GB2552853B - Purification of Annexin A5 from a composition that includes a calcium ion chelator - Google Patents

Purification of Annexin A5 from a composition that includes a calcium ion chelator

Info

Publication number
GB2552853B
GB2552853B GB1700978.8A GB201700978A GB2552853B GB 2552853 B GB2552853 B GB 2552853B GB 201700978 A GB201700978 A GB 201700978A GB 2552853 B GB2552853 B GB 2552853B
Authority
GB
United Kingdom
Prior art keywords
annexin
purification
composition
calcium ion
ion chelator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1700978.8A
Other versions
GB201700978D0 (en
GB2552853A (en
Inventor
Moks Toomas
Christoph Reich Jan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Annexin Pharmaceuticals AB
Original Assignee
Annexin Pharmaceuticals AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Annexin Pharmaceuticals AB filed Critical Annexin Pharmaceuticals AB
Priority to GB1700978.8A priority Critical patent/GB2552853B/en
Priority claimed from GB1516516.0A external-priority patent/GB2542391A/en
Publication of GB201700978D0 publication Critical patent/GB201700978D0/en
Publication of GB2552853A publication Critical patent/GB2552853A/en
Application granted granted Critical
Publication of GB2552853B publication Critical patent/GB2552853B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
GB1700978.8A 2015-09-17 2015-09-17 Purification of Annexin A5 from a composition that includes a calcium ion chelator Active GB2552853B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1700978.8A GB2552853B (en) 2015-09-17 2015-09-17 Purification of Annexin A5 from a composition that includes a calcium ion chelator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1700978.8A GB2552853B (en) 2015-09-17 2015-09-17 Purification of Annexin A5 from a composition that includes a calcium ion chelator
GB1516516.0A GB2542391A (en) 2015-09-17 2015-09-17 Process of manufacture

Publications (3)

Publication Number Publication Date
GB201700978D0 GB201700978D0 (en) 2017-03-08
GB2552853A GB2552853A (en) 2018-02-14
GB2552853B true GB2552853B (en) 2018-11-21

Family

ID=58462906

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1700978.8A Active GB2552853B (en) 2015-09-17 2015-09-17 Purification of Annexin A5 from a composition that includes a calcium ion chelator

Country Status (1)

Country Link
GB (1) GB2552853B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363176A2 (en) * 1988-10-07 1990-04-11 International Business Machines Corporation Word organised data processors
WO2005099744A1 (en) * 2004-04-15 2005-10-27 Athera Biotechnologies Ab Annexin v for preventing atherothrombois and plaque rupture
WO2011135071A1 (en) * 2010-04-29 2011-11-03 Baxter International Inc. Purification method for divalent cation binding proteins on anion exchange resin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363176A2 (en) * 1988-10-07 1990-04-11 International Business Machines Corporation Word organised data processors
WO2005099744A1 (en) * 2004-04-15 2005-10-27 Athera Biotechnologies Ab Annexin v for preventing atherothrombois and plaque rupture
WO2011135071A1 (en) * 2010-04-29 2011-11-03 Baxter International Inc. Purification method for divalent cation binding proteins on anion exchange resin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biochem. J., Vol 308, 1995, PJ Trotter et al, "Ca2+ concentration during binding determines the manner in which annexin V binds to membranes", 591-8 *
BMC Biotechnology, Vol 14, 2014, LA Marder et al, "Production of recombinant human annexin V by fed-batch cultivation", 33 *
Preparative biochemistry & biotechnology, Vol 30, 2000, LN Zhang et al, "Expression and purification of recombinant human annexin V in Escherichia coli", 305-312 *

Also Published As

Publication number Publication date
GB201700978D0 (en) 2017-03-08
GB2552853A (en) 2018-02-14

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