GB2494741B - A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery - Google Patents
A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discoveryInfo
- Publication number
- GB2494741B GB2494741B GB201211395A GB201211395A GB2494741B GB 2494741 B GB2494741 B GB 2494741B GB 201211395 A GB201211395 A GB 201211395A GB 201211395 A GB201211395 A GB 201211395A GB 2494741 B GB2494741 B GB 2494741B
- Authority
- GB
- United Kingdom
- Prior art keywords
- gene expression
- colorectal cancer
- prognosis
- crc
- diagnosing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
Abstract
The invention relates to a method of detecting autoantibodies related to colorectal cancer in an individual comprising contacting a test sample from an individual with one or more target antigens selected from MAP4K4 and IGFBP3 and detecting any antibodies that bind to said antigens. The sample may also be contacted with target antigens selected from p53 or IGF2BP2 to detect autoantibodies to said antigens. Also provided in a further embodiment is a method for identifying antibodies related to cancer by comparing gene expression levels of cancer cells compared to normal cells, assaying body fluid from an individual with cancer for antibodies to the genes only activated in the cancer cells and identifying an antibody.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161501466P | 2011-06-27 | 2011-06-27 | |
US13/533,036 US20130022987A1 (en) | 2011-06-27 | 2012-06-26 | Method for Diagnosing or Determining the Prognosis of Colorectal Cancer (CRC) Using Novel Autoantigens: Gene Expression Guided Autoantigen Discovery |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201211395D0 GB201211395D0 (en) | 2012-08-08 |
GB2494741A GB2494741A (en) | 2013-03-20 |
GB2494741B true GB2494741B (en) | 2013-11-06 |
Family
ID=46704290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB201211395A Expired - Fee Related GB2494741B (en) | 2011-06-27 | 2012-06-27 | A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2494741B (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009114836A1 (en) * | 2008-03-14 | 2009-09-17 | Genomic Health, Inc. | Gene expression markers for prediction of patient response to chemotherapy |
WO2010042228A2 (en) * | 2008-10-10 | 2010-04-15 | Cornell University | Methods for predicting disease outcome in patients with colon cancer |
US20100297014A1 (en) * | 2007-10-10 | 2010-11-25 | Paul Jenkins | Method of detecting the risk of cancer using genetic markers |
-
2012
- 2012-06-27 GB GB201211395A patent/GB2494741B/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100297014A1 (en) * | 2007-10-10 | 2010-11-25 | Paul Jenkins | Method of detecting the risk of cancer using genetic markers |
WO2009114836A1 (en) * | 2008-03-14 | 2009-09-17 | Genomic Health, Inc. | Gene expression markers for prediction of patient response to chemotherapy |
WO2010042228A2 (en) * | 2008-10-10 | 2010-04-15 | Cornell University | Methods for predicting disease outcome in patients with colon cancer |
Non-Patent Citations (6)
Also Published As
Publication number | Publication date |
---|---|
GB2494741A (en) | 2013-03-20 |
GB201211395D0 (en) | 2012-08-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20230393150A1 (en) | Methods and algorithms for aiding in the detection of cancer | |
Norman et al. | Anti‐kelch‐like 12 and anti‐hexokinase 1: novel autoantibodies in primary biliary cirrhosis | |
Zhou et al. | Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery | |
WO2012061759A3 (en) | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers | |
Chang et al. | Secretome-based identification of ULBP2 as a novel serum marker for pancreatic cancer detection | |
NZ706187A (en) | Assays for the detection of anti-tnf drugs and autoantibodies | |
NZ593514A (en) | p-mTOR and p-AKT as Ratio Based Biomarkers for the Prognosis and/or Diagnosis of Cancer | |
WO2014144129A3 (en) | Biomarkers and methods for predicting preterm birth | |
IN2015DN01855A (en) | ||
EA201370063A1 (en) | PHOSPHOLYPIDE CANCER | |
MX2014001377A (en) | Method for detecting pancreatic cancer. | |
MX2009008307A (en) | Methods and materials for identifying the origin of a carcinoma of unknown primary origin. | |
MX2019006098A (en) | Antibody assay. | |
Ding et al. | Circulating tumor cell levels and carcinoembryonic antigen: An improved diagnostic method for lung adenocarcinoma | |
RU2012148711A (en) | METHOD AND KIT FOR DIAGNOSIS OF A MALIGNANT TUMOR | |
WO2009121024A3 (en) | Methods for detecting antibodies | |
Rosser et al. | Urinary biomarkers of bladder cancer: an update and future perspectives | |
JP2017509351A5 (en) | ||
Wang et al. | Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance | |
RU2019104870A (en) | COMBINED TEST FOR THE PRESENCE OF COLORECTAL CANCER | |
Chiam et al. | Identification of microRNA biomarkers of response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma using next generation sequencing | |
Roney et al. | IgM and IgA augmented autoantibody signatures improve early‐stage detection of colorectal cancer prior to nodal and distant spread | |
EP2415877A3 (en) | Means and methods for diagnosing pancreatic cancer | |
WO2019089858A3 (en) | Methods of assessing or monitoring a response to a cell therapy | |
GB2494741B (en) | A method for diagnosing or determining the prognosis of colorectal cancer (crc) using novel autoantigens: gene expression guided autoantigen discovery |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20160627 |