GB2459910B - Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders - Google Patents
Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic DisordersInfo
- Publication number
- GB2459910B GB2459910B GB0823378A GB0823378A GB2459910B GB 2459910 B GB2459910 B GB 2459910B GB 0823378 A GB0823378 A GB 0823378A GB 0823378 A GB0823378 A GB 0823378A GB 2459910 B GB2459910 B GB 2459910B
- Authority
- GB
- United Kingdom
- Prior art keywords
- treatment
- methods
- controlled release
- otic disorders
- corticosteroid compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Priority Applications (30)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0912650A GB2461186B (en) | 2008-04-21 | 2008-12-22 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
RU2010150863/15A RU2469726C2 (en) | 2008-05-14 | 2009-05-14 | Corticosteroid-based composition with controlled release for treatment of ear diseases |
JP2011509498A JP5551685B2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods of treating otic disorders |
KR1020137021389A KR101534422B1 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
MX2010012397A MX2010012397A (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders. |
EP09747010.8A EP2303227B1 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
CA2723458A CA2723458C (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
AU2009246870A AU2009246870B2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
PCT/US2009/003066 WO2009139924A2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
CN200980116869XA CN102026623B (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
CN201310289183.9A CN103417472B (en) | 2008-05-14 | 2009-05-14 | For treating the control release corticosteroid composition and method of otic conditions |
MYPI2010005337A MY161021A (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid and methods for the treatment of otic disorders |
KR1020107026567A KR101477329B1 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
BRPI0912482-9A BRPI0912482A2 (en) | 2008-05-14 | 2009-05-14 | controlled-release corticosteroid compositions and methods for the treatment of atrial disorders |
US12/466,310 US8030297B2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of OTIC disorders |
US12/837,286 US8546363B2 (en) | 2008-05-14 | 2010-07-15 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
IL208806A IL208806A (en) | 2008-05-14 | 2010-10-19 | Controlled release corticosteroid compositions and their use in the treatment of otic disorders |
ZA2010/07482A ZA201007482B (en) | 2008-05-14 | 2010-10-20 | Controlled release corticosteriod compositions and methods for the treatment of otic disorders |
US13/190,327 US8658626B2 (en) | 2008-05-14 | 2011-07-25 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
US13/190,323 US8680082B2 (en) | 2008-05-14 | 2011-07-25 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
US13/190,330 US8828980B2 (en) | 2008-05-14 | 2011-07-25 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
US13/190,329 US8680083B2 (en) | 2008-05-14 | 2011-07-25 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
HK11110956.8A HK1156533A1 (en) | 2008-05-14 | 2011-10-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
RU2012139802/15A RU2012139802A (en) | 2008-05-14 | 2012-09-18 | COMPOSITIONS WITH CONTROLLED RELEASE ON THE BASIS OF CORTICOSTEROIDS FOR THE TREATMENT OF EAR DISEASES |
JP2014049354A JP6014069B2 (en) | 2008-05-14 | 2014-03-12 | Controlled release corticosteroid compositions and methods of treating otic disorders |
US14/300,030 US9744126B2 (en) | 2008-05-14 | 2014-06-09 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
US14/795,819 US9511020B2 (en) | 2008-05-14 | 2015-07-09 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
IL244103A IL244103A0 (en) | 2008-05-14 | 2016-02-14 | Controlled release corticosteroid compositions and their use in the treatment of otic disorders |
JP2016094870A JP2016153423A (en) | 2008-05-14 | 2016-05-10 | Controlled release corticosteroid compositions and methods for treatment of otic disorders |
US15/612,701 US20180110727A1 (en) | 2008-05-14 | 2017-06-02 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4654308P | 2008-04-21 | 2008-04-21 | |
US12771308P | 2008-05-14 | 2008-05-14 | |
US8794008P | 2008-08-11 | 2008-08-11 | |
US9524808P | 2008-09-08 | 2008-09-08 | |
GB0912650A GB2461186B (en) | 2008-04-21 | 2008-12-22 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
GB0823378D0 GB0823378D0 (en) | 2009-01-28 |
GB2459910A GB2459910A (en) | 2009-11-11 |
GB2459910B true GB2459910B (en) | 2010-03-31 |
Family
ID=40344056
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0823378A Expired - Fee Related GB2459910B (en) | 2008-04-21 | 2008-12-22 | Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders |
GB0912650A Expired - Fee Related GB2461186B (en) | 2008-04-21 | 2008-12-22 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0912650A Expired - Fee Related GB2461186B (en) | 2008-04-21 | 2008-12-22 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Country Status (1)
Country | Link |
---|---|
GB (2) | GB2459910B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2461962B (en) * | 2008-07-25 | 2011-02-16 | Otonomy Inc | Slow release NMDA receptor antagonist for otic disorders |
US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
WO2013130619A1 (en) | 2012-02-27 | 2013-09-06 | O-Ray Pharma, Inc. | Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders |
WO2014039781A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
CN105705141B (en) * | 2013-03-15 | 2018-12-28 | 奥克伍德实验室有限责任公司 | Sustained-release micro-spheres and preparation method thereof |
EP3370698B1 (en) * | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Sol-gel polymer composites and uses thereof |
US20200214976A1 (en) * | 2019-01-09 | 2020-07-09 | Spiral Therapeutics, Inc. | Self-gelling solutions for administration of therapeutics to the inner ear |
CN110128467A (en) * | 2019-05-07 | 2019-08-16 | 天津康巢生物医药股份有限公司 | A kind of process of purification of glycerol phosphatidyl choline crude product and its obtained glycerolphosphocholine |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003071986A2 (en) * | 2002-02-22 | 2003-09-04 | Control Delivery Systems, Inc. | Method for treating otic disorders |
US20060046970A1 (en) * | 2004-08-31 | 2006-03-02 | Insite Vision Incorporated | Topical otic compositions and methods of topical treatment of prevention of otic infections |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060013858A1 (en) * | 2002-10-29 | 2006-01-19 | Trune Dennis R | Fludrocortisone treatment for hearing loss |
-
2008
- 2008-12-22 GB GB0823378A patent/GB2459910B/en not_active Expired - Fee Related
- 2008-12-22 GB GB0912650A patent/GB2461186B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003071986A2 (en) * | 2002-02-22 | 2003-09-04 | Control Delivery Systems, Inc. | Method for treating otic disorders |
US20060046970A1 (en) * | 2004-08-31 | 2006-03-02 | Insite Vision Incorporated | Topical otic compositions and methods of topical treatment of prevention of otic infections |
Non-Patent Citations (4)
Title |
---|
Biomaterials; Vol 26, pp 3311-3318 (2005). Fernandez et al. "Self-curing controlled release systems for steroids...." * |
Lin chuang er bi yan hou tou jing wai ke za zhi; Vol 22, pp 28-31 (January 2008). Feng et al. "In vitro and in vivo biodegradation of sustained-release vehicle poloxamer 407 in situ gel". Medline Accession Number NLM18338567 * |
The Laryngoscope; Vol 118, pp 706-711 (2008). Paulson et al. "A novel controlled local drug delivery system for inner ear disease" * |
Xhonghua yi xue za zhi; Vol 87, pp 2289-2297 (2007). Feng et al. "Effect of poloxamer 407 on the cochlear morphology and hearing function after perfusion in round window....". Medline Accession Number NLM18001555 * |
Also Published As
Publication number | Publication date |
---|---|
GB0912650D0 (en) | 2009-08-26 |
GB2461186B (en) | 2010-09-01 |
GB2461186A (en) | 2009-12-30 |
GB2459910A (en) | 2009-11-11 |
GB0823378D0 (en) | 2009-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20201222 |