GB2450443A - Improvements in and relating to analysis of mixed source dna profiles - Google Patents

Improvements in and relating to analysis of mixed source dna profiles Download PDF

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Publication number
GB2450443A
GB2450443A GB0818032A GB0818032A GB2450443A GB 2450443 A GB2450443 A GB 2450443A GB 0818032 A GB0818032 A GB 0818032A GB 0818032 A GB0818032 A GB 0818032A GB 2450443 A GB2450443 A GB 2450443A
Authority
GB
United Kingdom
Prior art keywords
value set
selected value
dna
relating
result
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0818032A
Other versions
GB0818032D0 (en
Inventor
James Curran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forensic Science Service Ltd
Original Assignee
Forensic Science Service Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forensic Science Service Ltd filed Critical Forensic Science Service Ltd
Priority claimed from PCT/GB2007/001125 external-priority patent/WO2007113490A1/en
Publication of GB0818032D0 publication Critical patent/GB0818032D0/en
Publication of GB2450443A publication Critical patent/GB2450443A/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of analysing DNA samples from mixed sources, the method including i) obtaining an observed result relating to a value set for a characteristic of the DNA; ii) randomly selecting a selected value set for that DNA characteristic and generating an expected result from that selected value set; iii) comparing the observed result and the expected result and quantifying the difference there between; iv) considering the selected value set to be the optimal match; v) randomly selecting a different selected value set and generating another expected result from that selected value set; vi) comparing the observed result with the another expected result and quantifying the difference there between; vii) replacing the existing optimal value set with the different selected value set of step v) if a criteria is met; viii) repeating steps v), vi) and vii) at least 10 times; ix) the last optimal match being taken to be the optimal match for the value set for the DNA.
GB0818032A 2007-03-28 2007-03-28 Improvements in and relating to analysis of mixed source dna profiles Withdrawn GB2450443A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2007/001125 WO2007113490A1 (en) 2006-04-03 2007-03-28 Improvements in and relating to analysis of mixed source dna profiles

Publications (2)

Publication Number Publication Date
GB0818032D0 GB0818032D0 (en) 2008-11-05
GB2450443A true GB2450443A (en) 2008-12-24

Family

ID=40028887

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0818032A Withdrawn GB2450443A (en) 2007-03-28 2007-03-28 Improvements in and relating to analysis of mixed source dna profiles

Country Status (1)

Country Link
GB (1) GB2450443A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876933A (en) * 1994-09-29 1999-03-02 Perlin; Mark W. Method and system for genotyping
US20020152035A1 (en) * 2001-02-02 2002-10-17 Perlin Mark W. Method and system for DNA mixture analysis
US20050282197A1 (en) * 2001-12-21 2005-12-22 The Secretary Of State For The Home Department Interpreting DNA

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876933A (en) * 1994-09-29 1999-03-02 Perlin; Mark W. Method and system for genotyping
US20020152035A1 (en) * 2001-02-02 2002-10-17 Perlin Mark W. Method and system for DNA mixture analysis
US20050282197A1 (en) * 2001-12-21 2005-12-22 The Secretary Of State For The Home Department Interpreting DNA

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bill M et al.: "PENDULUM-a guideline-based approach to the interpretation of STR mixtures.", Forensic Science International, Vol. 148, No. 2-3, 10 March 2005, pages 181-189, XP004705621, ISSN: 0379-0738, see page 183, right-hand column, page 184, and page 186. *
Gill P et al., "Interpreting simple STR mixtures using allele peak areas.", Forensic Science International, Vol. 91, No. 1, 1998, pages 41-53, XP001012655, ISSN: 0379-0738, see pages 42 and 45. *
Perlin MW, et al.: "Linear mixture analysis: a mathematical approach to resolving mixed DNA samples.", Journal of Forensic Sciences, Vol. 46, No. 6, Nov 2001, pages 1372-1378, XP009014093, ISSN: 0022-1198, page 1372 right-hand column, page 1374, right-hand column, and page 1375, right-hand column. *

Also Published As

Publication number Publication date
GB0818032D0 (en) 2008-11-05

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Legal Events

Date Code Title Description
R108 Alteration of time limits (patents rules 1995)

Free format text: EXTENSION ALLOWED

Effective date: 20110203

Free format text: EXTENSION APPLICATION

Effective date: 20111111

WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)