GB2526542A - Stem cell implanter and absorbable stem cell implant - Google Patents

Stem cell implanter and absorbable stem cell implant Download PDF

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Publication number
GB2526542A
GB2526542A GB1409305.8A GB201409305A GB2526542A GB 2526542 A GB2526542 A GB 2526542A GB 201409305 A GB201409305 A GB 201409305A GB 2526542 A GB2526542 A GB 2526542A
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United Kingdom
Prior art keywords
implant
cavity
cells
stem cell
absorbable
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GB1409305.8A
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GB201409305D0 (en
Inventor
David Anthony Waghorn
Petrus Jacobus Jooste
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Individual
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Individual
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Priority to GB1409305.8A priority Critical patent/GB2526542A/en
Publication of GB201409305D0 publication Critical patent/GB201409305D0/en
Publication of GB2526542A publication Critical patent/GB2526542A/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Prostheses (AREA)

Abstract

A cosmetic surgery implant for insertion into a human body cavity comprising of bio-compatible and bio-absorbable autologous material, in which, the implant is formed to fit the shape and size of the cavity and allow growth and sustainability of the autologous material. The implant will preferably contain other cells with additives where at least one substance may be selected from a group consisting of radioactive markers, antibiotics, haemostatic material, hormone therapies, and cellular precursors. The method of implantation will preferably consist of implanting the implant in a cavity and then expanding the implant within said cavity.

Description

Ste cell Slaflfl *r4, *.sat$*bi.e Ste call.fltaflt ACBAOtJUD OF ThBI INVtNtIQN 1.. fleld 01 th tnvention: The preat ivpt$n r1atas to SapiantabLe dev'ioes M*re: particularly, the pnnit iriventis tel*t63 to lxup]Lantabie bio- *borbAbLt devices designed tii prett rwth bt tissue and eli*irtfl4 reatti.ott to: the implant.
L uescrptiori of the Riated t Thplauta ar used to suppart the integrity af the:bd.y and tn augmentation. ae in t3metid Sit4Ery Autologous fat qrattthg1, or lip*fiu1n4, i beitig incrnsingly used in reconstructive $itrgery, sx as rtsst eto±dtructLon.
tàUwdsxg. cancer. The procedure Smvo yes lwnestiag a atiett s fat i ordet to. intreass the volume of fat. Ja antMr axea oX their body, 2% ptpedxre 1*5 hl4b teserptioa rates of up to 9fl -the percentage of the tranferre4 fat that does:net survive.
rat rafts that have beon:etxiched with c1ture-ezpandd adi,pc.se fat)-4eflved stem elis (ASGS} MVe been shown te significantly imprive graft sctninl Recent fbst. flddfl1S4 hultan trials using stem-cEll grafts toz te tz'zflive ut4ety thaa ahwn the procedure is safe, reliable and effectim. Nevertheless the inte4ttty Arid SurwivaHitty of transplanted efls are tmcrn1se4 with*ut th4 upprttnq extracellular matrix such n *cizs flcth' orqn traspianvatioA.
?rcsthesfis, such as used in breast augmentation, utilize siLicone ox saline Implants but are complited Zr encapsiAation of the fl4fl and xeaflipt to the oretgn aatrials of gxiflr1l4QD at the mpUnt, Mo*ding1y, the need exists far implants flat gaa a4apt:tqx zeplacaextt of sxnafl as well as larqe amounts of tissue both for regneratien aM augmetttation i tst tissue withot the nfl pt ehauing compllcatfnns iliherent in non-abso able imp tArits.
.d exists r opants iW hJ,ph bepeft41aJ *e&aents S ohemical agents can be insti1i* to enhance the t the 1mpiaztS tissuee
SUMMARY OF THE INVENTION
The inventioh provides absorbable tissue implants. The implants of the inventJon are usefuL for applications includrng, hut Ocu limitea to, regenerat1re and trauma reconsLrucfrton and for cosmetic purposes.
In an embodiment, tire invention povic1es afl implant compr.sing a mesh of b.io-compatib.le arid hioabsorbable material, together with appropriat.e sterns cells.
The present invention is based, at least in part, on the discover1 that adrpose-dor ved regenerative cells are capaule of providing angogenlc support and 1ong-term production of both rascular endothelial cells and adipocytes.
Accoroingly, the present invent ion provides such met Lods as of augmenting fat transfer, e g, autologous fat transfer and / or of. regelterating tissue e. g hpatocyte transplantation.
The present invention furtner provrdes compositlons, methods, anc sstems for using cells derived from blood arid/or tissue that nay be admiited with ihcact tiasue and placed directly into a recipient along with such additives necessary no promote, engender, or support a the..rapetc, structural, or cosmetic benefit Por example, the regenerative cells may be cumbinea with growtn factora and/or cytokines, e g, angiogenic or arteriogenic growth factors and other sri.mulators of cell growth and/or differ.ettlstidtr.
In accordance with yet another aspect of the invention, the regeneratLve cells are placed into the recipient in comb_nation with other cells, tissue. tissue fragments.
The composition may be implafied into the recipient to provide an autologous soft Lssue frller for correct Lon of defects cr deficits or for providing support to damaged struct.urs such as the liver. The composition cray also be aministered tc5 breast regions in connection with breast augmentation procedures and soft tissue defects.
Any feature or combination of features dcscribed herein tte included within: the scope of the present invention provided that the features included in any such combination are not mutually Inconsistent as will be apparent from the context, this specificatio.rx, and the knowledge of one f ordinary skill in the art Additional ad:vant ages and uspects of the present invention are apparent in the following detailed d.escriptiorx,
BRIE.F DESCRIPTION OF ThE DRAWINGS
FIG. 1. A diagram of the irnplanter with deflated absorbable mesh being positioned into the subcutaneous region of the skin FIG, 2. A diagram at the implanter containing stCth delis and other cells with additives, attached to the deflated absorbable mesh in situ, FIG. 3. A diagram of the empty implanter with the epanded absorbable mesh containing transplanted snem celia and other cells with additilres.
FIG 4 A diagram of tthe expanded absorbaole mesh, containing stem cells and other cells wilh additives, in tna subcutaneous region of the slcn with the implanter detached and, removed.
FIG, 5. A diagram of the subcutaneous region of the k'Ir, at a later stage, containirg transplanted stems cells, with the mtsh absorbed and the other 05115 With additIves *u'.sed.
DETAILED DESCRIPTLON OF THE PRtFERHED EJ'4BOD'IMEhIT The present invention provides methods for augmenting stem cel.l transfer using iegcnerative cells and other cells with audit ives and the mplant scafffolotng. Inc pvent,on provides icplanL comprising atsorbable material The terms "bioaegrad&ole" and "absorbable" are used interchangeably to mean capable of oreaking down over t_me, inside a patient's body when placed inside a patients bodv' the absorbable implants of the, invention will degrade oyer tiffle and be removed by the body's natural processes.
An implant has an outer shell, as a balloon, 1 made of h hiosorbablo material woven Itita a mesh, The, outer shell 1 is made entirely of a biosorbahie material, such as polyglyco_ic acid, for example, as set forth below. Over a period of approximately three week.s to sIx moz:it,h:s, the outer shell will dissolve., lsaving' the liner contents of stem cell.s 3 present.
inside the tissue. Hard encapsulation will not occar because there i.s not a foreign body contained withi.n. the implant spaceS.
The outer shell 1 is provided an a mesh or weave of the mixed material, surrounding Contents 3 and 4 as descrhed above After a resorption period contents 3 remain, surrounded by tissue 2 into which the implant is inserted, Accordingly., the stem cells 3 remain after the biosorbajile materrals of the implant 2. resorb, having acted as a scaffoloing to allow the stem cells to integrate into the tissue 2 and hold their shape, because there is no foreign matertal remaining, encapsulation of the implant 1 is prevented tfte imoiar1tatioi, the implant 1 dissolves, thus preverLing hardening by eooapsulation of the implant with th.e tissue.
A further alterhative ethbOdihent cit the present invention includes an implant proviced in the form of a matrix raireo:k, such as a sponge or foam The implant is hiocegradable, has a porous sttucture which supports the surrounding tissue and provides a framework for the in-growth of stems cells with the assistance of the other cells and additives, Accorthng to a prefer red embodiment, the implant is.p.rcwided i the form of a sponge which can be modified by a surgeon prior to implantation, such as simply by trimming tne sponge to the appropriate 5i*ze and ahape or designing by CAD software on a 3D printer Advantageously, tne impfint can be modified to correspond to the I,. issue than either has been removed, i equines replacement, or requires augmentation.
Accordingly a preferred method of £mptantati,pa is shown: in which the sponge is elastically compressible, and can cc deLivered using a small iflcflSiofl in the skin and inserted via the tmpta:nter 5 into the. tissue 2, A single implant 1. is Shown.bei.ng coffipre.pned o as: to fit unde.r the skin 2. Then a force is applied to drive the compressed unpiant into the implart site, here toe resriient sponqo 6 expands to fill tne _mplant site space Advantageously, the implant can be used in conlunot ion with st.ereotactic imaging devises such as ultrasound, As a further alternative, the sponge Implant of the present.
invention can form all or part of a larger implant, Invol vi rig the insertion of several such implants, woich are indvidualiy sized, to fit the desired area to be filled.
Implantation using such procedures would be indicated when the sponge implant of the present invention is used as all or part of a larger implant.
In addition, the implant 6 cat be provided in the forrci of an expanding foam with a more resilient outer capsule made of the same biomaterial, of a denser eave to provide wth a balloon like quality wnen the stem cells and other celis wits additives, e injected by the implanter in a metered amount 5 of FIG.3, Following Lnsertion ci the implant, such as by an open nthod or one ol the stereotactic methods described above, the resorbable implant 6 occupies the tissue area, 2 -inc supports toe surrounding tissue unLil such tmc s-s it is resorbed or biodegrades leaving the stem cells in place 3 After initial implantation, the patient's oa surrounding cells 0nd regenerative proteins permeate the implant together with the l:mplanted cells and additives.
Various biosorhable materials can be used in the implant of t.he present invention.
1nowr brosorbable materials include the following polyqiycolit acid (Dexon Davis & Geck); polyglactin material cvicryl, Ethtcon, pc.li gLecaprone (Monocryl, Ethicot) and synthetic absorbable lactomer 9-i.( Polys.ort., US$0) the examples aboV ate designed Lo last varying lengths qf time.
after which time they ae totally te.scrbed. According to the present invention, these products may he rrixed with one ariotner to provide various resorpt.ion times 0r qradietts.
In eacfr of the embOdtmentt the resothable implant ultimately biodegrade, and the patient is left ditn autologous tissue, some of which has been implanted 3, and some of which has encroacheo :nto tne implanted arte, tens augmenting and regenerating the area.
The present invChti.on has been described particularly in connection with a subcutaneous area of the skin 2, unt it wili be obvious to those ci sbil in the art that the invention can have application to other pait of the body, such as the liver Although the present invention has been described in relation to particular embodiments thereof, many other variations cud modifications and other uses v,ijl become apparent to those skilled in the art It is preferrod, therefore, that the present invention be limited not by the soecific cisclosure herein, hut only by the appended claims.

Claims (3)

  1. CLAIMS (3) What is claimed is: 1. An implant for implantation in a human body for cosmetic purposes comprising entireiy of resorbabie material, the implant being formed to fit the shape and size of a cavity in the human body, containing and supporting autologous materiai and ailowing for the growth and sustainability of that autoiogous material.
  2. 2. The implant of olaim 1, further containing other cells with additives wherein at least one substance is seiected from the group oonsisting of radiographio markers, antibiotics, haemostatic material, hormone therapies and celiuiar precursors.
  3. 3. The method of impiantation of ciaim 1, wherein the step of implanting the implant in the cavity oomprises expanding the impiant within the cavity. r
GB1409305.8A 2014-05-26 2014-05-26 Stem cell implanter and absorbable stem cell implant Withdrawn GB2526542A (en)

Priority Applications (1)

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GB1409305.8A GB2526542A (en) 2014-05-26 2014-05-26 Stem cell implanter and absorbable stem cell implant

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GB1409305.8A GB2526542A (en) 2014-05-26 2014-05-26 Stem cell implanter and absorbable stem cell implant

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GB201409305D0 GB201409305D0 (en) 2014-07-09
GB2526542A true GB2526542A (en) 2015-12-02

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157085A (en) * 1978-03-24 1979-06-05 Dow Corning Corporation Surgically implantable tissue expanding device and the method of its use
WO1996018424A1 (en) * 1994-12-16 1996-06-20 Children's Medical Center Corporation Breast tissue engineering
US20010041936A1 (en) * 1997-10-10 2001-11-15 Corbitt John D. Bioabsorbable breast implant
EP1216718A1 (en) * 2000-12-21 2002-06-26 Ethicon, Inc. Reinforced foam implants for soft tissue repair and regeneration
WO2006023803A2 (en) * 2004-08-20 2006-03-02 Artes Medical, Inc. Methods of administering microparticles combined with autologous body components
US20060058735A1 (en) * 2004-09-16 2006-03-16 Lesh Michael D Systems and devices for soft tissue augmentation
GB2426452A (en) * 2005-05-26 2006-11-29 Intercytex Ltd Tissue Repair and Augmentation
US20070104694A1 (en) * 2005-11-07 2007-05-10 Quijano Rodolfo C Breast stimulation and augmentation system
WO2008014283A2 (en) * 2006-07-24 2008-01-31 Novalert, Inc. Method and apparatus for minimally invasive implants
WO2010003104A2 (en) * 2008-07-02 2010-01-07 Allergan, Inc. Compositions and methods for tissue filling and regeneration
WO2010109226A2 (en) * 2009-03-23 2010-09-30 University Of Leeds Scaffold
WO2011003422A1 (en) * 2009-07-06 2011-01-13 Coloplast A/S Biodegradable scaffold for soft tissue regeneration and use thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157085A (en) * 1978-03-24 1979-06-05 Dow Corning Corporation Surgically implantable tissue expanding device and the method of its use
WO1996018424A1 (en) * 1994-12-16 1996-06-20 Children's Medical Center Corporation Breast tissue engineering
US20010041936A1 (en) * 1997-10-10 2001-11-15 Corbitt John D. Bioabsorbable breast implant
EP1216718A1 (en) * 2000-12-21 2002-06-26 Ethicon, Inc. Reinforced foam implants for soft tissue repair and regeneration
WO2006023803A2 (en) * 2004-08-20 2006-03-02 Artes Medical, Inc. Methods of administering microparticles combined with autologous body components
US20060058735A1 (en) * 2004-09-16 2006-03-16 Lesh Michael D Systems and devices for soft tissue augmentation
GB2426452A (en) * 2005-05-26 2006-11-29 Intercytex Ltd Tissue Repair and Augmentation
US20070104694A1 (en) * 2005-11-07 2007-05-10 Quijano Rodolfo C Breast stimulation and augmentation system
WO2008014283A2 (en) * 2006-07-24 2008-01-31 Novalert, Inc. Method and apparatus for minimally invasive implants
WO2010003104A2 (en) * 2008-07-02 2010-01-07 Allergan, Inc. Compositions and methods for tissue filling and regeneration
WO2010109226A2 (en) * 2009-03-23 2010-09-30 University Of Leeds Scaffold
WO2011003422A1 (en) * 2009-07-06 2011-01-13 Coloplast A/S Biodegradable scaffold for soft tissue regeneration and use thereof

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Publication number Publication date
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