GB2594235A - Ammonia sensor - Google Patents
Ammonia sensor Download PDFInfo
- Publication number
- GB2594235A GB2594235A GB2000850.4A GB202000850A GB2594235A GB 2594235 A GB2594235 A GB 2594235A GB 202000850 A GB202000850 A GB 202000850A GB 2594235 A GB2594235 A GB 2594235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- ammonia sensor
- vinyl
- sensor according
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/202—Assessing bladder functions, e.g. incontinence assessment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/44—Devices worn by the patient for reception of urine, faeces, catamenial or other discharge; Portable urination aids; Colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/08—Elderly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
- A61B2505/07—Home care
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0266—Operational features for monitoring or limiting apparatus function
- A61B2560/0276—Determining malfunction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/207—Sensing devices adapted to collect urine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Optics & Photonics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- Nursing (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The present invention relates to an ammonia sensor for use in a catheter drainage system. The present invention also relates to a catheter, drainage bag or connection unit comprising the ammonia sensor of the present invention, methods of using the ammonia sensor and methods of making the ammonia sensor.
Claims (20)
1. An ammonia sensor for incorporation into a catheter drainage system wherein the ammonia sensor is obtained by curing a composition, the composition comprising: a) 70 to 95 % by weight vinyl-terminated polydimethylsiloxanes, comprising vinyl-terminated polydimethylsiloxane having a molecular weight of 100000 to 125000, vinyl-terminated polydimethylsiloxane having a molecular weight of 25000 and 35000 and vinyl-terminated polydimethylsiloxane having a molecular weight of 4000 to 8000; b) 1 to 10 % by weight untreated fumed silica; c) 1 to 5 % by weight a pH indicator; and d) 1 to 4 % by weight a cross linker.
2. The ammonia sensor according to claim 1, wherein the composition comprises 75 to 90% by weight vinyl-terminated polydimethylsiloxanes, preferably 80 to 85% by weight vinyl-terminated polydimethylsiloxanes.
3. The ammonia sensor according to claim 1 or 2, wherein the composition comprises 30-50% by weight vinyl-terminated polydimethylsiloxane having a molecular weight of 100000 to 125000, 25 to 45% by weight vinyl-terminated polydimethylsiloxane having a molecular weight of 25000 to 35000 and 1 to 5% by weight vinyl-terminated polydimethylsiloxane having a molecular weight of 4000 to 8000.
4. The ammonia sensor according to any preceding claim, wherein the composition comprises vinyl-terminated polydimethylsiloxane with a molecular weight of 117000, vinyl-terminated polydimethylsiloxane with a molecular weight of 28000 and vinyl-terminated polydimethylsiloxane with a molecular weight of 6000.
5. The ammonia sensor according to any preceding claim, wherein the untreated fumed silica has an average particle size in the range 0.1 to 0.5 microns, preferably 0.15 to 0.4 microns.
6. The ammonia sensor according to any preceding claim, wherein the untreated fumed silica has a BET surface area in the range 150 to 250 m2/g.
7. The ammonia sensor according to any preceding claim, wherein the composition comprises 2 to 5% by weight untreated fumed silica, preferably wherein the composition comprises about 3% by weight untreated fumed silica.
8. The ammonia sensor according to any preceding claim, wherein the cross linker is methylhydrosiloxane - dimethylsiloxane copolymers, trimethylsiloxy terminated, preferably wherein the cross linker has a molecular weight of 900 to 65000, more preferably wherein the cross linker has a molecular weight of 900 to 2000.
9. The ammonia sensor according to any preceding claim, wherein the composition comprises 1.5 to 3.5% by weight cross linker, preferably wherein the composition comprises about 2.5% by weight cross linker.
10. The ammonia sensor according to any one of the preceding claims, wherein the pH indicator is selected from neutral red, bromothymol blue, bromothymol blue sodium salt, cresol red, phenol red, 3-(m)-nitrophenol, fluorescein and rosolic acid, preferably wherein the pH indicator is bromothymol blue sodium salt.
11. The ammonia sensor according to any one of the preceding claims, wherein the composition comprises 2 to 3% by weight pH indicator.
12. The ammonia sensor according to any preceding claim, wherein the composition additionally comprises a matrix stabiliser, preferably wherein the composition comprises 5 to 15 % by weight of a matrix stabiliser, more preferably 8 to 10% by weight of a matrix stabiliser.
13. The ammonia sensor according to claim 12, wherein the matrix stabiliser is a quaternary ammonium compound, preferably wherein the matrix stabiliser is cetrimonium bromide.
14. The ammonia sensor according to any preceding claim, wherein the composition additionally comprises an accelerator, preferably where the accelerator is a platinum catalyst, more preferably wherein the accelerator is Pt- divinyltetramethyldisiloxane complex.
15. The ammonia sensor according to claim 14, wherein the platinum catalyst is present in the composition at a level of 0.1 to 0.2 % by weight.
16. An ammonia sensor for incorporation into a catheter drainage system that comprises a polymer matrix comprising: 70 to 95 % by weight cross linked polydimethylsiloxanes, comprising cross linked polydimethylsiloxanes having a molecular weight of 100,000 to 125,000, cross linked polydimethylsiloxanes having a molecular weight of 25,000 and 35,000 and cross linked polydimethylsiloxanes having a molecular weight of 4,000 to 8,000; wherein the polymer matrix encapsulates 1 to 10% by weight untreated fumed silica and 1 to 5% by weight a pH indicator.
17. An article comprising an ammonia sensor according to any one of the preceding claims, wherein the article is a catheter, a drainage bag, a drainage unit or a connection unit.
18. Use of the ammonia sensor according to any one of claims 1 to 16 for predicting impending catheter encrustation and blockage, comprising positioning the ammonia sensor in the flow of urine from a catheter and monitoring for a change in the ammonia sensor indicating the presence of ammonia in the urine.
19. A method of making an ammonia sensor according to any of claims 1 to 16, the method comprising the steps of: preparing a composition comprising: a) 70 to 95 % by weight vinyl-terminated polydimethylsiloxanes, comprising vinyl-terminated polydimethylsiloxane having a molecular weight of 100000 to 125000, vinyl-terminated polydimethylsiloxane having a molecular weight of 25000 and 35000 and vinyl-terminated polydimethylsiloxane having a molecular weight of 4000 to 8000; b) 1 to 10 % by weight untreated fumed silica; c) 1 to 5 % by weight a pH indicator; and d) 1 to 4 % by weight a cross linker; and curing the composition to form a sensor.
20. The method of claim 18, wherein the composition is made by: preparing a silicone base with the vinyl-terminated polydimethylsiloxanes and untreated fumed silica; splitting the silicone base into first and second parts; adding a matrix stabiliser, pH indicator and accelerator to the first part; adding a matrix stabiliser, pH indicator and cross linker to the second part; and mixing the first and second parts together to form the composition.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2019/053224 WO2021094702A1 (en) | 2019-11-14 | 2019-11-14 | Ammonia sensor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB202000850D0 GB202000850D0 (en) | 2020-03-04 |
| GB2594235A true GB2594235A (en) | 2021-10-27 |
Family
ID=68696454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2000850.4A Pending GB2594235A (en) | 2019-11-14 | 2019-11-14 | Ammonia sensor |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2022510519A (en) |
| CN (1) | CN113133318A (en) |
| GB (1) | GB2594235A (en) |
| WO (1) | WO2021094702A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110945076B (en) | 2017-09-12 | 2023-10-17 | 苏黎士联邦理工大学 | Transmembrane pH-gradient polymer vesicles for quantification of ammonia in body fluids |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006000764A1 (en) * | 2004-06-24 | 2006-01-05 | University College Cardiff Consultants Limited | Ph sensor |
| US9394410B1 (en) * | 2015-04-16 | 2016-07-19 | Carefusion 303, Inc. | Irradiation and post-cure processing of elastomers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998517A (en) * | 1998-06-05 | 1999-12-07 | Becton, Dickinson And Company | Composition for the detection of microorganisms in a sample |
| US20050038183A1 (en) * | 2003-08-14 | 2005-02-17 | Dongchan Ahn | Silicones having improved surface properties and curable silicone compositions for preparing the silicones |
| RU2401846C2 (en) * | 2006-04-25 | 2010-10-20 | Учреждение Российской академии наук Институт синтетических полимерных материалов им. Н.С. Ениколопова РАН (ИСПМ РАН) | Functional polyorganosiloxanes and curable composition based on said polyorganosiloxanes |
| ES2391441T3 (en) * | 2009-12-18 | 2012-11-26 | Dentsply Ih Ab | Medical device for use for a short time with rapidly releasing antibacterial agent |
| US8257827B1 (en) * | 2011-06-02 | 2012-09-04 | The Regents Of The University Of California | Silicone composition and devices incorporating same |
| CN104761697B (en) * | 2014-01-02 | 2017-12-26 | 上海移宇科技股份有限公司 | The film layer and preparation method of a kind of biology sensor |
| CN108132243B (en) * | 2016-12-01 | 2021-07-16 | 中国科学院大连化学物理研究所 | Preparation method and application of ammonia gas on-line rapid detection sensor |
| US10890570B2 (en) * | 2017-11-29 | 2021-01-12 | Michigan Technological University | Gas measurement device |
| CN109632890B (en) * | 2018-11-12 | 2021-07-30 | 中国科学院宁波材料技术与工程研究所 | Preparation method of PAA/AgNPs composite flexible ammonia gas sensor |
-
2019
- 2019-11-14 GB GB2000850.4A patent/GB2594235A/en active Pending
- 2019-11-14 JP JP2020519320A patent/JP2022510519A/en active Pending
- 2019-11-14 WO PCT/GB2019/053224 patent/WO2021094702A1/en active Application Filing
- 2019-11-14 CN CN201980004587.4A patent/CN113133318A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006000764A1 (en) * | 2004-06-24 | 2006-01-05 | University College Cardiff Consultants Limited | Ph sensor |
| US9394410B1 (en) * | 2015-04-16 | 2016-07-19 | Carefusion 303, Inc. | Irradiation and post-cure processing of elastomers |
Non-Patent Citations (1)
| Title |
|---|
| SLADJANA MALIC ET AL: "Development of an "early warning" sensore for encrustation of urinary catheters following Proteus infection", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B: APPLIED BIOMATERIALS, vol. 100B, no 1, 27 September 2011 (2011-09-27), pages 133-137, * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB202000850D0 (en) | 2020-03-04 |
| JP2022510519A (en) | 2022-01-27 |
| CN113133318A (en) | 2021-07-16 |
| WO2021094702A1 (en) | 2021-05-20 |
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