating to the manufacture of sulphanilamide derivatives

Country Status (1)

Country Link
GB (1) GB562349A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507474A1 (en) * 1981-06-16 1982-12-17 Choay Sa Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity
FR2507598A1 (en) * 1981-06-16 1982-12-17 Choay Sa Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity
EP0068968A1 (en) * 1981-06-16 1983-01-05 Choay S.A. Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507474A1 (en) * 1981-06-16 1982-12-17 Choay Sa Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity
FR2507598A1 (en) * 1981-06-16 1982-12-17 Choay Sa Benzene, thiophene and pyrimidine sulphonamido alkanoic acid derivs. - are normolipaemic cpds. with good therapeutic index, have low toxicity
EP0068968A1 (en) * 1981-06-16 1983-01-05 Choay S.A. Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation

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