GB2244130A - Transferring liquid samples - Google Patents

Transferring liquid samples Download PDF

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Publication number
GB2244130A
GB2244130A GB9109330A GB9109330A GB2244130A GB 2244130 A GB2244130 A GB 2244130A GB 9109330 A GB9109330 A GB 9109330A GB 9109330 A GB9109330 A GB 9109330A GB 2244130 A GB2244130 A GB 2244130A
Authority
GB
United Kingdom
Prior art keywords
samples
stand
row
wells
plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9109330A
Other versions
GB2244130B (en
GB9109330D0 (en
Inventor
Pekka Ronka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Oy
Original Assignee
Labsystems Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labsystems Oy filed Critical Labsystems Oy
Publication of GB9109330D0 publication Critical patent/GB9109330D0/en
Publication of GB2244130A publication Critical patent/GB2244130A/en
Application granted granted Critical
Publication of GB2244130B publication Critical patent/GB2244130B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Apparatus for transferring liquid samples from test tubes (3) to cuvette arrays (2) has a liquid dispenser with transfer tips (7), the spacing of which are a multiple of the spacing of the cuvettes. <IMAGE>

Description

Ir k -, -4. cl. -1 -- - ' ---) -.=- -.0.
1 APPARATUS FOR TRANSFERING SAMPLES The invention concerns an apparatus for transf ering liquid samples f rom a sample tube to cuvettes of a cuvette matrix, such as the microtitration plate. The invention is suitable for use especially in the field of the clinical analysing technique.
Blood samples f or clinical analyses are in general taken to test tubes the volume of which is several milliliters. E.g. antibody testings with the EIA or a corresponding method are performed generally in reaction vessels that are considerably smaller. Also, in general, several samples are tested simultaneously. Generally used for this purpose are standardized microtitration plates with 8 x 12 sample cuvettes with a spacing of 9 mm.
At present, the samples are transferred from the test tubes to the analyzing plate one sample at a time, when the diameter of the test tubes is bigger that the spacing of the sample wells on the plate. For this reason the transfering takes considerably time.
Thus, the aim of the invention is to create a system to make the transfer of samples faster in cases described above.
The aim of the invention is attained by means described in the independent claim.
One application of the invention is described in more detail in the following. Among the schematical drawings of the description, figure 1 illustrates the transfer of samples, viewed from above, figure 2 illustrates the apparatus to be used for the transfer diagonally from the front, and figure 3 illustrates the placement of the test tubes in their stand.
The samples are moved to the wells 2 of the microtitration plate 1. The plate comprises 12 rows with 8 wells each, with a spacing of 9 mm. Diameter of the wells is abt. 7 mn. The wells of the row are marked from the outermost in succession with letters A to H.
The samples have been taken to the test tubes 3, the 2 diameter of which is abt. 12 mm. The test tubes are placed in the stand 4.
The test tubes 3 are in two rows in the stand 4. Both of the rows have four tubes with a spacing of 18 mm.
Samples meant to every other well of the row of the plate 1 from the first one on (A, C, E and G) are in the first row and samples meant to the other wells of the row (B, D, F and H) are in the second row. The plate and the test tube stand are placed- on the same plane with the apparatus so that the rows of the plate and the stand are parallel and the first tube of the first row of the stand is on the same line with the outermost wells A of the rows of the plate and correspondingly the first tube of the second row is on the same line as the wells B of the plate.
Above the transfering level there is a movable liquid dispenser 5 with four applicators equipped with replace able tips in a row with a spacing of 18 mm. The row of applicators is parallel with the test tube row. In addition, the apparatus comprises an operating mechanism for the liquid dispenser.
The liquid dispenser 5 can be lowered down to suck the liquid into the tanks 6 or to remove it from the tanks.
The dispenser can be moved in cross direction to the test tube rows. in addition, the dispenser can be moved in the same direction with the row so much as to be able to take the samples from both of the test tube rows.The desired, adjustable amount of liquid can be sucked into the tips and removed to the desired place.
In addition, the transfer apparatus comprises a packing of tips 8, with tips 6 in a corresponding matrix 8 x 12.
The dispenser 5 has in addition a tip removing means by which the used tips can be removed. The means comprises a basin 9 for the used tips.
The dispenser 5 can be a device corresponding to a multi-channel line pipette (see e.g. publications FI 52025, FI 60137, FI 57704, FI 58875, FI 844906 and FI 73368). The pipette is used here mechanically and the C z i 'I 1 i k 1 3 movements can be programmed in advance to the control unit. The volume is controlled by hand. The pipette is changeable.
In addition, the apparatus comprises a reagent stand 10 corresponding by its geometry to the test tube stand 4. The dispenser takes reagent, when needed, from the reagent stand to the wells of the plate 1.
When using the apparatus, to begin with, the test tube stand 4 its test tubes 3 is put in its place. The appara tus is started, whereby the dispenser 5 first takes the tips 6 from the packing 8, then takes the samples from the first row of the stand to the wells A, C, E and G of the first row of the plate 1 and removes the tips to the basin 9. In the corresponding way the samples are transferred to the wells B, D, F and H, after which a new sample stand will be changed and the same process continued until a desired amount of samples has been transferred to the wells of the plate. Depending on the analytical procedure also reagents can be applied to the wells, if necessary.
The amount of each sample in the tubes 3 can vary. For this reason the tubes in the stand 4 can be placed on the desired height so that the surface of liquid of each tube is on the same level. This is achieved by means of flexible claws 11, that press the tubes from sides and keep the tube in its place by the help of friction.
b 4 claims 1. An apparatus for transf ering liquid samples by means of a despenser from test tubes to cuvettes placed in rows, whereby sample is taken with applicators from the test tubes and dosed to the cuvettes, characterized in that the liquid dispenser has several transfer tips in a row for simultaneously taking samples and dosing them, and that the distance between the centres of the tips is a multiple of the distance between the centres of the cuvettes.
2. An apparatus as claimed in claim 1, characterized in that the dispenser is changeable.
3. An apparatus f or transf ering samples from test tubes placed in a stand as claimed in claims 1 or 2, characterized in that the test tube stand is equipped with an apparatus to place the test tubes so that their liquid surf aces are at the same level.
4. An apparatus according to claim 1, substantially as hereinbefore described with reference to and as shown in Figures 1, 2 and 3 of the accompanying drawings.
Published 1991 at 7he Patent Office. Concept House. Cardiff Road. Newport. Gwent NP9 1RH. Further copies may be obtained from Sales Branch. Unit 6. Nine Mile Point. Cwrafelinfach, Cross Keys, Newport. NP1 7HZ. Printed by Multiplex techniques ltd, St Mary Cray. Kent.
Q
GB9109330A 1990-05-02 1991-04-30 Apparatus for transfering samples Expired - Fee Related GB2244130B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI902189A FI87738C (en) 1990-05-02 1990-05-02 Device for moving samples

Publications (3)

Publication Number Publication Date
GB9109330D0 GB9109330D0 (en) 1991-06-19
GB2244130A true GB2244130A (en) 1991-11-20
GB2244130B GB2244130B (en) 1994-04-27

Family

ID=8530354

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9109330A Expired - Fee Related GB2244130B (en) 1990-05-02 1991-04-30 Apparatus for transfering samples

Country Status (6)

Country Link
JP (1) JPH04230862A (en)
DE (1) DE4113541A1 (en)
FI (1) FI87738C (en)
FR (1) FR2661751B1 (en)
GB (1) GB2244130B (en)
IT (1) IT1249300B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323567B2 (en) 2005-10-04 2012-12-04 Canon Kabushiki Kaisha Biochemical treatment device with dispensing unit
ITRE20130097A1 (en) * 2013-12-27 2015-06-28 Spire S R L MACHINE AND A METHOD OF INSEMINATION OF DIAGNOSTIC PLATES

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10006846C2 (en) * 2000-02-16 2002-03-07 Macherey Nagel Gmbh & Co Hg Process for photometric COD measurement
US7125722B2 (en) 2002-07-03 2006-10-24 Abbott Laboratories Apparatus and method for handling fluids for analysis
CN114832875A (en) * 2022-05-28 2022-08-02 深圳市宝鼎丰科技有限公司 Integrated micro-fluidic chip equipment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1014462A (en) * 1963-08-24 1965-12-22 Peter James Littlejohns Sequei Multiple pipetting apparatus
US4342407A (en) * 1975-07-11 1982-08-03 Dynatech Laboratories, Incorporated Liquid dispensing apparatus
DE2607055A1 (en) * 1976-02-20 1977-09-01 Bodenuntersuchungs Inst Koldin Fluid sample analyser for soil extracts - has three conveyors carrying soil vessels to flame and spectral photometers and pH meter
DE3346532A1 (en) * 1982-12-22 1984-07-12 Olympus Optical Co., Ltd., Tokio/Tokyo Method of controlling an analyser for chemical analyses
CH671526A5 (en) * 1985-12-17 1989-09-15 Hamilton Bonaduz Ag
GB8809611D0 (en) * 1988-04-22 1988-05-25 Darougar S Deposition apparatus
DE3836163A1 (en) * 1988-10-24 1990-04-26 Berthold Lab Prof R RECORDING SYSTEM FOR SEVERAL SAMPLE VESSELS FOR CARRYING OUT RADIATION MEASUREMENTS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323567B2 (en) 2005-10-04 2012-12-04 Canon Kabushiki Kaisha Biochemical treatment device with dispensing unit
ITRE20130097A1 (en) * 2013-12-27 2015-06-28 Spire S R L MACHINE AND A METHOD OF INSEMINATION OF DIAGNOSTIC PLATES

Also Published As

Publication number Publication date
FI902189A (en) 1991-11-03
DE4113541A1 (en) 1991-11-07
ITMI911189A1 (en) 1992-11-02
FI902189A0 (en) 1990-05-02
ITMI911189A0 (en) 1991-05-02
IT1249300B (en) 1995-02-22
FR2661751B1 (en) 1993-04-09
GB2244130B (en) 1994-04-27
JPH04230862A (en) 1992-08-19
GB9109330D0 (en) 1991-06-19
FI87738C (en) 1993-10-13
FI87738B (en) 1992-11-13
FR2661751A1 (en) 1991-11-08

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PCNP Patent ceased through non-payment of renewal fee