GB2294808B - Method and device for biochemical sensing - Google Patents

Method and device for biochemical sensing

Info

Publication number
GB2294808B
GB2294808B GB9600475A GB9600475A GB2294808B GB 2294808 B GB2294808 B GB 2294808B GB 9600475 A GB9600475 A GB 9600475A GB 9600475 A GB9600475 A GB 9600475A GB 2294808 B GB2294808 B GB 2294808B
Authority
GB
United Kingdom
Prior art keywords
binding
target material
measurement
backgate
bias
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9600475A
Other versions
GB9600475D0 (en
GB2294808A (en
Inventor
James W Holm-Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOLM KENNEDY JAMES W
Original Assignee
HOLM KENNEDY JAMES W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOLM KENNEDY JAMES W filed Critical HOLM KENNEDY JAMES W
Priority claimed from GB9410175A external-priority patent/GB2278235B/en
Publication of GB9600475D0 publication Critical patent/GB9600475D0/en
Publication of GB2294808A publication Critical patent/GB2294808A/en
Application granted granted Critical
Publication of GB2294808B publication Critical patent/GB2294808B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

Abstract

A method and application for detecting and measuring the presence of a binding target material (64) employs a semiconductor device (50) having a receptor-covered surface topgate (90), separated by a dielectric layer (58) from a substrate 56. Receptors 66 attached to this surface exhibit a chemical selectivity function. Binding occurs in a test solution (52) with charge associated with the target material (64) modulating at least one device characteristic. According to the present invention, measurement may occur under dry conditions, at a time and location different from when binding occurred, thus substantially eliminating problems associated with ionic shielding and reference electrodes, so prevalent with prior art wet measurement techniques. The device (50) includes backgate (62) to which a bias may be applied to restore the device's pre-binding characteristics which enhances the sensitivity of the device. Measurement of the restorative backgate bias provides a signal indicating binding of the desired target material. <IMAGE>
GB9600475A 1991-10-21 1992-10-20 Method and device for biochemical sensing Expired - Fee Related GB2294808B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78147991A 1991-10-21 1991-10-21
GB9410175A GB2278235B (en) 1991-10-21 1992-10-20 Method and device for biochemical sensing

Publications (3)

Publication Number Publication Date
GB9600475D0 GB9600475D0 (en) 1996-03-13
GB2294808A GB2294808A (en) 1996-05-08
GB2294808B true GB2294808B (en) 1996-07-10

Family

ID=26304919

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9600475A Expired - Fee Related GB2294808B (en) 1991-10-21 1992-10-20 Method and device for biochemical sensing

Country Status (1)

Country Link
GB (1) GB2294808B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104781658B (en) * 2012-10-16 2017-11-21 皇家飞利浦有限公司 Integrated circuit, sensor device, measuring method and manufacture method with nano wire CHEMFET sensors
EP2746760B1 (en) * 2012-12-21 2018-02-07 Stichting IMEC Nederland 2DEG sensor, method for making such sensor and use of such sensor
JP2019501383A (en) * 2015-12-09 2019-01-17 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． Methods and systems for sensing with modified nanostructures

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180771A (en) * 1977-12-02 1979-12-25 Airco, Inc. Chemical-sensitive field-effect transistor
US4961833A (en) * 1988-03-31 1990-10-09 Kabushiki Kaisha Toshiba Field-effect transistor-type semiconductor sensor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180771A (en) * 1977-12-02 1979-12-25 Airco, Inc. Chemical-sensitive field-effect transistor
US4961833A (en) * 1988-03-31 1990-10-09 Kabushiki Kaisha Toshiba Field-effect transistor-type semiconductor sensor

Also Published As

Publication number Publication date
GB9600475D0 (en) 1996-03-13
GB2294808A (en) 1996-05-08

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20011020