GB2451452A - A lubricant formulation - Google Patents
A lubricant formulation Download PDFInfo
- Publication number
- GB2451452A GB2451452A GB0714794A GB0714794A GB2451452A GB 2451452 A GB2451452 A GB 2451452A GB 0714794 A GB0714794 A GB 0714794A GB 0714794 A GB0714794 A GB 0714794A GB 2451452 A GB2451452 A GB 2451452A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- lubricant formulation
- sodium
- formulation according
- lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000314 lubricant Substances 0.000 title claims abstract description 53
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 238000009472 formulation Methods 0.000 title claims abstract description 35
- 239000003974 emollient agent Substances 0.000 claims abstract description 15
- 239000003429 antifungal agent Substances 0.000 claims abstract description 14
- 229940121375 antifungal agent Drugs 0.000 claims abstract description 14
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract description 8
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000005461 lubrication Methods 0.000 claims abstract description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical group [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 7
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000000907 Condylomata Acuminata Diseases 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 description 1
- 201000004201 anogenital venereal wart Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001150 spermicidal effect Effects 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
A lubricant formulation comprises polyethylene oxide for providing the lubrication, at least one emollient, at least one bacteriacide, at least one emulsifier, at least one antifungal agent, and dionised water. The emollient may be isopropyl myristste, the bacteriocide may be chlorhexidine digluconate and the antifungal agent may be sodium methylparabens.
Description
* 1 2451452
A LUBRICANT FORMULATION
This invention relates to a lubricant formulation. The lubricant formulation may be used for any suitable and appropriate use. The lubricant formulation may be especially useful for reducing frictional forces in human and veterinary applications. The lubricant may also be especially useful for hygiene purposes.
Lubricant formulations are well known. The known lubricant formulations may be used for reducing frictional forces in human and veterinary applications such for example as in ultrasound scanning, birth processes and parasite control. The use of lubricants is also well known for sexual purposes.
The known lubricants include various agents to provide desired results.
For example, the known lubricants may include agents providing antiseptic, antibacterial and spermicidal properties designed to reduce the risk of infection during use. The lubricants may be used by humans or they may be used on animals. The lubricants may include a cooling agent such for example as menthol, or a colouring agent for providing a desired aesthetic effect.
There are various problems associated with the production of the lubricants. These problems ensure including that the lubricant has a suitable texture, that the lubricant has a viscosity acceptable to the user, that the appearance of the lubricant is aesthetically pleasing, and that the lubricant is stable so that it does not degrade andlor dry out prematurely with time. For example, the small pH of a female human vagina is generally acidic and many known lubricants become ineffective in such an acidic environment.
The viscosity of a lubricant is of especial importance to the efficacy of any antiseptic and/or antimicrobial agents contained therein. Thin and low viscosity lubricants often do not maintain adequate coverage on the surfaces onto which they are placed. This can result in reduced lubrication and reduced antiseptic andlor antimicrobial protection in vulnerable areas. This problem is also shared by lubricants which have a tendency to dry out prematurely over time.
It is an aim of the present invention to reduce the above mentioned problems.
Accordingly, in one non-limiting embodiment of the present invention there is provided a lubricant formulation, which lubricant formulation comprises polyethylene oxide for providing the lubrication, at least one emollient, at least one bacteriacide, at least one emulsifier, at least one antifungal agent, and dionised water.
The lubricant formulation of the present invention may be such that it does not prematurely get absorbed into human or animal skin, nor prematurely dry out. The lubricant formulation of the present invention may be able to maintain its lubricity for over ten hours. The presence of the bacterlacide and the antifungal agent is advantageous in helping to reduce the risk of transmitted infections. Thus, for example, the lubricant formulation may provide barrier protection against the spread of infections, for example HIV. The lubricant formulation may also be able to prevent damage to tissue, for example by lubricating surfaces that might otherwise become uncomfortable or damaged due to too much friction. The lubricant formulation may be useful medically and hygienically in preventing the transmission during intercourse of sexually transmitted infections such for example as genital warts, herpes simplex, HIV, gonorrhoea and syphilis. The lubricant formulation of the present invention does not become ineffective in acidic environments found in the female human vagina.
The lubricant formation may be one in which there are two of the emollients. Preferably, the two emollients are monopropylene glycol and isopropyl miristate. Other emollients may be employed. Also, a single emollient or more than two emollients may be employed.
The bacteriacide is preferably chlorhexidine digluconate. Other bactenacides may be employed, for example other chlorhexidine based bacteriacides.
The emulsifier is preferably sodium polyacrylate hydrogenated polydecene trideceth-6. Other emulsiflers may be employed. The emulsifiers should be such that they are compatible with the remainder of the ingredients of the lubricant formulation.
Preferably, there are two of the antifungal agents. Preferably, the two antifungal agents are sodium methylparabens and sodium proplylparabens.
Other antifungal agents may be employed.
Preferably, the lubricant formulation of the present invention comprises: (i) 0.5-3% by weight polyethylene oxide, (ii) 5-20% by weight monopropylene glycol as an emollient, (iii) 5-20% by weight isopropyl minstate as an emollient, (iv) 0.1-1.0% by weight chiorhexidine digluconate as a bacteriacide, (v) 0.1-1.5% by weight sodium polyacrylate hydrogenated polydecene trideceth-6 as an emulsifier, (vi) 0.05-0.2% by weight sodium methylparabens as an antifungal agent, (vii) 0.05-0.1% by weight sodium propylparabens as an antifungal agent, and (viii) 50-85% by weight dionised water.
Preferably, the lubricant formulation of the present invention comprises: (i) 1% by weight of the polyethylene oxide, (ii) 10% by weight of the monopropylene glycol, (iii) 10% by weight of the isopropyl miristate, (iv) 0.25% by weight of the chiorhexidine digluconate, (v) 1. 0% by weight of the sodium polyacrylate hydrogenated polydecene tndeceth-6, (vi) 0.15% by weight of the sodium methylparabens, (vii) 0.05% by weight of the sodium propylparabens, and (viii) 77.55% by weight dionised water.
The invention will now be described with reference to the accompanying Example.
EXAMPLE
A lubricant formulation was prepared. The lubricant formulation was for personal use during sexual activity. The lubricant formulation had a composition comprising: (I) 1% by weight of the polyethylene oxide, (ii) 10% by weight of the monopropylene glycol, (iii) 10% by weight of the isopropyl miristate, (iv) 0.25% by weight of the chlorhexidine digluconate, (v) 1.0% by weight of the sodium polyacrylate hydrogenated polydecene tndeceth-6, (vi) 0.15% by weight of the sodium methylparabens, (vii) 0.05% by weight of the sodium propylparabens, and (viii) 77.55% by weight dionised water.
The lubricant formation was tested on a person's skin. It was found that the lubricant formation did not prematurely get absorbed into the person's skin, nor prematurely dry out. It was found that the lubricant formulation was able to maintain its lubricity for over ten hours. The lubricant formulation formed a barrier available for helping to prevent the spread of infections.
Claims (10)
1. A lubricant formulation, which lubricant formulation comprises polyethylene oxide for providing the lubrication, at least one emollient, at least one bacteriacide, at least one emulsifier, at least one antifungal agent, and dionised water.
2. A lubricant formulation according to claim i in which there are two of the emollients.
3. A lubricant formulation according to claim 2 in which the two emollients are monopropylene glycol and isopropyl miristate.
4. A lubricant formulation according to any one of the preceding claims in which the bacteriacide is chlorhexidine digluconate.
5. A lubricant formulation according to any one of the preceding claims in which the emulsifier is sodium polyacrylate hydrogenated polydecene tndeceth-6.
6. A lubricant formulation according to any one of the preceding claims in which there are two of the antifungal agents.
7. A lubricant formulation according to claim 6 in which the two antifungal agents are sodium methylparabens and sodium proplylparabens.
8. A lubricant formulation according to claim I and comprising: (i) 0.5-3% by weight polyethylene oxide, (ii) 5-20% by weight monopropylene glycol as an emollient, (iii) 5-20% by weight isopropyl miristate as an emollient, (iv) 0.1-1.5% by weight chiorhexidine digluconate as a bacteriacide, (v) 0.1-1.0% by weight sodium polyacrylate hydrogenated polydecene trideceth-6 as an emulsifier, (vi) 0.05-0.2% by weight sodium methylparabens as an antifungal agent, (vii) 0.05-0.1% by weight sodium propylparabens as an antifungal agent, and (viii) 50-85% by weight dionised water.
9. A lubricant formulation according to claim B and comprising: (I) 1% by weight of the polyethylene oxide, (ii) 10% by weight of the monopropylene glyco, (iii) 10% by weight of the isopropyl miristate, (iv) 0.25% by weight of the chlorhexidine digluconate, (v) 1.0% by weight of the sodium polyacrylate hydrogenated polydecene trideceth-6, (vi) 0.15% by weight of the sodium methylparabens, (vii) 0.05% by weight of the sodium propylparabeflS and (viii) 77.55% by weight dionised water.
10. A lubricant formulation according to claim I and substantially as herein described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0714794A GB2451452A (en) | 2007-07-30 | 2007-07-30 | A lubricant formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0714794A GB2451452A (en) | 2007-07-30 | 2007-07-30 | A lubricant formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0714794D0 GB0714794D0 (en) | 2007-09-12 |
| GB2451452A true GB2451452A (en) | 2009-02-04 |
Family
ID=38528967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0714794A Withdrawn GB2451452A (en) | 2007-07-30 | 2007-07-30 | A lubricant formulation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2451452A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992009256A1 (en) * | 1990-12-03 | 1992-06-11 | Medical Polymers, Inc. | Water-based human tissue lubricant |
| GB2351736A (en) * | 1999-07-01 | 2001-01-10 | Sonotech Inc | Biocompatible ultrasound couplant and medical apparatus lubricant |
| WO2003066001A2 (en) * | 2002-02-07 | 2003-08-14 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
| US20040138074A1 (en) * | 2002-05-01 | 2004-07-15 | Nawaz Ahmad | Warming and nonirritating lubricant compositions and method of comparing irritation |
| US20050058693A1 (en) * | 2003-09-11 | 2005-03-17 | Kimberly-Clark Worldwide, Inc. | Tissue products comprising a moisturizing and lubricating composition |
| WO2006004577A2 (en) * | 2004-03-12 | 2006-01-12 | Melbj Holdings, Llc | Lubricant for the ocular surface |
| WO2008045696A2 (en) * | 2006-10-10 | 2008-04-17 | Laclede, Inc. | Methods and compositions for the treatment of vaginal diseases employing peroxide-producing enzymes and peroxidases |
-
2007
- 2007-07-30 GB GB0714794A patent/GB2451452A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992009256A1 (en) * | 1990-12-03 | 1992-06-11 | Medical Polymers, Inc. | Water-based human tissue lubricant |
| GB2351736A (en) * | 1999-07-01 | 2001-01-10 | Sonotech Inc | Biocompatible ultrasound couplant and medical apparatus lubricant |
| WO2003066001A2 (en) * | 2002-02-07 | 2003-08-14 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
| US20040138074A1 (en) * | 2002-05-01 | 2004-07-15 | Nawaz Ahmad | Warming and nonirritating lubricant compositions and method of comparing irritation |
| US20050058693A1 (en) * | 2003-09-11 | 2005-03-17 | Kimberly-Clark Worldwide, Inc. | Tissue products comprising a moisturizing and lubricating composition |
| WO2006004577A2 (en) * | 2004-03-12 | 2006-01-12 | Melbj Holdings, Llc | Lubricant for the ocular surface |
| WO2008045696A2 (en) * | 2006-10-10 | 2008-04-17 | Laclede, Inc. | Methods and compositions for the treatment of vaginal diseases employing peroxide-producing enzymes and peroxidases |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0714794D0 (en) | 2007-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2003216213B2 (en) | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides | |
| ES2308045T3 (en) | FUNGICIDE COMPOSITIONS, HEATING LUBRICANTS AND NON-IRRITANTS IN THE FORM OF A GEL. | |
| JP2015178497A (en) | Semi-fluid composition used for lubrication, moisturization, disinfection or sterilization, and method of use thereof | |
| AU5377096A (en) | Fast acting and persistent topical antiseptic | |
| US20030211173A1 (en) | Lubrication composition | |
| US11806325B2 (en) | Topical fertility promoting product and manufacturing method | |
| ES2719847T3 (en) | Antiseptic composition | |
| MX2007010231A (en) | Thickened spreadable warming lubricant. | |
| EP1467743B1 (en) | Pharmaceutical combinations comprising a fungicide, a bacteriostatic sulphonamide and an antibacterial compound for topical application | |
| US8518434B2 (en) | Antiseptic spermicidal composition and means for its application | |
| MXPA06001411A (en) | Topical veterinary compositions and methods for the treatment and prevention of infection. | |
| JP2005529901A (en) | Warming and non-irritating lubricant antifungal gel composition | |
| ES2524062T3 (en) | Topical formulations for the prevention of sexually transmitted diseases and methods to produce them | |
| KR20150018636A (en) | Compositions and methods for enhancing the efficacy of contraceptive microbicides | |
| GB2451452A (en) | A lubricant formulation | |
| US9855205B2 (en) | Use of zinc coceth sulfate as an antibacterial agent against propionibacterium acnes | |
| EP1638516B1 (en) | Barrier formulation comprising a silicone based emulsion | |
| US7687078B1 (en) | Method of treatment | |
| CA2795977A1 (en) | Method of treatment | |
| US20080081797A1 (en) | Topical formulations for the prevention of sexually transmitted disease and methods of producing the same | |
| CA2132688A1 (en) | Anti-septic, spermicidal composition and means for its application | |
| WO2000072839A1 (en) | Antiseptic spermicidal composition and means for its application | |
| US20190083428A1 (en) | Salt balanced vaginal product and method | |
| ES2523938T3 (en) | Topical formulations for the prevention of a sexually transmitted disease and methods to produce them | |
| US20180185411A1 (en) | Topical vaginal composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |