GB2317562A - Lipid vehicle drug delivery composition containing vitamin E - Google Patents
Lipid vehicle drug delivery composition containing vitamin EInfo
- Publication number
- GB2317562A GB2317562A GB9800424A GB9800424A GB2317562A GB 2317562 A GB2317562 A GB 2317562A GB 9800424 A GB9800424 A GB 9800424A GB 9800424 A GB9800424 A GB 9800424A GB 2317562 A GB2317562 A GB 2317562A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lipid vehicle
- drug delivery
- delivery composition
- composition containing
- containing vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Abstract
The present invention provides a drug delivery composition comprising a lipid vehicle containing a drug and Vitamin E to enhance the solubility of the active drug in the lipid vehicle. The composition is particularly useful for drugs which are poorly soluble. The composition may be in the form of a liposome or an oil-in-water emulsion. The Vitamin E may be mixed with a pharmaceutically acceptable oil such as a marine oil or a vegetable oil.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9800424A GB2317562B (en) | 1995-07-20 | 1996-07-22 | Lipid vehicle drug delivery composition containing vitamin E |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9514878.9A GB9514878D0 (en) | 1995-07-20 | 1995-07-20 | Vitamin E as a solubilizer for drugs contained in lipid vehicles |
PCT/GB1996/001758 WO1997003651A1 (en) | 1995-07-20 | 1996-07-22 | Lipid vehicle drug delivery composition containing vitamin e |
GB9800424A GB2317562B (en) | 1995-07-20 | 1996-07-22 | Lipid vehicle drug delivery composition containing vitamin E |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9800424D0 GB9800424D0 (en) | 1998-03-04 |
GB2317562A true GB2317562A (en) | 1998-04-01 |
GB2317562B GB2317562B (en) | 1999-08-18 |
Family
ID=26307433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9800424A Expired - Fee Related GB2317562B (en) | 1995-07-20 | 1996-07-22 | Lipid vehicle drug delivery composition containing vitamin E |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2317562B (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989003689A1 (en) * | 1987-10-19 | 1989-05-05 | The Liposome Company, Inc. | Tocopherol-based pharmaceutical systems |
EP0391369B1 (en) * | 1989-04-05 | 1994-08-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
DE4322826A1 (en) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmaceutical preparation |
WO1995031217A1 (en) * | 1994-05-16 | 1995-11-23 | Dumex-Alpharma A/S | Tocopherol compositions for delivery of biologically active agents |
US5478860A (en) * | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU215966B (en) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Oral multiple emulsion-preconcentrate containing cyclosporin |
EP0825849A1 (en) * | 1995-05-19 | 1998-03-04 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
-
1996
- 1996-07-22 GB GB9800424A patent/GB2317562B/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989003689A1 (en) * | 1987-10-19 | 1989-05-05 | The Liposome Company, Inc. | Tocopherol-based pharmaceutical systems |
EP0391369B1 (en) * | 1989-04-05 | 1994-08-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
US5478860A (en) * | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
DE4322826A1 (en) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmaceutical preparation |
WO1995031217A1 (en) * | 1994-05-16 | 1995-11-23 | Dumex-Alpharma A/S | Tocopherol compositions for delivery of biologically active agents |
Also Published As
Publication number | Publication date |
---|---|
GB9800424D0 (en) | 1998-03-04 |
GB2317562B (en) | 1999-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20020722 |